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    Marchf6 membrane associated ring-CH-type finger 6 [ Mus musculus (house mouse) ]

    Gene ID: 223455, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Marchf6provided by MGI
    Official Full Name
    membrane associated ring-CH-type finger 6provided by MGI
    Primary source
    MGI:MGI:2442773
    See related
    Ensembl:ENSMUSG00000039100 AllianceGenome:MGI:2442773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    March6; mKIAA0597; 3830408G03; F830029L24Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity; ubiquitin protein ligase activity; and ubiquitin-specific protease binding activity. Predicted to be involved in protein K48-linked ubiquitination and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 3. Orthologous to human MARCHF6 (membrane associated ring-CH-type finger 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.9), whole brain E14.5 (RPKM 26.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B2; 15 12.95 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (31456045..31531172, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (31455899..31531082, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38287 Neighboring gene predicted gene, 41286 Neighboring gene STARR-seq mESC enhancer starr_38289 Neighboring gene STARR-positive B cell enhancer ABC_E10847 Neighboring gene ropporin 1-like Neighboring gene ubiquitin-conjugating enzyme E2 variant 2 pseudogene Neighboring gene predicted gene, 49208 Neighboring gene STARR-seq mESC enhancer starr_38292 Neighboring gene carboxymethylenebutenolidase homolog Neighboring gene STARR-positive B cell enhancer ABC_E4130 Neighboring gene chaperonin containing TCP1 subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis. Nguyen KT, et al. Nat Cell Biol, 2022 Aug. PMID 35941365
    2. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
      Title: Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons.
    2. The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.
      Title: The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-specific protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF6
    Names
    E3 ubiquitin-protein ligase MARCH6
    MARCH-VI
    RING-type E3 ubiquitin transferase MARCH6
    RING-type E3 ubiquitin transferase MARCHF6
    membrane-associated RING finger protein 6
    membrane-associated RING-CH protein VI
    membrane-associated ring finger (C3HC4) 6
    NP_001389808.1
    NP_766194.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402879.1 → NP_001389808.1  E3 ubiquitin-protein ligase MARCHF6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115735

    2. NM_172606.3 → NP_766194.2  E3 ubiquitin-protein ligase MARCHF6 isoform 1

      See identical proteins and their annotated locations for NP_766194.2

      Status: VALIDATED

      Source sequence(s)
      AC115735
      Consensus CDS
      CCDS37054.1
      UniProtKB/Swiss-Prot
      Q6PCS1, Q6ZQ89, Q80V02, Q80VC7, Q8BJA0, Q8BXX6
      Related
      ENSMUSP00000087694.5, ENSMUST00000090227.6
      Conserved Domains (1) summary
      smart00744
      Location:8 → 56
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      31456045..31531172 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQ89.2 GenPept UniProtKB/Swiss-Prot:Q6ZQ89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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