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    Vip vasoactive intestinal polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 22353, updated on 23-Apr-2024

    Summary

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    Official Symbol
    Vipprovided by MGI
    Official Full Name
    vasoactive intestinal polypeptideprovided by MGI
    Primary source
    MGI:MGI:98933
    See related
    Ensembl:ENSMUSG00000019772 AllianceGenome:MGI:98933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a neuropeptide of the glucagon/secretin superfamily with potent bronchodilator, immunomodulator and anti-inflammatory properties. The encoded protein is proteolytically processed to generate two structurally similar neuropeptides - vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI). In the digestive tract, VIP stimulates relaxation of enteric smooth muscle, secretion of water and electrolytes, release of insulin and glucagon, and inhibition of gastric acid secretion. In the cardiovascular system, VIP causes coronary vasodilation and stimulates contractility in the heart. Mice lacking VIP exhibit airway hyperresponsiveness and airway inflammation. Male mice lacking VIP exhibit moderate pulmonary arterial hypertension resulting in increased mortality. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in cortex adult (RPKM 14.9), large intestine adult (RPKM 14.5) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 A1; 10 1.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5589131..5597617)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5639193..5647617)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing, nuclear envelope 1 Neighboring gene STARR-seq mESC enhancer starr_25602 Neighboring gene predicted gene, 51758 Neighboring gene STARR-seq mESC enhancer starr_25600 Neighboring gene STARR-positive B cell enhancer mm9_chr10:4746082-4746383 Neighboring gene myc target 1 Neighboring gene STARR-seq mESC enhancer starr_25599 Neighboring gene predicted gene, 40595 Neighboring gene predicted gene, 47679

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway. Zhai Q, et al. iScience, 2022 May 20. PMID 35521538, Free PMC Article
    2. A subpopulation of cortical VIP-expressing interneurons with highly dynamic spines. Georgiou C, et al. Commun Biol, 2022 Apr 13. PMID 35418660, Free PMC Article
    3. Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy. Motaharinia M, et al. Nat Commun, 2021 Oct 20. PMID 34671051, Free PMC Article
    4. microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction. Qiu F, et al. Cereb Cortex, 2020 Apr 14. PMID 33676371
    5. The regulatory role of vasoactive intestinal peptide in lacrimal gland ductal fluid secretion: A new piece of the puzzle in tear production. Berczeli O, et al. Mol Vis, 2020. PMID 33311973, Free PMC Article

    See all (410) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome.
      Title: VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome.
    2. VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals.
      Title: VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals.
    3. Donor plasmacytoid dendritic cells limit graft-versus-host disease through vasoactive intestinal polypeptide expression.
      Title: Donor plasmacytoid dendritic cells limit graft-versus-host disease through vasoactive intestinal polypeptide expression.
    4. microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.
      Title: microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction.
    5. Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus.
      Title: Different Roles for VIP Neurons in the Neonatal and Adult Suprachiasmatic Nucleus.
    6. The regulatory role of vasoactive intestinal peptide in lacrimal gland ductal fluid secretion: A new piece of the puzzle in tear production.
      Title: The regulatory role of vasoactive intestinal peptide in lacrimal gland ductal fluid secretion: A new piece of the puzzle in tear production.
    7. Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).
      Title: Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).
    8. Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas.
      Title: Role of VIP and Sonic Hedgehog Signaling Pathways in Mediating Epithelial Wound Healing, Sensory Nerve Regeneration, and Their Defects in Diabetic Corneas.
    9. The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit.
      Title: The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit.
    10. In the brain, VIP plays an important role in CNS development. Its effects are excitatory, inhibitory, biphasic or none, depending on the particular neuron. VIP enhances inhibition imposed on GABAergic interneurons by utilizing pre and postsynaptic receptors. Review.
      Title: Updating the picture of layer 2/3 VIP-expressing interneuron function in the mouse cerebral cortex.
    Submit: New GeneRIF Correction See all GeneRIFs (107)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107202

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hormone activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antifungal humoral response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epinephrine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in learning or memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to yeast ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    VIP peptides
    Names
    PHI, peptide histidine isoleucine

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313969.1 → NP_001300898.1  VIP peptides isoform 2 preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AK018599, BE990430
      UniProtKB/Swiss-Prot
      P32648
      Conserved Domains (1) summary
      pfam00123
      Location:82 → 108
      Hormone_2; Peptide hormone

    2. NM_001407530.1 → NP_001394459.1  VIP peptides isoform 3 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC157020, AC162387
      UniProtKB/Swiss-Prot
      P32648, Q9D2Z7, Q9QUN1

    3. NM_001407531.1 → NP_001394460.1  VIP peptides isoform 4 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC157020, AC162387

    4. NM_001407532.1 → NP_001394461.1  VIP peptides isoform 5 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC157020, AC162387

    5. NM_001407533.1 → NP_001394462.1  VIP peptides isoform 6 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC157020, AC162387

    6. NM_001407534.1 → NP_001394463.1  VIP peptides isoform 7 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC157020, AC162387

    7. NM_011702.3 → NP_035832.1  VIP peptides isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_035832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK018599, BE990430
      Consensus CDS
      CCDS56682.1
      UniProtKB/TrEMBL
      A0A0R4J003
      Related
      ENSMUSP00000019906.5, ENSMUST00000019906.6
      Conserved Domains (1) summary
      pfam00123
      Location:82 → 108
      Hormone_2; Peptide hormone

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      5589131..5597617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512446.2 → XP_006512509.1  VIP peptides isoform X1

      Conserved Domains (1) summary
      pfam00123
      Location:82 → 109
      Hormone_2; Peptide hormone
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32648.1 GenPept UniProtKB/Swiss-Prot:P32648

    Gene LinkOut

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    Chemical Information
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