Trpc5 transient receptor potential cation channel, subfamily C, member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpc5provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily C, member 5provided by MGI
Primary source: MGI:MGI:109524
See related: Ensembl:ENSMUSG00000041710 AllianceGenome:MGI:109524
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CCE2; TRP5; TRP-5; Trrp5
Summary: Enables inositol 1,4,5 trisphosphate binding activity. Involved in neuron apoptotic process and phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Predicted to be part of calcium channel complex. Predicted to be integral component of plasma membrane. Is expressed in brain; cochlea; dorsal root ganglion; and vagus ganglion. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 1.2), frontal lobe adult (RPKM 1.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F2; X 65.49 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (143160323..143471176, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (144377327..144688180, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.
Title: The SphK1/S1P Axis Regulates Synaptic Vesicle Endocytosis via TRPC5 Channels.
The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5.
Title: The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5.
TRPC5 mediates endothelium-dependent contraction in the carotid artery of diet-induced obese mice.
Title: TRPC5 mediates endothelium-dependent contraction in the carotid artery of diet-induced obese mice.
Trpc5-regulated AMPKalpha/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
Title: Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation.
Title: TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation.
Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
Title: Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.
Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
Title: Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
TRPC5 regulates axonal outgrowth in developing retinal ganglion cells.
Title: TRPC5 regulates axonal outgrowth in developing retinal ganglion cells.
Data suggest that TRPC5 ion channel permeation has little or no effect on atherosclerosis or steatosis but an unexpected major effect on weight gain and adipocyte expansion.
Title: TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpc5 (e-PCR), detects polymorphism
- UniSTS:546050

Trpc5 (e-PCR), detects polymorphism
- UniSTS:531242

Trrp5 (e-PCR), detects polymorphism
- UniSTS:144686

AF029983 (e-PCR)
- UniSTS:181339

Trpc5 (e-PCR), detects polymorphism
- UniSTS:516716

DXMit118 (e-PCR), detects polymorphism
- UniSTS:132009

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine exposure on apoptotic cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: short transient receptor potential channel 5

Names: capacitative calcium entry channel 2; transient receptor protein 5; trp-related protein 5; vtransient receptor potential cation channel, subfamily C, member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009428.3 → NP_033454.1 short transient receptor potential channel 5

See identical proteins and their annotated locations for NP_033454.1

Status: VALIDATED

Source sequence(s)

AK038531, AK047867, AL713978, AL731701

Consensus CDS

CCDS30457.1

UniProtKB/Swiss-Prot

Q61059, Q9QWT1, Q9QX29, Q9R0D4

UniProtKB/TrEMBL

Q2KHN9, Q8C8A8

Related

ENSMUSP00000049063.4, ENSMUST00000040184.4

Conserved Domains (4) summary

cd00204
Location:35 → 162

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:17 → 756

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:176 → 235

TRP_2; Transient receptor ion channel II

sd00045
Location:69 → 98

ANK; ANK repeat [structural motif]