Phlda2 pleckstrin homology like domain, family A, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phlda2provided by MGI
Official Full Name: pleckstrin homology like domain, family A, member 2provided by MGI
Primary source: MGI:MGI:1202307
See related: Ensembl:ENSMUSG00000010760 AllianceGenome:MGI:1202307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ipl; Tssc3
Summary: This gene is one of several genes in the imprinted gene domain on chromosome 7. Studies using knockout mice have shown that the product of this gene regulates placental growth. Transcripts from this gene are most abundant in placenta and yolk sac, and are almost entirely transcribed from the maternal allele. [provided by RefSeq, Jul 2008]
Expression: Biased expression in placenta adult (RPKM 163.8), kidney adult (RPKM 10.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 88.23 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (143055282..143056882, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (143501545..143503145, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
Title: PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.
Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse.
Title: Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse.
Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.
Title: The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources.
data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve
Title: Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice.
TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT/MASH2 signaling pathway.
Title: The maternally expressed gene Tssc3 regulates the expression of MASH2 transcription factor in mouse trophoblast stem cells through the AKT-Sp1 signaling pathway.
Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.
Title: Placental growth retardation due to loss of imprinting of Phlda2.
A critical role for the imprinted Phlda2 gene in regulating glycogen storage in the eutherian placenta is identified.
Title: The imprinted Phlda2 gene regulates extraembryonic energy stores.
Embryonic expression of Ipl in mice
Title: The expression of the imprinted gene Ipl is restricted to extra-embryonic tissues and embryonic lateral mesoderm during early mouse development.
Ipl and Tih1 are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs.
Title: Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1.
deletion causes placental overgrowth
Title: Placental overgrowth in mice lacking the imprinted gene Ipl.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Phlda2 (e-PCR), detects polymorphism
- UniSTS:516145

Tssc3 (e-PCR), detects polymorphism
- UniSTS:144692

Tssc3 (e-PCR), detects polymorphism
- UniSTS:144693

Phlda2 (e-PCR), detects polymorphism
- UniSTS:516467

Phlda2 (e-PCR), detects polymorphism
- UniSTS:516487

NoName (e-PCR)
- UniSTS:532156

Phlda2 (e-PCR), detects polymorphism
- UniSTS:532156

Phlda2 (e-PCR), detects polymorphism
- UniSTS:516570

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in placenta development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within placenta development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of embryonic development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of glycogen metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of growth hormone activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pleckstrin homology-like domain family A member 2

Names: imprinted in placenta and liver protein; protein 50C15; tumor-suppressing subchromosomal transferable fragment 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009434.2 → NP_033460.1 pleckstrin homology-like domain family A member 2

See identical proteins and their annotated locations for NP_033460.1

Status: REVIEWED

Source sequence(s)

CF615806, CF617643, Y15443

Consensus CDS

CCDS22042.1

UniProtKB/Swiss-Prot

O08969

Related

ENSMUSP00000010904.4, ENSMUST00000010904.5

Conserved Domains (1) summary

pfam17339
Location:22 → 104

DUF5369; Family of unknown function (DUF5369)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

143055282..143056882 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508597.2 → XP_006508660.1 pleckstrin homology-like domain family A member 2 isoform X1

See identical proteins and their annotated locations for XP_006508660.1

UniProtKB/Swiss-Prot

O08969

Conserved Domains (1) summary

pfam17339
Location:22 → 104

DUF5369; Family of unknown function (DUF5369)