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    Ppp1r13b protein phosphatase 1, regulatory subunit 13B [ Mus musculus (house mouse) ]

    Gene ID: 21981, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp1r13bprovided by MGI
    Official Full Name
    protein phosphatase 1, regulatory subunit 13Bprovided by MGI
    Primary source
    MGI:MGI:1336199
    See related
    Ensembl:ENSMUSG00000021285 AllianceGenome:MGI:1336199
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p85; ASPP1; Tp53bp2; Trp53bp2
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including blood; brain; cardiovascular system; embryo mesenchyme; and yolk sac. Orthologous to human PPP1R13B (protein phosphatase 1 regulatory subunit 13B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 13.8), genital fat pad adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 61.14 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111794892..111874549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111828457..111908119, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21 Neighboring gene predicted gene, 53769 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:113090021-113090249 Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4 pseudogene Neighboring gene predicted gene, 57592 Neighboring gene predicted gene, 40898 Neighboring gene high mobility group box 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury. Yang Y, et al. Circ Res, 2023 Jan 20. PMID 36656967, Free PMC Article
    2. Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation. Yamashita M, et al. Cell Stem Cell, 2015 Jul 2. PMID 26119234
    3. Gene-trap expression screening to identify endothelial-specific genes. Hirashima M, et al. Blood, 2004 Aug 1. PMID 15090446
    4. ASPP: a new family of oncogenes and tumour suppressor genes. Sullivan A, et al. Br J Cancer, 2007 Jan 29. PMID 17211478, Free PMC Article
    5. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Fang DF, et al. Nat Commun, 2014 Jul 29. PMID 25072696

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
      Title: Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury.
    2. After genotoxic stress, Aspp1 promotes hematopoietic stem cell (HSC) cycling and induces p53-dependent apoptosis in cells with persistent DNA damage foci. Aspp1 also attenuates HSC self-renewal and accumulation of DNA damage in p53 null HSCs.
      Title: Aspp1 Preserves Hematopoietic Stem Cell Pool Integrity and Prevents Malignant Transformation.
    3. Our study demonstrates a novel role for ASPP1 and ASPP2 in the death of retinal ganglion cells.
      Title: ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo.
    4. Aspp1 plays a crucial role in the initial assembly and function of lymphatic vessels during mouse development in a p53-independent manner.
      Title: Lymphatic vessel assembly is impaired in Aspp1-deficient mouse embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-stimulating of p53 protein 1
    Names
    protein phosphatase 1, regulatory (inhibitor) subunit 13B
    transformation related protein 53 binding protein 2
    tumor protein p53 binding protein, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011625.1 → NP_035755.1  apoptosis-stimulating of p53 protein 1

      See identical proteins and their annotated locations for NP_035755.1

      Status: PROVISIONAL

      Source sequence(s)
      BC054788
      Consensus CDS
      CCDS56866.1
      UniProtKB/Swiss-Prot
      Q62415
      UniProtKB/TrEMBL
      A0A1Y7VJH3
      Related
      ENSMUSP00000062464.8, ENSMUST00000054815.15
      Conserved Domains (7) summary
      cd00204
      Location:883 → 1006
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam07321
      Location:154 → 317
      YscO; Type III secretion protein YscO
      pfam12796
      Location:889 → 975
      Ank_2; Ankyrin repeats (3 copies)
      pfam13863
      Location:153 → 247
      DUF4200; Domain of unknown function (DUF4200)
      sd00045
      Location:889 → 915
      ANK; ANK repeat [structural motif]
      cl09111
      Location:208 → 318
      Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
      cl17036
      Location:1019 → 1075
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111794892..111874549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515796.5 → XP_006515859.1  apoptosis-stimulating of p53 protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VJH3
      Conserved Domains (6) summary
      PHA03247
      Location:479 → 895
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:153 → 329
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:924 → 950
      ANK; ANK repeat [structural motif]
      cd17224
      Location:2 → 86
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:924 → 1010
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1054 → 1110
      SH3; Src Homology 3 domain superfamily

    2. XM_006515797.5 → XP_006515860.1  apoptosis-stimulating of p53 protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A1Y7VJH3
      Related
      ENSMUSP00000152424.2, ENSMUST00000220486.2
      Conserved Domains (6) summary
      PHA03247
      Location:476 → 892
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:150 → 326
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:921 → 947
      ANK; ANK repeat [structural motif]
      cd17224
      Location:1 → 83
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:921 → 1007
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1051 → 1107
      SH3; Src Homology 3 domain superfamily

    3. XM_030246683.2 → XP_030102543.1  apoptosis-stimulating of p53 protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A1Y7VJH3
      Conserved Domains (6) summary
      PHA03247
      Location:441 → 857
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:150 → 326
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00045
      Location:886 → 912
      ANK; ANK repeat [structural motif]
      cd17224
      Location:1 → 83
      RA_ASPP1; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 1 (ASPP1)
      pfam12796
      Location:886 → 972
      Ank_2; Ankyrin repeats (3 copies)
      cl17036
      Location:1016 → 1072
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62415.2 GenPept UniProtKB/Swiss-Prot:Q62415

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