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    Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 219024, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pip4p1provided by MGI
    Official Full Name
    phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1provided by MGI
    Primary source
    MGI:MGI:2448501
    See related
    Ensembl:ENSMUSG00000035953 AllianceGenome:MGI:2448501
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem55b
    Summary
    Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in positive regulation of TORC1 signaling and proton-transporting V-type ATPase complex assembly. Located in bounding membrane of organelle and plasma membrane. Orthologous to human PIP4P1 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 44.4), mammary gland adult (RPKM 32.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C1; 14 26.3 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51164672..51168306, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50927215..50931010, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene Apex1 promoter region Neighboring gene apurinic/apyrimidinic endonuclease 1 Neighboring gene STARR-seq mESC enhancer starr_36659 Neighboring gene STARR-positive B cell enhancer ABC_E7308 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase Neighboring gene predicted gene, 38316 Neighboring gene purine-nucleoside phosphorylase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. Takemasu S, et al. J Biochem, 2019 Aug 1. PMID 31329883
    2. Phosphatidylinositol-(4,5)-Bisphosphate Regulates Plasma Cholesterol Through LDL (Low-Density Lipoprotein) Receptor Lysosomal Degradation. Qin Y, et al. Arterioscler Thromb Vasc Biol, 2020 May. PMID 32188273, Free PMC Article
    3. TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. Morioka S, et al. J Cell Sci, 2018 Mar 6. PMID 29378918
    4. The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Ungewickell A, et al. Proc Natl Acad Sci U S A, 2005 Dec 27. PMID 16365287, Free PMC Article
    5. TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation. Hashimoto Y, et al. Genes Cells, 2018 Jun. PMID 29644770

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118137

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton-transporting V-type ATPase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sterol depletion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagocytic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    Names
    PtdIns-4,5-P(2) 4-phosphatase type I
    ptdIns-4,5-P2 4-Ptase I
    transmembrane protein 55b
    type 1 PtdIns-4,5-P2 4-Ptase
    type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase
    NP_001028443.1
    NP_001297434.1
    NP_001297435.1
    NP_001297436.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033271.5 → NP_001028443.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001028443.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK144251, BE943635
      Consensus CDS
      CCDS27028.1
      UniProtKB/Swiss-Prot
      Q3TWL2
      Related
      ENSMUSP00000124782.2, ENSMUST00000160835.9
      Conserved Domains (1) summary
      pfam09788
      Location:4 → 277
      Tmemb_55A; Transmembrane protein 55A

    2. NM_001310505.1 → NP_001297434.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK144251, BE943635, BY071053
      Consensus CDS
      CCDS79324.1
      UniProtKB/TrEMBL
      F8WHW3
      Related
      ENSMUSP00000038276.8, ENSMUST00000049312.14
      Conserved Domains (1) summary
      pfam09788
      Location:4 → 270
      Tmemb_55A; Transmembrane protein 55A

    3. NM_001310506.1 → NP_001297435.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
      Source sequence(s)
      AK144251, BE943635
      Consensus CDS
      CCDS79322.1
      UniProtKB/TrEMBL
      E0CZ18
      Related
      ENSMUSP00000123697.2, ENSMUST00000162957.8
      Conserved Domains (1) summary
      pfam09788
      Location:4 → 154
      Tmemb_55A; Transmembrane protein 55A

    4. NM_001310507.1 → NP_001297436.1  type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate exon in the central coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct central region and C-terminus compared to isoform 1.
      Source sequence(s)
      AK144251, BE943635, CX240137
      Consensus CDS
      CCDS79323.1
      UniProtKB/TrEMBL
      E0CZF6
      Related
      ENSMUSP00000125414.2, ENSMUST00000161166.8
      Conserved Domains (1) summary
      pfam09788
      Location:4 → 147
      Tmemb_55A; Transmembrane protein 55A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51164672..51168306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TWL2.1 GenPept UniProtKB/Swiss-Prot:Q3TWL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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