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    Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII [ Mus musculus (house mouse) ]

    Gene ID: 22272, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Uqcrqprovided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase, complex III subunit VIIprovided by MGI
    Primary source
    MGI:MGI:107807
    See related
    Ensembl:ENSMUSG00000044894 AllianceGenome:MGI:107807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qpc; QP-C; Uqcrb; c1502; 9.5kDa; 1100001F06Rik; 1500040F11Rik; 5830407L17Rik
    Summary
    Predicted to enable ubiquinol-cytochrome-c reductase activity. Acts upstream of or within brain development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; integumental system; and nervous system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 291.7), liver adult (RPKM 266.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B1.3; 11 31.94 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (53318749..53321658, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (53427922..53430831, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 4 Neighboring gene microRNA 6920 Neighboring gene STARR-positive B cell enhancer ABC_E76 Neighboring gene liver-expressed antimicrobial peptide 2 Neighboring gene growth differentiation factor 9 Neighboring gene predicted gene 10447

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Weinberg SE, et al. Nature, 2019 Jan. PMID 30626970, Free PMC Article
    2. Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis. Wculek SK, et al. Immunity, 2023 Mar 14. PMID 36738738
    3. Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly. Zhang S, et al. Nat Commun, 2020 Mar 11. PMID 32161263, Free PMC Article
    4. Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain. Sadakata T, et al. Neurosci Lett, 2006 Sep 25. PMID 16901643
    5. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Ma W, et al. Sci Adv, 2021 Apr. PMID 33931446, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cerebellar Purkinje cell layer development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hippocampus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in hypothalamus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in midbrain development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in pons development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in pyramidal neuron development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in subthalamus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in thalamus development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex III ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome b-c1 complex subunit 8
    Names
    complex III subunit 8
    complex III subunit VII
    complex III subunit VIII
    low molecular mass ubiquinone-binding protein (Qpc-pending)
    ubiquinol-cytochrome c reductase binding protein
    ubiquinol-cytochrome c reductase complex 9.5 kDa protein
    ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
    NP_001313543.1
    NP_079628.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326614.1 → NP_001313543.1  cytochrome b-c1 complex subunit 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003160, AK005374, AL592489, CB950804
      Consensus CDS
      CCDS36151.1
      UniProtKB/Swiss-Prot
      Q9CQ69
      Related
      ENSMUSP00000104649.4, ENSMUST00000109021.4
      Conserved Domains (1) summary
      pfam02939
      Location:4 → 79
      UcrQ; UcrQ family

    2. NM_025352.3 → NP_079628.1  cytochrome b-c1 complex subunit 8

      See identical proteins and their annotated locations for NP_079628.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein
      Source sequence(s)
      AK005374, AK007982, AL592489, CB950804
      Consensus CDS
      CCDS36151.1
      UniProtKB/Swiss-Prot
      Q9CQ69
      Related
      ENSMUSP00000053145.5, ENSMUST00000061326.5
      Conserved Domains (1) summary
      pfam02939
      Location:4 → 79
      UcrQ; UcrQ family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      53318749..53321658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ69.3 GenPept UniProtKB/Swiss-Prot:Q9CQ69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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