Utf1 undifferentiated embryonic cell transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Utf1provided by MGI
Official Full Name: undifferentiated embryonic cell transcription factor 1provided by MGI
Primary source: MGI:MGI:1276125
See related: Ensembl:ENSMUSG00000047751 AllianceGenome:MGI:1276125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables HMG box domain binding activity; TBP-class protein binding activity; and transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; gonad; and limb mesenchyme. Orthologous to human UTF1 (undifferentiated embryonic cell transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 7.2), thymus adult (RPKM 4.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 84.91 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (139523769..139525025)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (139943856..139945112)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
Title: An Insight into the Role of UTF1 in Development, Stem Cells, and Cancer.
proper development of Utf1 null embryos almost entirely depends on the presence of functional Utf1 alleles in the parental germline. This indicates that Utf1's proposed epigenetic role in ESC pluripotency in vitro may be linked to intergenerational epigenetic inheritance in vivo.
Title: Utf1 contributes to intergenerational epigenetic inheritance of pluripotency.
UTF1 is required for embryonic development and regulates male germ cell development
Title: Embryonic lethality and defective male germ cell development in mice lacking UTF1.
LncRNA Gm2044 was identified to inhibit Utf1 mRNA translation and play important roles in spermatogenesis.
Title: LncRNA Gm2044 highly expresses in spermatocyte and inhibits Utf1 translation by interacting with Utf1 mRNA.
IPS cells derived from UTF1-selection give rise to functional CMs in vitro.
Title: Functional expression and regulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in mouse iPS cell-derived cardiomyocytes after UTF1 -neo selection.
A large region of Utf1 was found to be necessary for direct interaction with N-Myc.
Title: Myc binds the pluripotency factor Utf1 through the basic-helix-loop-helix leucine zipper domain.
Suppression of UTF1 expression in P19 cells by RNA interference enhanced retinoic acid (RA)-induced neuronal differentiation.
Title: UTF1 deficiency promotes retinoic acid-induced neuronal differentiation in P19 embryonal carcinoma cells.
Data show that UTF1 is a key chromatin component in ES cells, preventing ES cell chromatin decondensation, and aberrant gene expression; both essential for proper initiation of lineage-specific differentiation of ES cells.
Title: Undifferentiated embryonic cell transcription factor 1 regulates ESC chromatin organization and gene expression.
UTF1 is a strongly chromatin-associated protein involved in the initiation of ES cell differentiation.
Title: UTF1 is a chromatin-associated protein involved in ES cell differentiation.
These results suggest a molecular pathway by which Oct-3/4 induces rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene.
Title: Oct-3/4 maintains the proliferative embryonic stem cell state via specific binding to a variant octamer sequence in the regulatory region of the UTF1 locus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D31647 (e-PCR)
- UniSTS:163430

AI505934 (e-PCR)
- UniSTS:179668

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables HMG box domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: undifferentiated embryonic cell transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009482.2 → NP_033508.1 undifferentiated embryonic cell transcription factor 1

See identical proteins and their annotated locations for NP_033508.1

Status: PROVISIONAL

Source sequence(s)

AC107822

Consensus CDS

CCDS21958.1

UniProtKB/Swiss-Prot

O70530, Q6J1H4

UniProtKB/TrEMBL

B2RSF1

Related

ENSMUSP00000128848.3, ENSMUST00000168457.3

Conserved Domains (1) summary

pfam13837
Location:79 → 126

Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain