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    Tasor transcription activation suppressor [ Mus musculus (house mouse) ]

    Gene ID: 218850, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Tasorprovided by MGI
    Official Full Name
    transcription activation suppressorprovided by MGI
    Primary source
    MGI:MGI:1921694
    See related
    Ensembl:ENSMUSG00000040651 AllianceGenome:MGI:1921694
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam208a; MommeD6; D14Abb1e; 4732418E12; 4933409E02Rik
    Summary
    Predicted to enable chromatin binding activity. Involved in anterior/posterior axis specification, embryo and mesodermal to mesenchymal transition involved in gastrulation. Acts upstream of or within in utero embryonic development and mitotic spindle assembly. Predicted to be located in chromosome and nucleus. Predicted to be active in heterochromatin and nucleoplasm. Is expressed in several structures, including brain; ovary stratum granulosum; and seminiferous tubule. Orthologous to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.4), CNS E18 (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 16.51 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (27150759..27205512)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (27423674..27483555)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene STARR-seq mESC enhancer starr_36271 Neighboring gene STARR-positive B cell enhancer ABC_E1891 Neighboring gene predicted gene, 52096 Neighboring gene predicted gene, 34702 Neighboring gene STARR-seq mESC enhancer starr_36272 Neighboring gene STARR-seq mESC enhancer starr_36273 Neighboring gene STARR-positive B cell enhancer ABC_E8897 Neighboring gene STARR-seq mESC enhancer starr_36274 Neighboring gene coiled-coil domain containing 66 Neighboring gene STARR-seq mESC enhancer starr_36275 Neighboring gene predicted gene, 25697 Neighboring gene predicted gene 7604

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development. Harten SK, et al. Mamm Genome, 2014 Aug. PMID 24781204, Free PMC Article
    2. A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Ashe A, et al. Genome Biol, 2008. PMID 19099580, Free PMC Article
    3. An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Blewitt ME, et al. Proc Natl Acad Sci U S A, 2005 May 24. PMID 15890782, Free PMC Article
    4. Dual role of Fam208a during zygotic cleavage and early embryonic development. Gresakova V, et al. Exp Cell Res, 2021 Sep 15. PMID 34216590
    5. The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Bhargava S, et al. Sci Rep, 2017 Aug 24. PMID 28839193, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mesodermal to mesenchymal transition involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein TASOR
    Names
    family with sequence similarity 208, member A
    protein FAM208A
    retinoblastoma-associated protein 140
    transgene activation suppressor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114879.3 → NP_001108351.1  protein TASOR isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154327, CT485787
      UniProtKB/Swiss-Prot
      E9PUH2, Q69ZR9, Q9CUD3
      Conserved Domains (1) summary
      pfam12509
      Location:153 → 314
      DUF3715; Protein of unknown function (DUF3715)

    2. NM_001404930.1 → NP_001391859.1  protein TASOR isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154327, CT485787

    3. NM_028945.3 → NP_083221.1  protein TASOR isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154327, CT485787
      Consensus CDS
      CCDS49432.1
      UniProtKB/Swiss-Prot
      E9PUH2, Q69ZR9, Q9CUD3
      Related
      ENSMUSP00000022450.5, ENSMUST00000022450.6
      Conserved Domains (1) summary
      pfam12509
      Location:153 → 314
      DUF3715; Protein of unknown function (DUF3715)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      27150759..27205512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518820.5 → XP_006518883.1  protein TASOR isoform X1

      UniProtKB/Swiss-Prot
      E9PUH2, Q69ZR9, Q9CUD3
      Conserved Domains (1) summary
      pfam12509
      Location:161 → 314
      DUF3715; Protein of unknown function (DUF3715)

    RNA

    1. XR_383159.5 RNA Sequence

    2. XR_383158.5 RNA Sequence

    3. XR_004938380.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69ZR9.2 GenPept UniProtKB/Swiss-Prot:Q69ZR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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