Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnfrsf4provided by MGI
Official Full Name: tumor necrosis factor receptor superfamily, member 4provided by MGI
Primary source: MGI:MGI:104512
See related: Ensembl:ENSMUSG00000029075 AllianceGenome:MGI:104512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Summary: Enables tumor necrosis factor-activated receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF receptor superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in frontal lobe adult (RPKM 42.7), genital fat pad adult (RPKM 36.8) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (156098049..156101070)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (156013595..156016613)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.
Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
Title: T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
Title: TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
Title: OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
Title: OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
Title: Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
Critical role of OX40 in drug-induced acute liver injury.
Title: Critical role of OX40 in drug-induced acute liver injury.
Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
Title: OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
Pulmonary group 2 innate lymphoid cells may regulate RSV-induced CD4+T cell expansion and activation via OX40/OX40L interaction. Our results might provide a novel understanding of the underlying mechanisms of respiratory tract diseases mediated by type 2 immunity and be useful to improve the insights and therapies for RSV-induced or RSV-aggravated asthma.
Title: Critical role of OX40/OX40L in ILC2-mediated activation of CD4(+)T cells during respiratory syncytial virus infection in mice.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (10)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mon25 (e-PCR)
- UniSTS:240989

D4Mon26 (e-PCR)
- UniSTS:240990

NoName (e-PCR)
- UniSTS:224731

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tumor necrosis factor receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of activation-induced cell death of T cells	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cytokine production	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within programmed cell death	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 4

Names: OX40 antigen; OX40L receptor; tax-transcriptionally activated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011659.2 → NP_035789.1 tumor necrosis factor receptor superfamily member 4 precursor

See identical proteins and their annotated locations for NP_035789.1

Status: PROVISIONAL

Source sequence(s)

AL627204

Consensus CDS

CCDS19055.1

UniProtKB/Swiss-Prot

P47741

UniProtKB/TrEMBL

B1ASL3

Related

ENSMUSP00000030952.6, ENSMUST00000030952.6

Conserved Domains (1) summary

cd13406
Location:25 → 168

TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

156098049..156101070

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006538724.4 → XP_006538787.3 tumor necrosis factor receptor superfamily member 4 isoform X1

Conserved Domains (1) summary

cd13406
Location:113 → 256

TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40