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    Tle2 transducin-like enhancer of split 2 [ Mus musculus (house mouse) ]

    Gene ID: 21886, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tle2provided by MGI
    Official Full Name
    transducin-like enhancer of split 2provided by MGI
    Primary source
    MGI:MGI:104635
    See related
    Ensembl:ENSMUSG00000034771 AllianceGenome:MGI:104635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grg2; Gm32024; mKIAA4188
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and negative regulation of transcription, DNA-templated. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in focal adhesion and nuclear body. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; integumental system; limb; and sensory organ. Orthologous to human TLE2 (TLE family member 2, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal adult (RPKM 114.6), ovary adult (RPKM 111.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10; 10 C1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81410573..81435018)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81574739..81592581)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TLE family member 5, transcriptional modulator Neighboring gene STARR-positive B cell enhancer ABC_E3902 Neighboring gene predicted gene, 31936 Neighboring gene transducin-like enhancer of split 6 Neighboring gene STARR-positive B cell enhancer ABC_E9796 Neighboring gene STARR-positive B cell enhancer ABC_E2953 Neighboring gene STARR-positive B cell enhancer ABC_E464 Neighboring gene zinc finger protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_27345 Neighboring gene STARR-positive B cell enhancer ABC_E6888 Neighboring gene sirtuin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The E2A-HLF oncoprotein activates Groucho-related genes and suppresses Runx1. Dang J, et al. Mol Cell Biol, 2001 Sep. PMID 11486032, Free PMC Article
    2. TLE expression correlates with mouse embryonic segmentation, neurogenesis, and epithelial determination. Dehni G, et al. Mech Dev, 1995 Nov. PMID 8645603
    3. Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. Grbavec D, et al. Eur J Biochem, 1998 Dec 1. PMID 9874198
    4. Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Mallo M, et al. Dev Dyn, 1995 Nov. PMID 8573724
    5. A Gro/TLE-NuRD corepressor complex facilitates Tbx20-dependent transcriptional repression. Kaltenbrun E, et al. J Proteome Res, 2013 Dec 6. PMID 24024827, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4188

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 2
    Names
    groucho-related protein
    transducin-like enhancer of split 2, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252401.2 → NP_001239330.1  transducin-like enhancer protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001239330.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses different splice sites in two locations in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC153919, AC159474
      Consensus CDS
      CCDS56737.1
      UniProtKB/TrEMBL
      E9PV07, Q3UN01
      Related
      ENSMUSP00000117453.2, ENSMUST00000135211.8
      Conserved Domains (4) summary
      COG2319
      Location:444 → 730
      WD40; WD40 repeat [General function prediction only]
      pfam03920
      Location:1 → 113
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:449 → 488
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:445 → 729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001428852.1 → NP_001415781.1  transducin-like enhancer protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153919, AC159474

    3. NM_001428853.1 → NP_001415782.1  transducin-like enhancer protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153919, AC159474

    4. NM_019725.3 → NP_062699.1  transducin-like enhancer protein 2 isoform 1

      See identical proteins and their annotated locations for NP_062699.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC153919, AC159474
      Consensus CDS
      CCDS24063.1
      UniProtKB/Swiss-Prot
      Q9WVB2
      UniProtKB/TrEMBL
      E9PV07
      Related
      ENSMUSP00000121125.2, ENSMUST00000146358.8
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:480 → 764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81410573..81435018
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243429.3 → XP_011241731.1  transducin-like enhancer protein 2 isoform X5

      See identical proteins and their annotated locations for XP_011241731.1

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:466 → 723
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011243434.3 → XP_011241736.1  transducin-like enhancer protein 2 isoform X8

      See identical proteins and their annotated locations for XP_011241736.1

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 436
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:461 → 500
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:443 → 700
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_036155761.1 → XP_036011654.1  transducin-like enhancer protein 2 isoform X13

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 423
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:448 → 487
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:430 → 687
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_017313923.3 → XP_017169412.1  transducin-like enhancer protein 2 isoform X27

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:473 → 641
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_011243425.4 → XP_011241727.1  transducin-like enhancer protein 2 isoform X1

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:465 → 722
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_011243427.4 → XP_011241729.1  transducin-like enhancer protein 2 isoform X3

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 447
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:472 → 511
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:454 → 711
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_011243428.4 → XP_011241730.1  transducin-like enhancer protein 2 isoform X4

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 446
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:471 → 510
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:453 → 710
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_011243426.4 → XP_011241728.1  transducin-like enhancer protein 2 isoform X2

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:268 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 151
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:465 → 722
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_011243430.4 → XP_011241732.1  transducin-like enhancer protein 2 isoform X6

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:248 → 438
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:463 → 502
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 131
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:445 → 702
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_011243431.4 → XP_011241733.1  transducin-like enhancer protein 2 isoform X7

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:247 → 437
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:462 → 501
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 130
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:444 → 701
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_036155764.1 → XP_036011657.1  transducin-like enhancer protein 2 isoform X31

      Conserved Domains (2) summary
      sd00039
      Location:81 → 120
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:70 → 320
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_030245058.2 → XP_030100918.1  transducin-like enhancer protein 2 isoform X32

      Conserved Domains (2) summary
      sd00039
      Location:67 → 106
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:56 → 306
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    13. XM_011243432.4 → XP_011241734.1  transducin-like enhancer protein 2 isoform X8

      See identical proteins and their annotated locations for XP_011241734.1

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 436
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:461 → 500
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:443 → 700
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_030245051.2 → XP_030100911.1  transducin-like enhancer protein 2 isoform X9

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 435
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:460 → 499
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:442 → 699
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    15. XM_030245052.2 → XP_030100912.1  transducin-like enhancer protein 2 isoform X12

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 424
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:449 → 488
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:431 → 688
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    16. XM_011243433.4 → XP_011241735.1  transducin-like enhancer protein 2 isoform X13

      UniProtKB/TrEMBL
      E9PV07
      Related
      ENSMUSP00000121173.2, ENSMUST00000146916.8
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 423
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:448 → 487
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:430 → 687
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    17. XM_017313919.3 → XP_017169408.1  transducin-like enhancer protein 2 isoform X10

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 435
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:460 → 499
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:442 → 699
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    18. XM_017313920.3 → XP_017169409.1  transducin-like enhancer protein 2 isoform X11

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 434
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:459 → 498
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:441 → 698
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    19. XM_017313921.3 → XP_017169410.1  transducin-like enhancer protein 2 isoform X14

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 422
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:447 → 486
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:429 → 686
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    20. XM_036155763.1 → XP_036011656.1  transducin-like enhancer protein 2 isoform X30

      Conserved Domains (2) summary
      sd00039
      Location:93 → 132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:82 → 332
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    21. XM_011243435.4 → XP_011241737.1  transducin-like enhancer protein 2 isoform X15

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:225 → 415
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:440 → 479
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 108
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:422 → 679
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    22. XM_006513584.4 → XP_006513647.1  transducin-like enhancer protein 2 isoform X16

      See identical proteins and their annotated locations for XP_006513647.1

      UniProtKB/Swiss-Prot
      Q9WVB2
      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:480 → 764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    23. XM_006513585.4 → XP_006513648.1  transducin-like enhancer protein 2 isoform X17

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 458
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:483 → 522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:479 → 763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    24. XM_030245053.2 → XP_030100913.1  transducin-like enhancer protein 2 isoform X18

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 447
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:472 → 511
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:468 → 752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    25. XM_017313922.3 → XP_017169411.1  transducin-like enhancer protein 2 isoform X19

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 446
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:471 → 510
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:467 → 751
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    26. XM_030245059.2 → XP_030100919.1  transducin-like enhancer protein 2 isoform X33

      UniProtKB/TrEMBL
      Q5DTI7
      Related
      ENSMUST00000140433.8
      Conserved Domains (2) summary
      sd00039
      Location:93 → 132
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:89 → 373
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    27. XM_006513589.5 → XP_006513652.1  transducin-like enhancer protein 2 isoform X34

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 435
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:460 → 499
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:456 → 740
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    28. XM_030245055.2 → XP_030100915.1  transducin-like enhancer protein 2 isoform X22

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 424
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:449 → 488
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:445 → 729
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    29. XM_030245056.2 → XP_030100916.1  transducin-like enhancer protein 2 isoform X23

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:246 → 423
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:448 → 487
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 129
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:444 → 728
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    30. XM_011243436.4 → XP_011241738.1  transducin-like enhancer protein 2 isoform X21

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 434
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:459 → 498
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:455 → 739
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    31. XM_030245057.2 → XP_030100917.1  transducin-like enhancer protein 2 isoform X24

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 422
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:447 → 486
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:443 → 727
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    32. XM_030245060.2 → XP_030100920.1  transducin-like enhancer protein 2 isoform X35

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:225 → 414
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:439 → 478
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 108
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:435 → 719
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    33. XM_006513586.4 → XP_006513649.1  transducin-like enhancer protein 2 isoform X25

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:484 → 523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:466 → 711
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    34. XM_036155762.1 → XP_036011655.1  transducin-like enhancer protein 2 isoform X26

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:269 → 446
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:471 → 510
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:10 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:453 → 698
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    35. XM_006513588.5 → XP_006513651.1  transducin-like enhancer protein 2 isoform X28

      Conserved Domains (3) summary
      smart00320
      Location:473 → 508
      WD40; WD40 repeats
      PHA03247
      Location:269 → 460
      PHA03247; large tegument protein UL36; Provisional
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    36. XM_017313924.3 → XP_017169413.1  transducin-like enhancer protein 2 isoform X29

      Conserved Domains (3) summary
      smart00320
      Location:472 → 507
      WD40; WD40 repeats
      PHA03247
      Location:269 → 459
      PHA03247; large tegument protein UL36; Provisional
      pfam03920
      Location:1 → 152
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    37. XM_030245054.2 → XP_030100914.1  transducin-like enhancer protein 2 isoform X20

      UniProtKB/TrEMBL
      E9PV07
      Conserved Domains (4) summary
      PHA03247
      Location:193 → 383
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:408 → 447
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:24 → 76
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      cl29593
      Location:390 → 647
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004936169.1 RNA Sequence

    2. XR_380389.5 RNA Sequence

    3. XR_003948682.2 RNA Sequence

    4. XR_004936170.1 RNA Sequence

    5. XR_380390.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVB2.1 GenPept UniProtKB/Swiss-Prot:Q9WVB2

    Gene LinkOut

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