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    Tmpo thymopoietin [ Mus musculus (house mouse) ]

    Gene ID: 21917, updated on 2-Apr-2024

    Summary

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    Official Symbol
    Tmpoprovided by MGI
    Official Full Name
    thymopoietinprovided by MGI
    Primary source
    MGI:MGI:106920
    See related
    Ensembl:ENSMUSG00000019961 AllianceGenome:MGI:106920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TP; LAP2; 5630400D24Rik
    Summary
    Enables identical protein binding activity. Acts upstream of or within regulation of transcription, DNA-templated. Located in nuclear envelope. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 41.2), limb E14.5 (RPKM 32.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmpo in Genome Data Viewer
    Location:
    10 C2; 10 45.66 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90983433..91017614, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91147571..91181752, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9131 Neighboring gene IKBKB interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E370 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene STARR-positive B cell enhancer ABC_E6900 Neighboring gene STARR-positive B cell enhancer ABC_E5165 Neighboring gene STARR-seq mESC enhancer starr_27543 Neighboring gene STARR-seq mESC enhancer starr_27545 Neighboring gene STARR-seq mESC enhancer starr_27546 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene RIKEN cDNA 4930534H03 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple novel functions of lamina associated polypeptide 2α in striated muscle. Gotic I, et al. Nucleus, 2010 Sep-Oct. PMID 21326822, Free PMC Article
    2. Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination. Gotic I, et al. Stem Cells, 2010 Mar 31. PMID 20039368
    3. Identification of phosphorylation sites in native lamina-associated polypeptide 2 beta. Dreger M, et al. Biochemistry, 1999 Jul 20. PMID 10413518
    4. Ubiquitous expression of a cloned murine thymopoietin cDNA. Theodor L, et al. Acta Haematol, 1997. PMID 9066710
    5. Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity. Sidorenko E, et al. Sci Rep, 2022 Feb 10. PMID 35145145, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased expression of LAP2beta eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
      Title: Increased expression of LAP2β eliminates nuclear membrane ruptures in nuclear lamin-deficient neurons and fibroblasts.
    2. Lamina-associated polypeptide 2alpha is required for intranuclear MRTF-A activity.
      Title: Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.
    3. Lifespan and body mass were increased in Lmna(-/-)Lap2alpha(-/-) mice compared with Lmna deficient mice.
      Title: Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α.
    4. Data indicate that a LAP2alpha-independent assembly defect of DeltaK32 lamin A/C is the cause of the pathology, whereas the LAP2alpha-linked functions of nucleoplasmic lamin A/C in the regulation of tissue progenitor cells are not affected in Lmna(DeltaK32/DeltaK32) mice.
      Title: The muscle dystrophy-causing ΔK32 lamin A/C mutant does not impair the functions of the nucleoplasmic lamin-A/C-LAP2α complex in mice.
    5. LAP2alpha serves as a transcriptional co-regulator, which controls muscle specific gene expression during muscle regeneration, muscle remodeling and stress response.
      Title: Multiple novel functions of lamina associated polypeptide 2α in striated muscle.
    6. TSLP diverts airway tolerance against ovalbumin (OVA) to T helper cell type (Th)2 sensitization and inhibits the generation of OVA-specific inducible regulatory T cells.
      Title: Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells.
    7. The age-related down-regulation of Wnt4 (and subsequently FoxN1), and the prominent increase in LAP2alpha expression, was investigated in thymic epithelial cells.
      Title: Wnt4 and LAP2alpha as pacemakers of thymic epithelial senescence.
    8. Our data demonstrate multiple and distinct functions of LAP2 alpha in muscle stem cell maintenance, early phases of myogenic differentiation, and muscle remodeling.
      Title: Loss of LAP2 alpha delays satellite cell differentiation and affects postnatal fiber-type determination.
    9. Data show that LAP2alpha knockout caused systolic dysfunction in young mice, sporadic fibrosis in old animals, and disregulation of cardiac GATA4 and MEF2c, while dstrophin deficiency in Mdx mice resulted in a transient rescue of Lap2alpha(-/-) phenotype.
      Title: Lamina-associated polypeptide 2alpha loss impairs heart function and stress response in mice.
    10. Loss of LAP2-Lmna complexes causes erythroid and epidermal progenitor hyperproliferation.
      Title: Loss of nucleoplasmic LAP2alpha-lamin A complexes causes erythroid and epidermal progenitor hyperproliferation.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lamina-associated polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080129.3 → NP_001073598.1  lamina-associated polypeptide 2 isoform epsilon

      See identical proteins and their annotated locations for NP_001073598.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains most exons of this gene and encodes isoform (epsilon).
      Source sequence(s)
      AC122188, AC140410
      Consensus CDS
      CCDS36035.1
      UniProtKB/Swiss-Prot
      Q3UCI5, Q61029, Q61030, Q61031, Q61032
      UniProtKB/TrEMBL
      Q3U7B3, Q3UR33
      Related
      ENSMUSP00000072092.8, ENSMUST00000072239.14
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    2. NM_001080130.3 → NP_001073599.1  lamina-associated polypeptide 2 isoform delta

      See identical proteins and their annotated locations for NP_001073599.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (delta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AC122188, AC140410
      Consensus CDS
      CCDS36034.1
      UniProtKB/TrEMBL
      Q3TNH0, Q3U7B3, Q3UR33
      Related
      ENSMUSP00000089864.7, ENSMUST00000092219.14
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    3. NM_001080131.3 → NP_001073600.1  lamina-associated polypeptide 2 isoform gamma

      See identical proteins and their annotated locations for NP_001073600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (gamma) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AC122188, AC140410
      Consensus CDS
      CCDS36033.1
      UniProtKB/TrEMBL
      Q3U7B3, Q3UR33
      Related
      ENSMUSP00000096956.5, ENSMUST00000099355.12
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    4. NM_001080132.3 → NP_001073601.1  lamina-associated polypeptide 2 isoform beta

      See identical proteins and their annotated locations for NP_001073601.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks three consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (beta) lacks an internal segment, compared to isoform epsilon.
      Source sequence(s)
      AC122188, AC140410
      Consensus CDS
      CCDS36032.1
      UniProtKB/Swiss-Prot
      Q61029
      Related
      ENSMUSP00000100930.4, ENSMUST00000105293.11
      Conserved Domains (2) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein

    5. NM_001283048.2 → NP_001269977.1  lamina-associated polypeptide 2 isoform omega

      See identical proteins and their annotated locations for NP_001269977.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (omega) has a much shorter N-terminus, compared to isoform epsilon. Variants 7-14 all encode the same isoform (omega).
      Source sequence(s)
      AC122188, AC140410
      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      COG1426
      Location:26 → 99
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

    6. NM_001428854.1 → NP_001415783.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    7. NM_001428855.1 → NP_001415784.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    8. NM_001428856.1 → NP_001415785.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    9. NM_001428857.1 → NP_001415786.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    10. NM_001428858.1 → NP_001415787.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    11. NM_001428859.1 → NP_001415788.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    12. NM_001428860.1 → NP_001415789.1  lamina-associated polypeptide 2 isoform omega

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    13. NM_011605.4 → NP_035735.2  lamina-associated polypeptide 2 isoform alpha

      See identical proteins and their annotated locations for NP_035735.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks several exons but has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (alpha) is longer and has a distinct C-terminus, compared to isoform epsilon.
      Source sequence(s)
      AC122188, AC140410
      Consensus CDS
      CCDS24122.1
      UniProtKB/Swiss-Prot
      B2RUB9, Q61028, Q61033
      Related
      ENSMUSP00000020123.6, ENSMUST00000020123.7
      Conserved Domains (3) summary
      cd12940
      Location:110 → 138
      LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
      pfam08198
      Location:2 → 49
      Thymopoietin; Thymopoietin protein
      pfam11560
      Location:459 → 692
      LAP2alpha; Lamina-associated polypeptide 2 alpha

    RNA

    1. NR_190513.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122188

    2. NR_190514.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    3. NR_190515.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122188, AC140410

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      90983433..91017614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245061.1 → XP_030100921.1  lamina-associated polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      COG1426
      Location:26 → 99
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

    2. XM_006513590.4 → XP_006513653.1  lamina-associated polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      Q3TXQ1
      Conserved Domains (1) summary
      COG1426
      Location:26 → 99
      RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080134.1: Suppressed sequence

      Description
      NM_001080134.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61029.4 GenPept UniProtKB/Swiss-Prot:Q61029
    Q61033.4 GenPept UniProtKB/Swiss-Prot:Q61033

    Gene LinkOut

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