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    Cyrib CYFIP related Rac1 interactor B [ Mus musculus (house mouse) ]

    Gene ID: 223601, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Cyribprovided by MGI
    Official Full Name
    CYFIP related Rac1 interactor Bprovided by MGI
    Primary source
    MGI:MGI:1923520
    See related
    Ensembl:ENSMUSG00000022378 AllianceGenome:MGI:1923520
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam49b; 0910001A06Rik
    Summary
    Enables MHC class Ib protein binding, via antigen binding activity groove. Involved in several processes, including positive regulation of T cell mediated cytotoxicity; positive regulation of interferon-gamma production; and positive regulation of memory T cell activation. Located in cilium. Orthologous to human CYRIB (CYFIP related Rac1 interactor B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 24.7), cerebellum adult (RPKM 18.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 D1; 15 28.16 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63800943..63932627, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63929094..64060778, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene gasdermin C4 Neighboring gene gasdermin C-like, pseudogene Neighboring gene STARR-seq mESC enhancer starr_38847 Neighboring gene STARR-seq mESC enhancer starr_38849 Neighboring gene predicted gene, 25628 Neighboring gene STARR-positive B cell enhancer ABC_E10857 Neighboring gene STARR-positive B cell enhancer ABC_E9912 Neighboring gene STARR-positive B cell enhancer ABC_E1906 Neighboring gene predicted gene 20717 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain1 Neighboring gene STARR-seq mESC enhancer starr_38853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:64017486-64017639 Neighboring gene STARR-seq mESC enhancer starr_38854 Neighboring gene VISTA enhancer mm1716 Neighboring gene STARR-seq mESC enhancer starr_38855 Neighboring gene RIKEN cDNA 1700010G06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner. Huang Z, et al. Mol Immunol, 2022 Mar. PMID 35131594
    2. FAM49B, a novel regulator of mitochondrial function and integrity that suppresses tumor metastasis. Chattaragada MS, et al. Oncogene, 2018 Feb 8. PMID 29059164, Free PMC Article
    3. CYRI/FAM49B negatively regulates RAC1-driven cytoskeletal remodelling and protects against bacterial infection. Yuki KE, et al. Nat Microbiol, 2019 Sep. PMID 31285585
    4. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nagarajan NA, et al. Nat Immunol, 2012 Apr 22. PMID 22522492, Free PMC Article
    5. Proteomic analysis of mammalian primary cilia. Ishikawa H, et al. Curr Biol, 2012 Mar 6. PMID 22326026, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
      Title: Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
    2. FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
      Title: FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class Ib protein binding, via antigen binding groove IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to molecule of bacterial origin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to molecule of bacterial origin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of small GTPase mediated signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of T cell mediated cytotoxicity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of memory T cell activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of type II interferon production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CYFIP-related Rac1 interactor B
    Names
    family with sequence similarity 49, member B
    protein FAM49B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360035.1 → NP_001346964.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1. 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC140673, AC156573
      Consensus CDS
      CCDS27505.1
      UniProtKB/Swiss-Prot
      Q921M7
      Related
      ENSMUSP00000132486.2, ENSMUST00000164532.3
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    2. NM_001360036.1 → NP_001346965.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC140673, AC156573
      Consensus CDS
      CCDS27505.1
      UniProtKB/Swiss-Prot
      Q921M7
      Related
      ENSMUSP00000154320.2, ENSMUST00000228226.2
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    3. NM_001360037.1 → NP_001346966.1  CYFIP-related Rac1 interactor B isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.z
      Source sequence(s)
      AC140673, AC156573
      Consensus CDS
      CCDS27505.1
      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    4. NM_001360038.1 → NP_001346967.1  CYFIP-related Rac1 interactor B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a alternate AUG and result in an isoform (2) with a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC140673, AC156573
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    5. NM_144846.5 → NP_659095.1  CYFIP-related Rac1 interactor B isoform 1

      See identical proteins and their annotated locations for NP_659095.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1. 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK028062, BX527479, CK633763
      Consensus CDS
      CCDS27505.1
      UniProtKB/Swiss-Prot
      Q921M7
      Related
      ENSMUSP00000066359.5, ENSMUST00000063838.11
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      63800943..63932627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248469.1 → XP_030104329.1  CYFIP-related Rac1 interactor B isoform X2

      Conserved Domains (2) summary
      PRK12323
      Location:1 → 91
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07159
      Location:109 → 404
      DUF1394; Protein of unknown function (DUF1394)

    2. XM_030248468.1 → XP_030104328.1  CYFIP-related Rac1 interactor B isoform X1

      Conserved Domains (2) summary
      PRK12323
      Location:1 → 129
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07159
      Location:121 → 417
      DUF1394; Protein of unknown function (DUF1394)

    3. XM_030248475.1 → XP_030104335.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    4. XM_030248470.2 → XP_030104330.1  CYFIP-related Rac1 interactor B isoform X3

      Conserved Domains (2) summary
      PRK12323
      Location:1 → 108
      PRK12323; DNA polymerase III subunit gamma/tau
      pfam07159
      Location:104 → 400
      DUF1394; Protein of unknown function (DUF1394)

    5. XM_030248471.2 → XP_030104331.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    6. XM_030248472.1 → XP_030104332.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    7. XM_036159327.1 → XP_036015220.1  CYFIP-related Rac1 interactor B isoform X5

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    8. XM_036159326.1 → XP_036015219.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    9. XM_030248477.2 → XP_030104337.1  CYFIP-related Rac1 interactor B isoform X5

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    10. XM_030248474.2 → XP_030104334.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    11. XM_030248476.2 → XP_030104336.1  CYFIP-related Rac1 interactor B isoform X5

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    12. XM_011245564.3 → XP_011243866.1  CYFIP-related Rac1 interactor B isoform X5

      See identical proteins and their annotated locations for XP_011243866.1

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    13. XM_006520763.4 → XP_006520826.1  CYFIP-related Rac1 interactor B isoform X4

      See identical proteins and their annotated locations for XP_006520826.1

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    14. XM_030248478.1 → XP_030104338.1  CYFIP-related Rac1 interactor B isoform X6

      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    15. XM_006520764.5 → XP_006520827.1  CYFIP-related Rac1 interactor B isoform X4

      See identical proteins and their annotated locations for XP_006520827.1

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    16. XM_006520766.3 → XP_006520829.1  CYFIP-related Rac1 interactor B isoform X6

      See identical proteins and their annotated locations for XP_006520829.1

      Conserved Domains (1) summary
      pfam07159
      Location:1 → 174
      DUF1394; Protein of unknown function (DUF1394)

    17. XM_006520762.5 → XP_006520825.1  CYFIP-related Rac1 interactor B isoform X5

      See identical proteins and their annotated locations for XP_006520825.1

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    18. XM_030248473.2 → XP_030104333.1  CYFIP-related Rac1 interactor B isoform X4

      UniProtKB/Swiss-Prot
      Q921M7
      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)

    19. XM_006520765.3 → XP_006520828.1  CYFIP-related Rac1 interactor B isoform X5

      See identical proteins and their annotated locations for XP_006520828.1

      Conserved Domains (1) summary
      pfam07159
      Location:18 → 320
      DUF1394; Protein of unknown function (DUF1394)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921M7.1 GenPept UniProtKB/Swiss-Prot:Q921M7

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