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    Vars1 valyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22321, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Vars1provided by MGI
    Official Full Name
    valyl-tRNA synthetase 1provided by MGI
    Primary source
    MGI:MGI:90675
    See related
    Ensembl:ENSMUSG00000007029 AllianceGenome:MGI:90675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G7a; Bat6; Vars; Vars2; D17H6S56E
    Summary
    Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; cranium; genitourinary system; midbrain; and telencephalon. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 96.4), spleen adult (RPKM 86.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 18.54 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35219895..35235304)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35000907..35016329)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene STARR-positive B cell enhancer ABC_E1941 Neighboring gene STARR-positive B cell enhancer ABC_E7526 Neighboring gene von Willebrand factor A domain containing 7 Neighboring gene suppressor APC domain containing 1 Neighboring gene predicted gene, 52318 Neighboring gene mutS homolog 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse p52 subunit of the transcription/DNA repair factor TFIIH is located in the class III region of the H2 complex: cloning and sequence polymorphism. Lanning D, et al. Immunogenetics, 1999 Jun. PMID 10380693
    2. The sequence and organization of the mouse valyl-tRNA synthetase gene G7a/Bat6 located in the MHC class III region. Snoek M, et al. Immunogenetics, 1999 May. PMID 10199925
    3. A gene belonging to the Sm family of snRNP core proteins maps within the mouse MHC. Bedian V, et al. Immunogenetics, 1997. PMID 9271633
    4. A novel gene, G7e, resembling a viral envelope gene, is located at the recombinational hot spot in the class III region of the mouse MHC. Snoek M, et al. Genomics, 1996 Nov 15. PMID 8954773
    5. Localization of a new gene adjacent to the HSP70 genes in human and mouse MHCs. Olavesen MG, et al. Immunogenetics, 1993. PMID 8428774

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    valine--tRNA ligase
    Names
    protein G7a
    valRS
    NP_001411919.1
    NP_035820.3
    XP_017172885.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424990.1 → NP_001411919.1  valine--tRNA ligase

      Status: VALIDATED

      Source sequence(s)
      AC087117
      UniProtKB/Swiss-Prot
      Q9QUN2, Q9Z1Q9
      UniProtKB/TrEMBL
      Q790I0

    2. NM_011690.4 → NP_035820.3  valine--tRNA ligase

      See identical proteins and their annotated locations for NP_035820.3

      Status: VALIDATED

      Source sequence(s)
      AC087117
      Consensus CDS
      CCDS37593.1
      UniProtKB/Swiss-Prot
      Q9QUN2, Q9Z1Q9
      UniProtKB/TrEMBL
      Q3U3D3, Q790I0, Q7TPT7
      Related
      ENSMUSP00000084572.8, ENSMUST00000087315.14
      Conserved Domains (2) summary
      PTZ00419
      Location:281 → 1263
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      cl02776
      Location:92 → 213
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35219895..35235304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317396.2 → XP_017172885.1  valine--tRNA ligase isoform X2

      UniProtKB/TrEMBL
      Q3TII4
      Conserved Domains (1) summary
      PTZ00419
      Location:1 → 895
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Z1Q9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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