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    Tsks testis-specific serine kinase substrate [ Mus musculus (house mouse) ]

    Gene ID: 22116, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tsksprovided by MGI
    Official Full Name
    testis-specific serine kinase substrateprovided by MGI
    Primary source
    MGI:MGI:1347560
    See related
    Ensembl:ENSMUSG00000059891 AllianceGenome:MGI:1347560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tssks1; Stk22s1
    Summary
    This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis adult (RPKM 199.6) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 B3; 7 29.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44579044..44607465)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44929472..44958041)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation. Shimada K, et al. Proc Natl Acad Sci U S A, 2023 Mar 14. PMID 36881620, Free PMC Article
    2. PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis. MacLeod G, et al. Reproduction, 2014 Jan. PMID 24088291
    3. Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases. Shang P, et al. J Cell Sci, 2010 Feb 1. PMID 20053632
    4. A novel family of serine/threonine kinases participating in spermiogenesis. Kueng P, et al. J Cell Biol, 1997 Dec 29. PMID 9412477, Free PMC Article
    5. TSKS concentrates in spermatid centrioles during flagellogenesis. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18495105, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.
      Title: TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.
    2. In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS. Interaction between PPP1CC2 and TSKS is mediated through an RVxF docking motif on the TSKS surface.
      Title: PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
    3. In elongating spermatids, data detected accumulation of the testis-specific TSSK1 and TSSK2, and the substrate TSKS, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite.
      Title: Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148222

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine kinase substrate
    Names
    STK22 substrate 1
    clone 4
    serine/threonine kinase 22 substrate 1
    testis-specific kinase substrate
    testis-specific serine/threonine kinase substrate 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077591.1 → NP_001071059.1  testis-specific serine kinase substrate isoform 2

      See identical proteins and their annotated locations for NP_001071059.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple in-frame differences in the coding region, compared to variant 1, which results in a shorter protein (isoform 2).
      Source sequence(s)
      BC121827, BX630702, CJ047818
      Consensus CDS
      CCDS39946.1
      UniProtKB/TrEMBL
      Q147V4
      Related
      ENSMUSP00000079122.7, ENSMUST00000080233.9
      Conserved Domains (1) summary
      pfam15358
      Location:26 → 525
      TSKS; Testis-specific serine kinase substrate

    2. NM_001417444.1 → NP_001404373.1  testis-specific serine kinase substrate isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC155806

    3. NM_001417445.1 → NP_001404374.1  testis-specific serine kinase substrate isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC155806, AC158231

    4. NM_001417446.1 → NP_001404375.1  testis-specific serine kinase substrate isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC155806, AC158231

    5. NM_011651.2 → NP_035781.2  testis-specific serine kinase substrate isoform 1

      See identical proteins and their annotated locations for NP_035781.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
      Source sequence(s)
      BC121827, BX630702, CJ047818, CN831975
      Consensus CDS
      CCDS52240.1
      UniProtKB/Swiss-Prot
      E9QJS9, O54887
      Related
      ENSMUSP00000112673.2, ENSMUST00000120929.9
      Conserved Domains (1) summary
      pfam15358
      Location:26 → 585
      TSKS; Testis-specific serine kinase substrate

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      44579044..44607465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540793.5 → XP_006540856.1  testis-specific serine kinase substrate isoform X3

      Conserved Domains (1) summary
      pfam15358
      Location:15 → 580
      TSKS; Testis-specific serine kinase substrate

    2. XM_006540791.3 → XP_006540854.1  testis-specific serine kinase substrate isoform X1

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 610
      TSKS; Testis-specific serine kinase substrate

    3. XM_006540792.3 → XP_006540855.1  testis-specific serine kinase substrate isoform X2

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 601
      TSKS; Testis-specific serine kinase substrate

    4. XM_006540796.3 → XP_006540859.1  testis-specific serine kinase substrate isoform X6

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 573
      TSKS; Testis-specific serine kinase substrate

    5. XM_006540794.3 → XP_006540857.1  testis-specific serine kinase substrate isoform X4

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 576
      TSKS; Testis-specific serine kinase substrate

    6. XM_006540795.4 → XP_006540858.1  testis-specific serine kinase substrate isoform X5

      Conserved Domains (1) summary
      pfam15358
      Location:26 → 492
      TSKS; Testis-specific serine kinase substrate
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54887.4 GenPept UniProtKB/Swiss-Prot:O54887

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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