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    Upp1 uridine phosphorylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 22271, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Upp1provided by MGI
    Official Full Name
    uridine phosphorylase 1provided by MGI
    Primary source
    MGI:MGI:1097668
    See related
    Ensembl:ENSMUSG00000020407 AllianceGenome:MGI:1097668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Up; Upp; UPase; UdRPase
    Summary
    Enables deoxyuridine phosphorylase activity; thymidine phosphorylase activity; and uridine phosphorylase activity. Involved in pyrimidine nucleoside monophosphate metabolic process and uridine catabolic process. Acts upstream of or within pyrimidine nucleotide metabolic process and uridine metabolic process. Located in cytosol. Is expressed in early embryo; extraembryonic ectoderm; nervous system; and sensory organ. Orthologous to human UPP1 (uridine phosphorylase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 191.4), small intestine adult (RPKM 74.3) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 A1; 11 6.13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (9068008..9086170)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (9118008..9136170)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene HUS1 checkpoint clamp component Neighboring gene Sad1 and UNC84 domain containing 3 Neighboring gene predicted gene 11992 Neighboring gene STARR-seq mESC enhancer starr_28553 Neighboring gene STARR-seq mESC enhancer starr_28555 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C pseudogene Neighboring gene ATP-binding cassette, sub-family A member 13 Neighboring gene STARR-seq mESC enhancer starr_28556 Neighboring gene STARR-seq mESC enhancer starr_28557 Neighboring gene STARR-seq mESC enhancer starr_28558 Neighboring gene STARR-seq mESC enhancer starr_28559 Neighboring gene STARR-seq mESC enhancer starr_28560 Neighboring gene STARR-seq mESC enhancer starr_28561 Neighboring gene STARR-seq mESC enhancer starr_28562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Uridine homeostatic disorder leads to DNA damage and tumorigenesis. Cao Z, et al. Cancer Lett, 2016 Mar 28. PMID 26801745
    2. Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity. Cao D, et al. Mol Cancer Ther, 2011 Dec. PMID 21954436, Free PMC Article
    3. SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES. KRENITSKY TA, et al. J Biol Chem, 1964 Mar. PMID 14154460
    4. Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines. Cao D, et al. Cancer Res, 2002 Apr 15. PMID 11956089
    5. Genomic structure, chromosomal mapping, and promoter region analysis of murine uridine phosphorylase gene. Cao D, et al. Cancer Res, 1999 Oct 1. PMID 10519414

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.
      Title: Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity.
    2. Data show that enhanced cytotoxicity of 5-FU by bFGF through modulating the expression of UPP1 at the transcription level.
      Title: Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.
    3. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
      Title: Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
    4. Taken together, the present study provides the first evidence that uridine protects neurons against ischemic insult-induced neuronal death, possibly through the action of UPase.
      Title: Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase.
    5. UPase is a critical enzyme in the regulation of uridine homeostasis and pyrimidine nucleotide metabolism, and 5-fluorouracil activity
      Title: Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene.
    6. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
      Title: Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyuridine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pentosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables thymidine phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables thymidine phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine phosphorylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uridine phosphorylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine phosphorylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables uridine phosphorylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UMP salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dCMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in dTMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dTMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dUMP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine nucleotide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in uridine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in uridine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in uridine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within uridine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uridine phosphorylase 1
    Names
    UPase 1
    urdPase 1
    NP_001152873.1
    NP_001152874.1
    NP_033503.2
    XP_006514730.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159401.1 → NP_001152873.1  uridine phosphorylase 1

      See identical proteins and their annotated locations for NP_001152873.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK136474, AV447018, BX527866
      Consensus CDS
      CCDS24432.1
      UniProtKB/Swiss-Prot
      P52624, Q8JZX0
      UniProtKB/TrEMBL
      Q5SUC8
      Related
      ENSMUSP00000099063.3, ENSMUST00000101525.9
      Conserved Domains (1) summary
      cd17763
      Location:32 → 306
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    2. NM_001159402.1 → NP_001152874.1  uridine phosphorylase 1

      See identical proteins and their annotated locations for NP_001152874.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK136474, BX527866, CA493594
      Consensus CDS
      CCDS24432.1
      UniProtKB/Swiss-Prot
      P52624, Q8JZX0
      UniProtKB/TrEMBL
      Q5SUC8
      Related
      ENSMUSP00000127473.2, ENSMUST00000164791.8
      Conserved Domains (1) summary
      cd17763
      Location:32 → 306
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    3. NM_009477.3 → NP_033503.2  uridine phosphorylase 1

      See identical proteins and their annotated locations for NP_033503.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      AK136474, AL118479, BX527866, CA536983
      Consensus CDS
      CCDS24432.1
      UniProtKB/Swiss-Prot
      P52624, Q8JZX0
      UniProtKB/TrEMBL
      Q5SUC8
      Related
      ENSMUSP00000020677.2, ENSMUST00000020677.8
      Conserved Domains (1) summary
      cd17763
      Location:32 → 306
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      9068008..9086170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514667.3 → XP_006514730.1  uridine phosphorylase 1 isoform X1

      See identical proteins and their annotated locations for XP_006514730.1

      UniProtKB/Swiss-Prot
      P52624, Q8JZX0
      UniProtKB/TrEMBL
      Q5SUC8
      Conserved Domains (1) summary
      cd17763
      Location:32 → 306
      UP_hUPP-like; uridine phosphorylases similar to a human UPP1 and UPP2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52624.2 GenPept UniProtKB/Swiss-Prot:P52624

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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