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    Trhr thyrotropin releasing hormone receptor [ Mus musculus (house mouse) ]

    Gene ID: 22045, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Trhrprovided by MGI
    Official Full Name
    thyrotropin releasing hormone receptorprovided by MGI
    Primary source
    MGI:MGI:98824
    See related
    Ensembl:ENSMUSG00000038760 AllianceGenome:MGI:98824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRH-R1
    Summary
    Predicted to enable identical protein binding activity and thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of protein-containing complex assembly. Predicted to act upstream of or within signal transduction. Predicted to be located in cell surface. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skeleton. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 7 and hypertension. Orthologous to human TRHR (thyrotropin releasing hormone receptor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Trhr in Genome Data Viewer
    Location:
    15 B3.2; 15 16.82 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44059314..44099308)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (44195924..44235912)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38558 Neighboring gene STARR-seq mESC enhancer starr_38559 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene transmembrane protein 74 Neighboring gene STARR-seq mESC enhancer starr_38560 Neighboring gene STARR-seq mESC enhancer starr_38561 Neighboring gene STARR-seq mESC enhancer starr_38563 Neighboring gene STARR-seq mESC enhancer starr_38565 Neighboring gene STARR-seq mESC enhancer starr_38567 Neighboring gene predicted gene, 33793 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2. Deflorian F, et al. Proteins, 2008 May 1. PMID 17979196
    2. Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches. Huang W, et al. Biochemistry, 2005 Feb 22. PMID 15709754
    3. Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Rabeler R, et al. Mol Endocrinol, 2004 Jun. PMID 14988432
    4. Characterization of the thyrotropin binding pocket. Jeffreys J, et al. Thyroid, 2002 Dec. PMID 12593718
    5. An alternative splice variant of the mouse TRH receptor mRNA is the major form expressed in the mouse pituitary gland. Jones KE, et al. J Mol Endocrinol, 1996 Apr. PMID 9156522

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. activating TRH/TRH-R1 signaling seems not to be sufficient for gastric stimulation of acylated ghrelin production
      Title: Absence of TRH receptor 1 in male mice affects gastric ghrelin production.
    2. The central nervous systems effects of taltirelin are mediated primarily by TRH-R1 and not TRH-R2.
      Title: Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice.
    3. We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1.
      Title: Persistent signaling by thyrotropin-releasing hormone receptors correlates with G-protein and receptor levels.
    4. Direct TRH receptor-mediated excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange.
      Title: Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone.
    5. A flexible molecular docking procedure revealed that TRH establishes a direct interaction with W6.48 in TRH-R2 but not in TRH-R1.
      Title: Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2.
    6. the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways
      Title: Thyrotropin-releasing hormone receptor 1-deficient mice display increased depression and anxiety-like behavior.
    7. Thyrotropin-releasing hormone binding induces separation of cytoplasmic ends of TRH receptor type 1 transmembrane helix 5 (TMH5) and TMH6 and a rotation of TMH6 that could promote interactions between G proteins and key residues within the TRH receptor.
      Title: Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches.
    8. three distinct and discontinuous regions of the TSHR (aa 246-260 and 277-296 on the TSHR A subunit) and aa 381-385 (on the TSHR B subunit) fold together to form a complex TSH binding pocket.
      Title: Characterization of the thyrotropin binding pocket.
    9. the TSHR may not be similar to other model proteins used to define the concept of central immune tolerance.
      Title: Thyrotropin receptor knockout mice: studies on immunological tolerance to a major thyroid autoantigen.
    10. TRH-R1 has a role in mouse lactation and mice lacking the receptor show signs of central hypothyroidism
      Title: Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124380, MGC124381

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables thyrotropin-releasing hormone receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyrotropin-releasing hormone receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thyrotropin-releasing hormone receptor
    Names
    TRH-R
    thyroliberin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013696.2 → NP_038724.1  thyrotropin-releasing hormone receptor

      See identical proteins and their annotated locations for NP_038724.1

      Status: VALIDATED

      Source sequence(s)
      AC132870, BB653069, BC128269
      Consensus CDS
      CCDS37068.1
      UniProtKB/Swiss-Prot
      P21761
      UniProtKB/TrEMBL
      Q32MS1, Q3UYL6
      Related
      ENSMUSP00000036320.7, ENSMUST00000038856.14
      Conserved Domains (2) summary
      pfam00001
      Location:42 → 320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:33 → 165
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      44059314..44099308
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520748.3 → XP_006520811.1  thyrotropin-releasing hormone receptor isoform X1

      Conserved Domains (2) summary
      cd14964
      Location:27 → 53
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:26 → 219
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21761.1 GenPept UniProtKB/Swiss-Prot:P21761

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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