Scgb1a1 secretoglobin, family 1A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Scgb1a1provided by MGI
Official Full Name: secretoglobin, family 1A, member 1provided by MGI
Primary source: MGI:MGI:98919
See related: Ensembl:ENSMUSG00000024653 AllianceGenome:MGI:98919
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UG; UGB; Utg; CC10; CC16; CCSP; PCB-BP
Summary: Predicted to enable polychlorinated biphenyl binding activity. Acts upstream of or within several processes, including negative regulation of T cell proliferation; negative regulation of cytokine production; and regulation of RNA metabolic process. Located in cytoplasm. Is expressed in heart and respiratory system. Used to study IgA glomerulonephritis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; and glomerulonephritis. Orthologous to human SCGB1A1 (secretoglobin family 1A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward lung adult (RPKM 38510.4) See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (9061006..9065320, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (9083642..9087956, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CC16 drives VLA-2-dependent SPLUNC1 expression.
Title: CC16 drives VLA-2-dependent SPLUNC1 expression.
The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Mycoplasma pneumoniae Infection in Mouse Tracheal Epithelial Cells.
Title: The Impact of CC16 on Pulmonary Epithelial-Driven Host Responses during Mycoplasma pneumoniae Infection in Mouse Tracheal Epithelial Cells.
CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice.
Title: CC16 augmentation reduces exaggerated COPD-like disease in Cc16-deficient mice.
Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis.
Title: Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis.
Club Cell Protein 16 Attenuates CD16(bright)CD62(dim) Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury.
Title: Club Cell Protein 16 Attenuates CD16(bright)CD62(dim) Immunosuppressive Neutrophils in Damaged Tissue upon Posttraumatic Sepsis-Induced Lung Injury.
Early local neutralization of CC16 in sepsisinduced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival.
Title: Early local neutralization of CC16 in sepsis‑induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival.
Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation and Immunity.
Title: Lung Secretoglobin Scgb1a1 Influences Alveolar Macrophage-Mediated Inflammation and Immunity.
Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR.
Title: Club cell 10-kDa protein (CC10) inhibits cPLA2/COX2 pathway to alleviate RSV-induced airway inflammation and AHR.
Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia
Title: Spatiotemporal Expression of Three Secretoglobin Proteins, SCGB1A1, SCGB3A1, and SCGB3A2, in Mouse Airway Epithelia.
low levels of epithelial SCGB1A1 in asthma are caused by reduced FOXA2 expression.
Title: The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548177

Scgb1a1 (e-PCR), detects polymorphism
- UniSTS:499112

RH134311 (e-PCR)
- UniSTS:217593

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phospholipase A2 inhibitor activity	IEA Inferred from Electronic Annotation more info
enables polychlorinated biphenyl binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-13 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-13 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-4 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-4 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-5 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-5 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of mRNA stability	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of type II interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uteroglobin

Names: Blastokinin; CCPBP; PCB-binding protein; club cell 17 kDa protein; club cell phospholipid-binding protein; club cell secretory protein; club cells 10 kDa secretory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.