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    Tpo thyroid peroxidase [ Mus musculus (house mouse) ]

    Gene ID: 22018, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tpoprovided by MGI
    Official Full Name
    thyroid peroxidaseprovided by MGI
    Primary source
    MGI:MGI:98813
    See related
    Ensembl:ENSMUSG00000020673 AllianceGenome:MGI:98813
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Tpo in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30104658..30182983, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30054659..30132984, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1-like Neighboring gene predicted gene, 46346 Neighboring gene predicted gene, 31939 Neighboring gene STARR-seq mESC enhancer starr_31838 Neighboring gene peroxidasin Neighboring gene STARR-seq mESC enhancer starr_31839 Neighboring gene STARR-seq mESC enhancer starr_31840 Neighboring gene STARR-seq mESC enhancer starr_31841 Neighboring gene predicted gene 15691 Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene. Johnson KR, et al. J Assoc Res Otolaryngol, 2014 Feb. PMID 24297261, Free PMC Article
    2. A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse. Takabayashi S, et al. Mol Endocrinol, 2006 Oct. PMID 16762971
    3. Ascidian homologs of mammalian thyroid peroxidase genes are expressed in the thyroid-equivalent region of the endostyle. Ogasawara M, et al. J Exp Zool, 1999 Aug 15. PMID 10440727
    4. Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase. Kotani T, et al. Gene, 1993 Jan 30. PMID 7916704
    5. Normal peroxidase activity in Pendred's syndrome. Burrow GN, et al. J Clin Endocrinol Metab, 1973 Mar. PMID 4346605

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
      Title: Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
    2. Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
      Title: Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
    3. Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
      Title: Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
    4. A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
      Title: A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iodide peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hormone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hydrogen peroxide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    thyroid peroxidase
    NP_033443.1
    XP_011242158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009417.3 → NP_033443.1  thyroid peroxidase precursor

      See identical proteins and their annotated locations for NP_033443.1

      Status: REVIEWED

      Source sequence(s)
      AC157276, X60703
      Consensus CDS
      CCDS25857.1
      UniProtKB/Swiss-Prot
      P35419, Q8C8B1
      Related
      ENSMUSP00000021005.9, ENSMUST00000021005.15
      Conserved Domains (4) summary
      cd00033
      Location:730 → 783
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:161 → 722
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      pfam03098
      Location:145 → 687
      An_peroxidase; Animal haem peroxidase
      pfam07645
      Location:784 → 826
      EGF_CA; Calcium-binding EGF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30104658..30182983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243856.3 → XP_011242158.1  thyroid peroxidase isoform X1

      Conserved Domains (3) summary
      cd00033
      Location:730 → 783
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd09825
      Location:161 → 722
      thyroid_peroxidase; Thyroid peroxidase (TPO)
      pfam07645
      Location:784 → 826
      EGF_CA; Calcium-binding EGF domain

    RNA

    1. XR_003950045.1 RNA Sequence

    2. XR_872405.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35419.1 GenPept UniProtKB/Swiss-Prot:P35419

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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