Ttn titin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttnprovided by MGI
Official Full Name: titinprovided by MGI
Primary source: MGI:MGI:98864
See related: Ensembl:ENSMUSG00000051747 AllianceGenome:MGI:98864
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: L56; mdm; shru; 1100001C23Rik; 2310036G12Rik; 2310057K23Rik; 2310074I15Rik; D330041I19Rik; D830007G01Rik
Summary: Enables ankyrin binding activity. Involved in regulation of relaxation of cardiac muscle. Acts upstream of or within several processes, including chordate embryonic development; forward locomotion; and heart development. Located in M band and Z disc. Is expressed in several structures, including diaphragm; embryo mesenchyme; heart; musculature; and tarsus. Used to study autosomal recessive limb-girdle muscular dystrophy type 2J; dilated cardiomyopathy 1G; and tibial muscular dystrophy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 23.7), mammary gland adult (RPKM 4.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 45.13 cM

Exon count:: 350

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (76534324..76812901, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (76703980..76982557, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.
Title: The TTN p. Tyr4418Ter mutation causes cardiomyopathy in human and mice.
Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness.
Title: Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness.
Urine titin as a novel biomarker for Duchenne muscular dystrophy.
Title: Urine titin as a novel biomarker for Duchenne muscular dystrophy.
Rbm20[DeltaRRM] Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness.
Title: Rbm20(ΔRRM) Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness.
Titin force in muscle cells alters lattice order, thick and thin filament protein formation.
Title: Titin force in muscle cells alters lattice order, thick and thin filament protein formation.
Active muscle stiffness is reduced during rapid unloading in muscles from TtnDelta112-158 mice with a large deletion to PEVK titin.
Title: Active muscle stiffness is reduced during rapid unloading in muscles from TtnΔ112-158 mice with a large deletion to PEVK titin.
Depletion of m(6) A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin.
Title: Depletion of m(6) A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin.
Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Title: Functional analysis of a gene-edited mouse model to gain insights into the disease mechanisms of a titin missense variant.
Titin M-line insertion sequence 7 is required for proper cardiac function in mice.
Title: Titin M-line insertion sequence 7 is required for proper cardiac function in mice.
Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions.
Title: Solution NMR Structure of Titin N2A Region Ig Domain I83 and Its Interaction with Metal Ions.

Submit: New GeneRIF Correction See all GeneRIFs (76)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (14) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Ucl5 (e-PCR), detects polymorphism
- UniSTS:142361

MARC_21540-21541:1033053987:1 (e-PCR)
- UniSTS:268573

AV006427 (e-PCR)
- UniSTS:165179

Ttn (e-PCR), detects polymorphism
- UniSTS:234062

RH98821 (e-PCR)
- UniSTS:85869

D2S1564E (e-PCR)
- UniSTS:150649

27.MMHAP20FRA12.seq (e-PCR)
- UniSTS:123776

D2Mit93 (e-PCR), detects polymorphism
- UniSTS:129489

RH126352 (e-PCR)
- UniSTS:163060

Ttn (e-PCR), detects polymorphism
- UniSTS:515322

D2Mit158 (e-PCR), detects polymorphism
- UniSTS:129019

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables muscle alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	TAS Traceable Author Statement more info	PubMed
enables structural constituent of muscle	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	ISO Inferred from Sequence Orthology more info
enables structural molecule activity conferring elasticity	ISO Inferred from Sequence Orthology more info
enables telethonin binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac myofibril assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of muscle stretch	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heart growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of relaxation of cardiac muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sarcomere organization	TAS Traceable Author Statement more info	PubMed
involved_in sarcomerogenesis	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle myosin thick filament assembly	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle thin filament assembly	ISO Inferred from Sequence Orthology more info
involved_in somitogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within striated muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in I band	ISO Inferred from Sequence Orthology more info
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info	PubMed
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of muscle myosin complex	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in striated muscle thin filament	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: titin

Names: connectin

NP_001372637.1

EC 2.7.11.1

NP_035782.3

EC 2.7.11.1

NP_082280.2

EC 2.7.11.1

XP_036016413.1

EC 2.7.11.1

XP_036016417.1

EC 2.7.11.1

XP_036016420.1

EC 2.7.11.1

XP_036016421.1

EC 2.7.11.1

XP_036016422.1

EC 2.7.11.1

XP_036016427.1

EC 2.7.11.1

XP_036016428.1

EC 2.7.11.1

XP_036016429.1

EC 2.7.11.1

XP_036016430.1

EC 2.7.11.1

XP_036016431.1

EC 2.7.11.1

XP_036016433.1

EC 2.7.11.1

XP_036016436.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001385708.1 → NP_001372637.1 titin isoform 3

Status: VALIDATED

Source sequence(s)

AL928681, AL928721, AL928789

UniProtKB/TrEMBL

A0A5K1VVQ9

Related

ENSMUSP00000097561.4, ENSMUST00000099981.10

Conserved Domains (22) summary

cd05747
Location:34545 → 34636

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

PTZ00449
Location:11550 → 11841

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

smart00060
Location:17485 → 17569

FN3; Fibronectin type 3 domain

smart00410
Location:14458 → 14522

IG_like; Immunoglobulin like

PHA03247
Location:11702 → 12305

PHA03247; large tegument protein UL36; Provisional

PRK12323
Location:253 → 346

PRK12323; DNA polymerase III subunit gamma/tau

cd00063
Location:26889 → 26981

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:33237 → 33513

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:13207 → 13275

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:20188 → 20190

Ig; Ig strand A [structural motif]

cd05748
Location:24143 → 24224

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:33556 → 33645

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

NF033839
Location:12149 → 12512

PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

cl11960
Location:20188 → 20281

Ig; Immunoglobulin domain
NM_011652.3 → NP_035782.3 titin isoform N2-A

Status: VALIDATED

Description

Transcript Variant: This variant (N2-A) represents the longer transcript and encodes the longer isoform (N2-A).

Source sequence(s)

AK029024, AK081896, AK084709, AK084780, AK085832, AK132562, AK139762, AK157782, AL928721, AL928789, BB532149, BG795347

Consensus CDS

CCDS38154.1

UniProtKB/TrEMBL

E9Q8K5, E9Q8N1

Related

ENSMUSP00000107477.3, ENSMUST00000111846.9

Conserved Domains (13) summary

cd00096
Location:4886 → 4954

Ig; Immunoglobulin domain

cd05747
Location:32601 → 32692

Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins

cd05748
Location:20042 → 20115

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:3757 → 3823

IGc2; Immunoglobulin C-2 Type

smart00060
Location:15541 → 15625

FN3; Fibronectin type 3 domain

smart00220
Location:31294 → 31548

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:30584 → 30663

IG; Immunoglobulin

smart00410
Location:27323 → 27405

IG_like; Immunoglobulin like

cd00063
Location:24945 → 25037

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:6265 → 6354

I-set; Immunoglobulin I-set domain

cd14104
Location:31293 → 31569

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam00047
Location:12513 → 12579

ig; Immunoglobulin domain

cl11960
Location:23685 → 23758

Ig; Immunoglobulin domain
NM_028004.2 → NP_082280.2 titin isoform N2-B

Status: VALIDATED

Description

Transcript Variant: This variant (N2-B) has multiple differences in the coding region compared to variant N2-A. The resulting isoform (N2-B) has the same N- and C-termini but is shorter compared to isoform N2-A.

Source sequence(s)

AK029024, AK081896, AK084709, AK084780, AK132562, AK157782, AL928721, AL928789, BB662000

UniProtKB/TrEMBL

A0A5K1VVQ1

Conserved Domains (13) summary

cd00096
Location:24012 → 24079

Ig; Immunoglobulin domain

cd05747
Location:26020 → 26111

Ig5_Titin_like; M5, fifth immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins

cd05748
Location:13461 → 13534

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

smart00408
Location:913 → 979

IGc2; Immunoglobulin C-2 Type

smart00060
Location:8960 → 9044

FN3; Fibronectin type 3 domain

smart00220
Location:24713 → 24967

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:20742 → 20824

IG; Immunoglobulin

smart00410
Location:24003 → 24082

IG_like; Immunoglobulin like

cd00063
Location:18364 → 18456

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:26024 → 26112

I-set; Immunoglobulin I-set domain

cd14104
Location:24712 → 24988

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam00047
Location:5932 → 5998

ig; Immunoglobulin domain

cl11960
Location:17104 → 17177

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

76534324..76812901 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160538.1 → XP_036016431.1 titin isoform X10

UniProtKB/TrEMBL

A0A5K1VVQ1

Related

ENSMUSP00000011934.7, ENSMUST00000011934.13

Conserved Domains (16) summary

cd05747
Location:26066 → 26157

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:25976 → 26710

PTZ00121; MAEBL; Provisional

smart00060
Location:9006 → 9090

FN3; Fibronectin type 3 domain

smart00410
Location:5979 → 6043

IG_like; Immunoglobulin like

cd00063
Location:18410 → 18502

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:24758 → 25034

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam07679
Location:946 → 1035

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:4728 → 4796

Ig_3; Immunoglobulin domain

cd00096
Location:11709 → 11711

Ig; Ig strand A [structural motif]

cd05748
Location:15664 → 15745

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:25077 → 25166

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:11709 → 11802

Ig; Immunoglobulin domain
XM_036160537.1 → XP_036016430.1 titin isoform X9

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (19) summary

cd05747
Location:32372 → 32463

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:32282 → 33016

PTZ00121; MAEBL; Provisional

smart00060
Location:15312 → 15396

FN3; Fibronectin type 3 domain

smart00409
Location:12285 → 12349

IG; Immunoglobulin

smart00410
Location:11127 → 11191

IG_like; Immunoglobulin like

cd00063
Location:24716 → 24808

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31064 → 31340

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:10535 → 10559

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11034 → 11102

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18015 → 18017

Ig; Ig strand A [structural motif]

cd05748
Location:21970 → 22051

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:31383 → 31472

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18015 → 18108

Ig; Immunoglobulin domain
XM_036160536.1 → XP_036016429.1 titin isoform X8

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (18) summary

cd05747
Location:32843 → 32934

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:32753 → 33487

PTZ00121; MAEBL; Provisional

smart00060
Location:15783 → 15867

FN3; Fibronectin type 3 domain

smart00410
Location:12756 → 12820

IG_like; Immunoglobulin like

cd00063
Location:25187 → 25279

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31535 → 31811

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11006 → 11030

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11505 → 11573

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18486 → 18488

Ig; Ig strand A [structural motif]

cd05748
Location:21070 → 21149

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:31854 → 31943

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18486 → 18579

Ig; Immunoglobulin domain
XM_036160535.1 → XP_036016428.1 titin isoform X7

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (18) summary

cd05747
Location:32873 → 32964

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:15813 → 15897

FN3; Fibronectin type 3 domain

smart00410
Location:12786 → 12850

IG_like; Immunoglobulin like

cd00063
Location:25217 → 25309

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31565 → 31841

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11036 → 11060

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11535 → 11603

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18516 → 18518

Ig; Ig strand A [structural motif]

cd05748
Location:21100 → 21179

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:31884 → 31973

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18516 → 18609

Ig; Immunoglobulin domain
XM_036160534.1 → XP_036016427.1 titin isoform X6

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (19) summary

cd05747
Location:32899 → 32990

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:15839 → 15923

FN3; Fibronectin type 3 domain

smart00409
Location:12812 → 12876

IG; Immunoglobulin

smart00410
Location:11654 → 11718

IG_like; Immunoglobulin like

cd00063
Location:25243 → 25335

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31591 → 31867

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11561 → 11629

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18542 → 18544

Ig; Ig strand A [structural motif]

cd05748
Location:21126 → 21205

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:31910 → 31999

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18542 → 18635

Ig; Immunoglobulin domain
XM_036160529.1 → XP_036016422.1 titin isoform X5

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (19) summary

cd05747
Location:33012 → 33103

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:15952 → 16036

FN3; Fibronectin type 3 domain

smart00409
Location:12925 → 12989

IG; Immunoglobulin

smart00410
Location:11767 → 11831

IG_like; Immunoglobulin like

cd00063
Location:25356 → 25448

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31704 → 31980

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11674 → 11742

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18655 → 18657

Ig; Ig strand A [structural motif]

cd05748
Location:22610 → 22691

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:32023 → 32112

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18655 → 18748

Ig; Immunoglobulin domain
XM_036160528.1 → XP_036016421.1 titin isoform X4

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (19) summary

cd05747
Location:33216 → 33307

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:16156 → 16240

FN3; Fibronectin type 3 domain

smart00410
Location:13129 → 13193

IG_like; Immunoglobulin like

COG0810
Location:11065 → 11134

TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]

cd00063
Location:25560 → 25652

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:31908 → 32184

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:11878 → 11946

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:18859 → 18861

Ig; Ig strand A [structural motif]

cd05748
Location:22814 → 22895

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:32227 → 32316

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:18859 → 18952

Ig; Immunoglobulin domain
XM_036160527.1 → XP_036016420.1 titin isoform X3

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (20) summary

cd05747
Location:33374 → 33465

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:16314 → 16398

FN3; Fibronectin type 3 domain

smart00409
Location:13287 → 13351

IG; Immunoglobulin

smart00410
Location:12129 → 12193

IG_like; Immunoglobulin like

COG0810
Location:11065 → 11134

TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]

cd00063
Location:25718 → 25810

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:32066 → 32342

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:12036 → 12104

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:19017 → 19019

Ig; Ig strand A [structural motif]

cd05748
Location:22972 → 23053

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:32385 → 32474

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:19017 → 19110

Ig; Immunoglobulin domain
XM_036160524.1 → XP_036016417.1 titin isoform X2

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (19) summary

cd05747
Location:33402 → 33493

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:16342 → 16426

FN3; Fibronectin type 3 domain

smart00410
Location:13315 → 13379

IG_like; Immunoglobulin like

COG0810
Location:11065 → 11134

TonB; Periplasmic protein TonB, links inner and outer membranes [Cell wall/membrane/envelope biogenesis]

cd00063
Location:25746 → 25838

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:32094 → 32370

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:11062 → 11086

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:12064 → 12132

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:19045 → 19047

Ig; Ig strand A [structural motif]

cd05748
Location:23000 → 23081

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:32413 → 32502

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:19045 → 19138

Ig; Immunoglobulin domain
XM_036160520.1 → XP_036016413.1 titin isoform X1

UniProtKB/TrEMBL

A0A5K1VVQ9

Conserved Domains (21) summary

cd05747
Location:34249 → 34340

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:10208 → 10736

PTZ00121; MAEBL; Provisional

smart00060
Location:17189 → 17273

FN3; Fibronectin type 3 domain

smart00410
Location:14162 → 14226

IG_like; Immunoglobulin like

PHA03247
Location:11786 → 12205

PHA03247; large tegument protein UL36; Provisional

PRK12323
Location:253 → 346

PRK12323; DNA polymerase III subunit gamma/tau

cd00063
Location:26593 → 26685

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:32941 → 33217

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam02818
Location:12303 → 12329

PPAK; PPAK motif

pfam07679
Location:7284 → 7373

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:12911 → 12979

Ig_3; Immunoglobulin domain

pfam18362
Location:9591 → 9621

THB; Tri-helix bundle domain

cd00096
Location:19892 → 19894

Ig; Ig strand A [structural motif]

cd05748
Location:23847 → 23928

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:33260 → 33349

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

NF033839
Location:11571 → 11977

PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

cl11960
Location:19892 → 19985

Ig; Immunoglobulin domain
XM_036160540.1 → XP_036016433.1 titin isoform X11

UniProtKB/TrEMBL

A0A5K1VVQ1

Conserved Domains (12) summary

cd05747
Location:21829 → 21920

IgI_Titin_like; Immunoglobulin (Ig)-like domain of human titin C terminus and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

PTZ00121
Location:21739 → 22473

PTZ00121; MAEBL; Provisional

smart00060
Location:4769 → 4853

FN3; Fibronectin type 3 domain

smart00410
Location:1742 → 1806

IG_like; Immunoglobulin like

cd00063
Location:14173 → 14265

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14104
Location:20521 → 20797

STKc_Titin; Catalytic domain of the Giant Serine/Threonine Kinase Titin

pfam07679
Location:22457 → 22546

I-set; Immunoglobulin I-set domain

pfam13927
Location:491 → 559

Ig_3; Immunoglobulin domain

cd00096
Location:7472 → 7474

Ig; Ig strand A [structural motif]

cd05748
Location:11427 → 11508

Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins

cd20927
Location:20840 → 20929

IgI_Titin_M1-like; Immunoglobulin-like M1 domain from Titin; a member of the I-set of IgSF domains

cl11960
Location:7472 → 7565

Ig; Immunoglobulin domain
XM_036160543.1 → XP_036016436.1 titin isoform X12

Related

ENSMUSP00000097560.4, ENSMUST00000099980.10

Conserved Domains (9) summary

PHA03307
Location:242 → 378

PHA03307; transcriptional regulator ICP4; Provisional

pfam07679
Location:946 → 1035

I-set; Immunoglobulin I-set domain

pfam09042
Location:465 → 504

Titin_Z; Titin Z

pfam13927
Location:3508 → 3589

Ig_3; Immunoglobulin domain

cd00096
Location:3245 → 3247

Ig; Ig strand A [structural motif]

cd20951
Location:2084 → 2175

IgI_titin_I1-like; Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains

cd20972
Location:103 → 193

IgI_2_Titin_Z1z2-like; Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains

cd20974
Location:6 → 98

IgI_1_Titin_Z1z2-like; First Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins; a member of the I-set of IgSF domains

cl11960
Location:3245 → 3335

Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_027369.1: Suppressed sequence

Description

NM_027369.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.