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    Khnyn KH and NYN domain containing [ Mus musculus (house mouse) ]

    Gene ID: 219094, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Khnynprovided by MGI
    Official Full Name
    KH and NYN domain containingprovided by MGI
    Primary source
    MGI:MGI:2451333
    See related
    Ensembl:ENSMUSG00000047153 AllianceGenome:MGI:2451333
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0323; mKIAA0323; 6330555F21; 9130227C08Rik
    Summary
    This gene encodes a protein with a C-terminal RNA modifying domain that belongs to a family of ribonucleases typified by eukaryotic Nedd4-binding protein1 and the bacterial YacP-like nucleases (NYN). The NYN domain shares a common protein fold with two other groups of nucleases, the PilT N-terminal nuclease and FLAP nuclease superfamilies. In addition to the NYN domain, the protein encoded by this gene also contains an N-terminal K homology RNA-binding domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in colon adult (RPKM 21.7), cerebellum adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C3; 14 28.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (56122269..56136237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55884812..55898780)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene NYN domain and retroviral integrase containing Neighboring gene STARR-positive B cell enhancer ABC_E7318 Neighboring gene STARR-positive B cell enhancer ABC_E7319 Neighboring gene cerebellin 3 precursor protein Neighboring gene short chain dehydrogenase/reductase family 39U, member 1 Neighboring gene STARR-seq mESC enhancer starr_36786 Neighboring gene chymase 1, mast cell Neighboring gene mast cell protease, pseudogene 1 Neighboring gene chymase 2, mast cell

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. The NYN domains: novel predicted RNAses with a PIN domain-like fold. Anantharaman V, et al. RNA Biol, 2006 Jan-Mar. PMID 17114934
    4. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein KHNYN
    Names
    KH and NYN domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027143.3 → NP_081419.1  protein KHNYN

      See identical proteins and their annotated locations for NP_081419.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC098877, AK122247, BP757894
      Consensus CDS
      CCDS27134.1
      UniProtKB/Swiss-Prot
      Q14B94, Q80U38, Q8BGJ6, Q8C082
      UniProtKB/TrEMBL
      A0A2I3BPI4
      Related
      ENSMUSP00000022831.4, ENSMUST00000022831.5
      Conserved Domains (1) summary
      pfam11977
      Location:429 → 582
      RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain

    RNA

    1. NR_138134.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC098877, BP757894
      Related
      ENSMUST00000228462.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      56122269..56136237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003950841.1 RNA Sequence

    2. XR_383164.4 RNA Sequence

    3. XR_004938384.1 RNA Sequence

    4. XR_004938383.1 RNA Sequence

    5. XR_383165.3 RNA Sequence

    6. XR_004938382.1 RNA Sequence

    7. XR_383166.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80U38.2 GenPept UniProtKB/Swiss-Prot:Q80U38

    Gene LinkOut

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