Trf transferrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trfprovided by MGI
Official Full Name: transferrinprovided by MGI
Primary source: MGI:MGI:98821
See related: Ensembl:ENSMUSG00000032554 AllianceGenome:MGI:98821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HP; Tf; Tfn; hpx; Cd176
Summary: Predicted to enable iron chaperone activity; iron ion binding activity; and transferrin receptor binding activity. Involved in several processes, including ERK1 and ERK2 cascade; osteoclast differentiation; and positive regulation of bone resorption. Acts upstream of or within SMAD protein signal transduction; iron ion transport; and response to bacterium. Located in clathrin-coated pit and cytoplasmic vesicle. Is expressed in several structures, including brain; liver; placenta; white fat; and yolk sac. Used to study atransferrinemia. Human ortholog(s) of this gene implicated in anemia; atransferrinemia; glucose metabolism disease (multiple); iron deficiency anemia; and restless legs syndrome. Orthologous to human TF (transferrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 8144.6), liver adult (RPKM 3915.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 55.03 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (103086075..103107485, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (103208876..103230286, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Title: Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle.
Title: Loss of hepatic manganese transporter ZIP8 disrupts serum transferrin glycosylation and the glutamate-glutamine cycle.
TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution.
Title: TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution.
Transferrin plays a central role in coagulation balance by interacting with clotting factors.
Title: Transferrin plays a central role in coagulation balance by interacting with clotting factors.
Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Title: Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis.
Enhanced insulin receptor interaction by a bifunctional insulin-transferrin fusion protein: an approach to overcome insulin resistance.
Title: Enhanced insulin receptor interaction by a bifunctional insulin-transferrin fusion protein: an approach to overcome insulin resistance.
Transferrin binds and releases iron via either or both of 2 homologous lobes (N and C). Monoferric N and C transferrins demonstrate similar iron availability for heme but differential effects on erythropoiesis.
Title: Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis.
the value of transferrin receptors (TfRs)/cell reveals a 100-fold increase in the number of TfRs per bEnd3 cells compared to human umbilical vein cells.
Title: Energetics of ligand-receptor binding affinity on endothelial cells: An in vitro model.
Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38.
Title: Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38.
Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor.
Title: Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trf (e-PCR), detects polymorphism
- UniSTS:144667

BE132832 (e-PCR)
- UniSTS:208434

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

AI266983 (e-PCR)
- UniSTS:185804

D9Mit24 (e-PCR), detects polymorphism
- UniSTS:131804

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ferric iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables iron chaperone activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferrin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament organization	IDA Inferred from Direct Assay more info	PubMed
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in intracellular iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in iron ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of bone resorption	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte progenitor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of iron ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of HFE-transferrin receptor complex	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal part of cell	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell tip	ISO Inferred from Sequence Orthology more info
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dense body	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
part_of vesicle coat	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: serotransferrin

Names: beta-1 metal-binding globulin; hypotransferrinemia with hemochromatosis; siderophilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133977.2 → NP_598738.1 serotransferrin precursor

See identical proteins and their annotated locations for NP_598738.1

Status: PROVISIONAL

Source sequence(s)

AC156633

Consensus CDS

CCDS23451.1

UniProtKB/Swiss-Prot

O35421, Q3UBW7, Q58E69, Q61803, Q62357, Q62358, Q62359, Q63915, Q64515, Q8VII5, Q921I1, Q922C0

Related

ENSMUSP00000035158.10, ENSMUST00000035158.16

Conserved Domains (4) summary

smart00094
Location:360 → 682

TR_FER; Transferrin

cd13617
Location:359 → 681

PBP2_transferrin_C; The C-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

cd13618
Location:24 → 344

PBP2_transferrin_N; The N-lobe of transferrin, a member of the type 2 periplasmic binding protein fold superfamily

pfam00405
Location:25 → 347

Transferrin; Transferrin