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    Nrsn1 neurensin 1 [ Mus musculus (house mouse) ]

    Gene ID: 22360, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nrsn1provided by MGI
    Official Full Name
    neurensin 1provided by MGI
    Primary source
    MGI:MGI:894662
    See related
    Ensembl:ENSMUSG00000048978 AllianceGenome:MGI:894662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vmp; Neuro-p24; Neurensin-1
    Summary
    Acts upstream of or within nervous system development. Located in cytoplasmic vesicle; growth cone; and neuronal cell body. Is expressed in several structures, including adrenal gland; eye; gonad; gut; and nervous system. Orthologous to human NRSN1 (neurensin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 110.6), frontal lobe adult (RPKM 100.2) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 A3.1; 13 11.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25436022..25453979, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (25252039..25269996, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene doublecortin domain containing 2a Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene STARR-seq mESC enhancer starr_33994 Neighboring gene predicted gene, 34122 Neighboring gene triosephosphate isomerase related sequence 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulatory expression of Neurensin-1 in the spinal motor neurons after mouse sciatic nerve injury. Suzuki H, et al. Neurosci Lett, 2007 Jun 27. PMID 17566649
    2. Neurensin-1 expression in the mouse retina during postnatal development and in the cultured retinal neurons. Nagata K, et al. Brain Res, 2006 Apr 7. PMID 16696124
    3. Multiple repressive mechanisms in the hippocampus during memory formation. Cho J, et al. Science, 2015 Oct 2. PMID 26430118
    4. Developmentally regulated expression of Neuro-p24 and its possible function in neurite extension. Araki M, et al. Neurosci Res, 2002 Dec. PMID 12445626
    5. A newly identified membrane protein localized exclusively in intracellular organelles of neurons. Kadota Y, et al. Brain Res Mol Brain Res, 1997 Jun. PMID 9191101

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In behavioral analyses, overexpressing Nrsn1, one of the newly identified genes undergoing rapid translational repression, or activating ESR1 in the hippocampus impaired memory formation.
      Title: Multiple repressive mechanisms in the hippocampus during memory formation.
    2. The results of this study indicate that Nrsn1 plays an active role in axonal regeneration as well as in embryonic development.
      Title: Regulatory expression of Neurensin-1 in the spinal motor neurons after mouse sciatic nerve injury.
    3. Neurensin-2 was expressed in small vesicles including lysosomes in the perinuclear region. And was found in cell bodies.
      Title: Molecular characterization of a transport vesicle protein Neurensin-2, a homologue of Neurensin-1, expressed in neural cells.
    4. Neurensin-1 plays a role in the fiber extension of the retinal neurons, and indicate that the developing retina is a suitable experimental model for the analysis of Neurensin function, both in vivo and in vitro.
      Title: Neurensin-1 expression in the mouse retina during postnatal development and in the cultured retinal neurons.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurensin-1
    Names
    vesicular membrane protein of 24 kDa
    vesicular membrane protein p24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426601.1 → NP_001413530.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799

    2. NM_001426602.1 → NP_001413531.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799

    3. NM_001426603.1 → NP_001413532.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799

    4. NM_001426604.1 → NP_001413533.1  neurensin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589766
      UniProtKB/Swiss-Prot
      P97799

    5. NM_001426605.1 → NP_001413534.1  neurensin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589766

    6. NM_009513.2 → NP_033539.1  neurensin-1 isoform 1

      See identical proteins and their annotated locations for NP_033539.1

      Status: VALIDATED

      Source sequence(s)
      AU080650, BC052019
      Consensus CDS
      CCDS26387.1
      UniProtKB/Swiss-Prot
      P97799
      Related
      ENSMUSP00000055048.7, ENSMUST00000057866.13
      Conserved Domains (1) summary
      pfam14927
      Location:24 → 154
      Neurensin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      25436022..25453979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315503.2 → XP_017170992.1  neurensin-1 isoform X1

      UniProtKB/Swiss-Prot
      P97799
      Conserved Domains (1) summary
      pfam14927
      Location:24 → 154
      Neurensin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97799.1 GenPept UniProtKB/Swiss-Prot:P97799

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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