Tsn translin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsnprovided by MGI
Official Full Name: translinprovided by MGI
Primary source: MGI:MGI:109263
See related: Ensembl:ENSMUSG00000026374 AllianceGenome:MGI:109263
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C3PO; TB-RBP; 2610034C24Rik
Summary: Enables mRNA binding activity. Predicted to be involved in RNA metabolic process. Located in cytoplasm and nucleus. Orthologous to human TSN (translin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 26.5), CNS E14 (RPKM 24.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E2.3; 1 52.14 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (118226244..118239463, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (118298514..118311461, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation.
Title: Functional characterization of testis-brain RNA-binding protein, TB-RBP/Translin, in translational regulation.
Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
Title: Selective role of the translin/trax RNase complex in hippocampal synaptic plasticity.
Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
Title: Genetic inactivation of the translin/trax microRNA-degrading enzyme phenocopies the robust adiposity induced by Translin (Tsn) deletion.
Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.
Title: Deletion of translin (Tsn) induces robust adiposity and hepatic steatosis without impairing glucose tolerance.
Primary cultures of Translin-null mammary epithelial cells showed augmented DNA synthesis in a ligand-independent and ligand-enhanced manner. Translin-null ovariectomized mice implanted with slow-release estrogen pellets showed enhanced length and ramification of the mammary glands.
Title: Translin restricts the growth of pubertal mammary epithelial cells estrogen-independently in mice.
Deletion of the TN/TX complex selectively increases aortic miR-181b and prevents increased vascular stiffness caused by ingestion of high-salt water.
Title: Deletion of the microRNA-degrading nuclease, translin/trax, prevents pathogenic vascular stiffness.
Translin plays an intrinsic role in restricting mesenchymal cell proliferation and differentiation
Title: Translin modulates mesenchymal cell proliferation and differentiation in mice.
Thus, the authors define a new memory mechanism by which learning reverses microRNA-mediated silencing of the novel plasticity protein ACVR1C via translin/trax.
Title: Learning induces the translin/trax RNase complex to express activin receptors for persistent memory.
These findings indicate that miRNA depletion in dicer deficiency is due to the combined loss of miRNA-generating activity and catabolic function of TN/TX.
Title: Rescuing dicer defects via inhibition of an anti-dicing nuclease.
These in vivo and in vitro findings of this study indicated that dendritic trafficking of BDNF mRNA can be mediated by both translin-dependent and -independent mechanisms.
Title: Dendritic trafficking of brain-derived neurotrophic factor mRNA: regulation by translin-dependent and -independent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
contributes_to sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	NAS Non-traceable Author Statement more info	PubMed
involved_in siRNA processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of endoribonuclease complex	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: translin

Names: component 3 of promoter of RISC; testis/brain-RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011650.4 → NP_035780.1 translin

See identical proteins and their annotated locations for NP_035780.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer, protein-coding variant.

Source sequence(s)

AC121531, CX243508

Consensus CDS

CCDS35690.1

UniProtKB/Swiss-Prot

Q62348

UniProtKB/TrEMBL

Q545E6

Related

ENSMUSP00000027623.8, ENSMUST00000027623.9

Conserved Domains (1) summary

cd14819
Location:10 → 216

Translin; also known as TB-RBP (testis brain RNA-binding protein)

RNA

NR_153836.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' end compared to variant 1. This variant is represented as non-coding because it lacks the translational start codon and a believable ORF, compared to variant 1.

Source sequence(s)

AC121531

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

118226244..118239463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252998.2 → XP_030108858.1 translin isoform X1

Conserved Domains (1) summary

cl00957
Location:10 → 126

Translin-like; Translin and translin-associated factor-X (TRAX)