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    Zmym5 zinc finger, MYM-type 5 [ Mus musculus (house mouse) ]

    Gene ID: 219105, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zmym5provided by MGI
    Official Full Name
    zinc finger, MYM-type 5provided by MGI
    Primary source
    MGI:MGI:3041170
    See related
    Ensembl:ENSMUSG00000040123 AllianceGenome:MGI:3041170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830124H08Rik
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in genitourinary system. Orthologous to human ZMYM5 (zinc finger MYM-type containing 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.9), CNS E11.5 (RPKM 6.6) and 27 other tissues See more
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    Genomic context

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    Location:
    14 C3; 14 28.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (57028042..57049213, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (56790585..56815051, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene paraspeckle protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E9897 Neighboring gene predicted gene 4479 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene RIKEN cDNA 2410022M11 gene Neighboring gene STARR-positive B cell enhancer ABC_E5443 Neighboring gene STARR-seq mESC enhancer starr_36798 Neighboring gene predicted gene, 48906

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation. Carmona-Mora P, et al. Hum Genet, 2015 Oct. PMID 26275350
    2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC38922

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger MYM-type protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253752.1 → NP_001240681.1  zinc finger MYM-type protein 5

      See identical proteins and their annotated locations for NP_001240681.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC154361
      Consensus CDS
      CCDS49505.1
      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Related
      ENSMUSP00000043625.10, ENSMUST00000039812.16
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    2. NM_001253753.1 → NP_001240682.1  zinc finger MYM-type protein 5

      See identical proteins and their annotated locations for NP_001240682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      AC154361
      Consensus CDS
      CCDS49505.1
      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Related
      ENSMUSP00000134057.2, ENSMUST00000173954.3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    3. NM_144842.4 → NP_659091.3  zinc finger MYM-type protein 5

      See identical proteins and their annotated locations for NP_659091.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), and variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC154361
      Consensus CDS
      CCDS49505.1
      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Related
      ENSMUSP00000106916.3, ENSMUST00000111285.9
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    RNA

    1. NR_136882.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154361, AK036513

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      57028042..57049213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518852.5 → XP_006518915.2  zinc finger MYM-type protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    2. XM_011245022.3 → XP_011243324.1  zinc finger MYM-type protein 5 isoform X1

      See identical proteins and their annotated locations for XP_011243324.1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    3. XM_036158560.1 → XP_036014453.1  zinc finger MYM-type protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    4. XM_030247759.2 → XP_030103619.1  zinc finger MYM-type protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    5. XM_017315967.2 → XP_017171456.1  zinc finger MYM-type protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    6. XM_006518857.3 → XP_006518920.1  zinc finger MYM-type protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006518920.1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif

    7. XM_030247761.2 → XP_030103621.1  zinc finger MYM-type protein 5 isoform X1

      UniProtKB/Swiss-Prot
      Q3U2E2, Q8R1W3
      Conserved Domains (2) summary
      smart00597
      Location:528 → 603
      ZnF_TTF; zinc finger in transposases and transcription factors
      pfam06467
      Location:343 → 381
      zf-FCS; MYM-type Zinc finger with FCS sequence motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U2E2.2 GenPept UniProtKB/Swiss-Prot:Q3U2E2

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