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    Stk24 serine/threonine kinase 24 [ Mus musculus (house mouse) ]

    Gene ID: 223255, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Stk24provided by MGI
    Official Full Name
    serine/threonine kinase 24provided by MGI
    Primary source
    MGI:MGI:2385007
    See related
    Ensembl:ENSMUSG00000063410 AllianceGenome:MGI:2385007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mst3; MST-3; STE20; 1810013H02Rik
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of axon regeneration; and response to hydrogen peroxide. Predicted to act upstream of or within apoptotic process and phosphorylation. Predicted to be located in Golgi membrane; cytosol; and nucleolus. Is expressed in brain. Orthologous to human STK24 (serine/threonine kinase 24). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 21.9), large intestine adult (RPKM 15.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 E5; 14 64.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (121521599..121618269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121284187..121380496, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37701 Neighboring gene STARR-seq mESC enhancer starr_37702 Neighboring gene importin 5 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1 Neighboring gene RIKEN cDNA B930095G15 gene Neighboring gene STARR-seq mESC enhancer starr_37715 Neighboring gene STARR-seq mESC enhancer starr_37718 Neighboring gene STARR-positive B cell enhancer ABC_E1475 Neighboring gene STARR-positive B cell enhancer ABC_E478 Neighboring gene STARR-seq mESC enhancer starr_37728 Neighboring gene STARR-seq mESC enhancer starr_37729 Neighboring gene STARR-positive B cell enhancer ABC_E11584 Neighboring gene predicted gene, 33299 Neighboring gene STARR-seq mESC enhancer starr_37731 Neighboring gene solute carrier family 15 (oligopeptide transporter), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3. Liu Y, et al. J Biol Chem, 2022 May. PMID 35413286, Free PMC Article
    2. Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome. Qin Q, et al. Cell Rep, 2021 May 25. PMID 34038725
    3. MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake. Chan CH, et al. Int J Mol Sci, 2021 Jan 20. PMID 33498219, Free PMC Article
    4. MST3 is involved in ENaC-mediated hypertension. Lu TJ, et al. Am J Physiol Renal Physiol, 2019 Jul 1. PMID 30969802
    5. The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet. Iglesias C, et al. Diabetologia, 2017 Dec. PMID 28956081

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
      Title: Protein Kinase STK24 Promotes Tumor Immune Evasion via the AKT-PD-L1 Axis.
    2. Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
      Title: Epithelial polarization in the 3D matrix requires MST3 signaling to regulate ZO-1 position.
    3. Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
      Title: Sterile 20-like kinase 3 promotes tick-borne encephalitis virus assembly by interacting with NS2A and prM and enhancing the NS2A-NS4A association.
    4. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
      Title: Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation.
    5. Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
      Title: Biochemical purification uncovers mammalian sterile 3 (MST3) as a new protein kinase for multifunctional protein kinases AMPK and SIK3.
    6. GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
      Title: GCKIII (Germinal Center Kinase III) Kinases STK24 and STK25 (Serine/Threonine Kinase 24 and 25) Inhibit Cavernoma Development.
    7. STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
      Title: STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons.
    8. MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
      Title: MST3 Involvement in Na(+) and K(+) Homeostasis with Increasing Dietary Potassium Intake.
    9. MST3 protein coats lipid droplets in mouse liver cells from mice fed a high-fat diet. MST3 fully colocalized with ADRP, the main LD-coating protein in mouse liver. No MST3 protein was detected in the cytosolic fraction. High mRNA and protein expression of MST3 was also found in organs that do not accumulate significant amounts of intracellular LDs.
      Title: Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans.
    10. results indicated that serine/threonine kinase 24 (MST3) maintained Na(+) homeostasis through epithelial Na(+) channel( ENaC) regulation
      Title: MST3 is involved in ENaC-mediated hypertension.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC6330

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of axon regeneration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 24
    Names
    STE20-like kinase MST3
    mammalian STE20-like protein kinase 3
    mammalian sterile twenty 3 kinase
    serine/threonine kinase 24 (STE20 homolog, yeast)
    NP_663440.1
    XP_006518981.1
    XP_011243345.1
    XP_017171477.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145465.2 → NP_663440.1  serine/threonine-protein kinase 24

      See identical proteins and their annotated locations for NP_663440.1

      Status: VALIDATED

      Source sequence(s)
      AK154959, BE687884, BY730101
      Consensus CDS
      CCDS37016.1
      UniProtKB/Swiss-Prot
      Q99KH8
      UniProtKB/TrEMBL
      Q3U335, Q3U3T6
      Related
      ENSMUSP00000078746.8, ENSMUST00000079817.8
      Conserved Domains (2) summary
      smart00220
      Location:24 → 274
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06609
      Location:22 → 295
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      121521599..121618269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518918.3 → XP_006518981.1  serine/threonine-protein kinase 24 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:1 → 197
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011245043.4 → XP_011243345.1  serine/threonine-protein kinase 24 isoform X2

      UniProtKB/TrEMBL
      Q3U3T6
      Conserved Domains (1) summary
      cd06609
      Location:21 → 294
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases

    3. XM_017315988.2 → XP_017171477.1  serine/threonine-protein kinase 24 isoform X1

      UniProtKB/TrEMBL
      Q3U3T6
      Conserved Domains (1) summary
      cd06609
      Location:34 → 307
      STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99KH8.1 GenPept UniProtKB/Swiss-Prot:Q99KH8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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