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    Tnfaip1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [ Mus musculus (house mouse) ]

    Gene ID: 21927, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tnfaip1provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 1 (endothelial)provided by MGI
    Primary source
    MGI:MGI:104961
    See related
    Ensembl:ENSMUSG00000017615 AllianceGenome:MGI:104961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Edp1; Edp-1; Tnfip1; Bacurd2
    Summary
    Predicted to enable cyclin binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of Rho protein signal transduction; and stress fiber assembly. Predicted to be located in endosome. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in brain; heart valve; sensory organ; and skeleton. Orthologous to human TNFAIP1 (TNF alpha induced protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 35.5), large intestine adult (RPKM 31.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 B5; 11 46.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78413676..78427122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78522850..78536270, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 199 Neighboring gene polymerase (DNA-directed), delta interacting protein 2 Neighboring gene intraflagellar transport 20 Neighboring gene transmembrane protein 97 Neighboring gene STARR-positive B cell enhancer ABC_E3979

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells. Yi J, et al. Neurotox Res, 2020 Jun. PMID 32335808
    2. TNFAIP1 contributes to the neurotoxicity induced by Aβ25-35 in Neuro2a cells. Liu N, et al. BMC Neurosci, 2016 Jul 18. PMID 27430312, Free PMC Article
    3. Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons. Gladwyn-Ng I, et al. Neural Dev, 2016 Mar 11. PMID 26969432, Free PMC Article
    4. Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus. Liu H, et al. Int J Mol Med, 2014 Jul. PMID 24737445
    5. miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells. He D, et al. Biochem Biophys Res Commun, 2017 Aug 26. PMID 28655611

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2beta.
      Title: MiR-93 alleviates DEHP plasticizer-induced neurotoxicity by negatively regulating TNFAIP1 and inhibiting ubiquitin-mediated degradation of CK2β.
    2. Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
      Title: Knocking down TNFAIP1 alleviates inflammation and oxidative stress in pediatric pneumonia through PI3K/Akt/Nrf2 pathway.
    3. TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
      Title: TNFAIP1 Mediates Formaldehyde-Induced Neurotoxicity by Inhibiting the Akt/CREB Pathway in N2a Cells.
    4. Results demonstrated that TNFAIP1 was significantly upregulated by Abeta25-35 in mouse primary cortical neurons and N2a cells, and TNFAIP1 may be a key player that mediated Abeta25-35-induced neurotoxicity by inactivating the Akt/CREB signaling pathway, and in turn downregulating anti-apoptotic protein Bcl-2.
      Title: TNFAIP1 contributes to the neurotoxicity induced by Aβ25-35 in Neuro2a cells.
    5. ABETA 25-35 downregulated miR-137 and upregulated TNFAIP1 in cortical neurons and N2a cells.
      Title: miR-137 attenuates Aβ-induced neurotoxicity through inactivation of NF-κB pathway by targeting TNFAIP1 in Neuro2a cells.
    6. Study identifies Bacurd1/Kctd13 and Bacurd2/Tnfaip1 as interacting partners to RhoA GTPase proteins which influence the development of cortical neurons.
      Title: Bacurd1/Kctd13 and Bacurd2/Tnfaip1 are interacting partners to Rnd proteins which influence the long-term positioning and dendritic maturation of cerebral cortical neurons.
    7. Bacurd2 influences the multipolar-to-bipolar transition of radially migrating neurons in a cell autonomous fashion. Bacurd2 and Rnd2 interact to promote radial migration within the embryonic cortex.
      Title: Bacurd2 is a novel interacting partner to Rnd2 which controls radial migration within the developing mammalian cerebral cortex.
    8. Estrogen and ERbeta regulate Tnfaip1 expression in mouse hippocampus.
      Title: Estrogen is a novel regulator of Tnfaip1 in mouse hippocampus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
    Names
    BTB/POZ domain-containing protein TNFAIP1
    tumor necrosis factor induced protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159392.1 → NP_001152864.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_001152864.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK034305, AK147809, AK168805, BY060883, CB205355
      Consensus CDS
      CCDS25110.1
      UniProtKB/Swiss-Prot
      O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
      Related
      ENSMUSP00000103912.3, ENSMUST00000108277.3
      Conserved Domains (2) summary
      smart00225
      Location:29 → 127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:30 → 120
      BTB_2; BTB/POZ domain

    2. NM_009395.4 → NP_033421.3  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

      See identical proteins and their annotated locations for NP_033421.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK034305, AK147809, AK168805, BY329500, CB205355
      Consensus CDS
      CCDS25110.1
      UniProtKB/Swiss-Prot
      O70479, Q3TH85, Q3UGQ5, Q8BV61, Q8BZK5
      Related
      ENSMUSP00000017759.3, ENSMUST00000017759.9
      Conserved Domains (2) summary
      smart00225
      Location:29 → 127
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:30 → 120
      BTB_2; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      78413676..78427122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245918.2 → XP_030101778.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:1 → 25
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

    2. XM_030245919.2 → XP_030101779.1  BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 isoform X1

      Conserved Domains (1) summary
      cl38908
      Location:1 → 25
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70479.1 GenPept UniProtKB/Swiss-Prot:O70479

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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