Tle3 transducin-like enhancer of split 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tle3provided by MGI
Official Full Name: transducin-like enhancer of split 3provided by MGI
Primary source: MGI:MGI:104634
See related: Ensembl:ENSMUSG00000032280 AllianceGenome:MGI:104634
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ESG; Grg3a; Grg3b; mKIAA1547; 2610103N05Rik
Summary: Predicted to enable transcription corepressor activity. Involved in negative regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 52.0), thymus adult (RPKM 46.3) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 33.27 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (61279608..61325779)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (61372326..61418497)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Title: The Wnt-pathway corepressor TLE3 interacts with the histone methyltransferase KMT1A to inhibit differentiation in Rhabdomyosarcoma.
Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation.
Title: Zeb1 and Tle3 are trans-factors that differentially regulate the expression of myosin heavy chain-embryonic and skeletal muscle differentiation.
TLE3 and TLE4-coordinated colonic macrophage-CD4[+] T cell crosstalk maintains intestinal immune homeostasis.
Title: TLE3 and TLE4-coordinated colonic macrophage-CD4(+) T cell crosstalk maintains intestinal immune homeostasis.
Groucho co-repressor proteins regulate beta cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.
Title: Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.
Title: The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.
TLE3 regulates thermogenic gene expression in beige adipocytes through inhibition of EBF2 transcriptional activity
Title: Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism.
These findings indicate that Tle corepressors are differentially partitioned to Runx and Tcf/Lef complexes to instruct CD8(+) lineage choice and cooperatively establish CD8(+) T cell identity, respectively.
Title: Tle corepressors are differentially partitioned to instruct CD8(+) T cell lineage choice and identity.
Data suggest Tle3 plays role in regulation of MyoD1 function during myogenesis; up-regulation of Tle3 expression suppresses myogenesis; conversely, down-regulation of Tle3 expression promotes myogenesis/cell proliferation; Tle3 interferes with MyoD1 by disrupting association of basic helix-loop-helix domain of MyoD with E proteins. (Tle3 = transducin-like enhancer of split 3; MyoD1 = myogenic differentiation protein 1)
Title: The transcriptional co-repressor TLE3 regulates myogenic differentiation by repressing the activity of the MyoD transcription factor.
Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression
Title: Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.
TLE3/4 activity is essential for early differentiation where it acts to suppress the pluripotency network, allowing for the initiation of lineage specific gene expression programs
Title: Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tle3 (e-PCR), detects polymorphism
- UniSTS:507281

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transducin-like enhancer protein 3

Names: grg-3; transducin-like enhancer of split 3, homolog of Drosophila E(spl)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083927.1 → NP_001077396.1 transducin-like enhancer protein 3 isoform 1

See identical proteins and their annotated locations for NP_001077396.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AC126672, BB611599, BC056465, BX630781

Consensus CDS

CCDS52826.1

UniProtKB/TrEMBL

J3KMT7

Related

ENSMUSP00000124131.2, ENSMUST00000160882.8

Conserved Domains (4) summary

cd00200
Location:494 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 482

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:499 → 538

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_001083928.1 → NP_001077397.1 transducin-like enhancer protein 3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC126672, AK122524, BB611599, BQ770333, BX630781

Consensus CDS

CCDS52824.1

UniProtKB/TrEMBL

E0CXS2, F8WIE2

Related

ENSMUSP00000034820.10, ENSMUST00000034820.16

Conserved Domains (4) summary

cd00200
Location:476 → 761

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 464

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:481 → 520

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
NM_009389.2 → NP_033415.2 transducin-like enhancer protein 3 isoform 2

See identical proteins and their annotated locations for NP_033415.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC126672, AK031322, AK122524, BB611599, BQ770333, BX630781

Consensus CDS

CCDS52825.1

UniProtKB/Swiss-Prot

Q08122, Q6PHP0, Q923A4

UniProtKB/TrEMBL

J3KMT7

Related

ENSMUSP00000124173.2, ENSMUST00000162973.8

Conserved Domains (4) summary

cd00200
Location:484 → 769

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 472

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:489 → 528

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

61279608..61325779

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511026.4 → XP_006511089.1 transducin-like enhancer protein 3 isoform X4

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:489 → 774

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 477

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:494 → 533

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511025.4 → XP_006511088.1 transducin-like enhancer protein 3 isoform X2

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:491 → 776

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 479

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:496 → 535

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511027.4 → XP_006511090.1 transducin-like enhancer protein 3 isoform X5

UniProtKB/TrEMBL

J3KMT7

Related

ENSMUSP00000124150.2, ENSMUST00000162127.2

Conserved Domains (4) summary

cd00200
Location:486 → 771

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:261 → 474

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:491 → 530

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 143

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017313277.2 → XP_017168766.1 transducin-like enhancer protein 3 isoform X1

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:493 → 778

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:260 → 481

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:498 → 537

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_036154839.1 → XP_036010732.1 transducin-like enhancer protein 3 isoform X3

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:490 → 775

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:260 → 478

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:495 → 534

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 142

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511029.4 → XP_006511092.1 transducin-like enhancer protein 3 isoform X9

UniProtKB/TrEMBL

E0CXS9, J3KMT7

Related

ENSMUSP00000125032.2, ENSMUST00000159050.8

Conserved Domains (4) summary

cd00200
Location:479 → 764

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 467

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:484 → 523

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511028.4 → XP_006511091.1 transducin-like enhancer protein 3 isoform X7

UniProtKB/TrEMBL

E0CXS2

Related

ENSMUSP00000124977.2, ENSMUST00000162583.8

Conserved Domains (4) summary

cd00200
Location:481 → 766

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:251 → 469

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:486 → 525

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 133

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017313278.2 → XP_017168767.1 transducin-like enhancer protein 3 isoform X6

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:483 → 768

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:250 → 471

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:488 → 527

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511030.4 → XP_006511093.1 transducin-like enhancer protein 3 isoform X10

UniProtKB/TrEMBL

J3KMT7

Conserved Domains (4) summary

cd00200
Location:478 → 763

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:250 → 466

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:483 → 522

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_017313279.2 → XP_017168768.1 transducin-like enhancer protein 3 isoform X8

UniProtKB/TrEMBL

E0CXS2

Related

ENSMUSP00000123723.2, ENSMUST00000159630.8

Conserved Domains (4) summary

cd00200
Location:480 → 765

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:250 → 468

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:485 → 524

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain
XM_006511031.4 → XP_006511094.1 transducin-like enhancer protein 3 isoform X11

UniProtKB/TrEMBL

E0CXS2

Conserved Domains (4) summary

cd00200
Location:475 → 760

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam05109
Location:250 → 463

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

sd00039
Location:480 → 519

7WD40; WD40 repeat [structural motif]

pfam03920
Location:9 → 132

TLE_N; Groucho/TLE N-terminal Q-rich domain