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    Polr3a polymerase (RNA) III (DNA directed) polypeptide A [ Mus musculus (house mouse) ]

    Gene ID: 218832, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Polr3aprovided by MGI
    Official Full Name
    polymerase (RNA) III (DNA directed) polypeptide Aprovided by MGI
    Primary source
    MGI:MGI:2681836
    See related
    Ensembl:ENSMUSG00000025280 AllianceGenome:MGI:2681836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RPC1; RPC155; 9330175N20Rik
    Summary
    Enables chromatin binding activity. Predicted to be involved in innate immune response and positive regulation of interferon-beta production. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 7 with or without oligodontia and-or hypogonadotropic hypogonadism and progeria. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.4), cerebellum adult (RPKM 4.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 14.4 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (24498762..24537126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (24448694..24487070, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36194 Neighboring gene predicted gene, 41109 Neighboring gene predicted gene, 52167 Neighboring gene predicted gene, 47814 Neighboring gene STARR-seq mESC enhancer starr_36195 Neighboring gene ribosomal protein S24 Neighboring gene predicted gene, 31720

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. Choquet K, et al. Mol Brain, 2019 Jun 20. PMID 31221184, Free PMC Article
    2. Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Choquet K, et al. Mol Brain, 2017 Apr 13. PMID 28407788, Free PMC Article
    3. A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Canella D, et al. Genome Res, 2012 Apr. PMID 22287103, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC62420

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-directed 5'-3' RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA/RNA hybrid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit RPC1
    NP_001074716.1
    XP_036014446.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081247.2 → NP_001074716.1  DNA-directed RNA polymerase III subunit RPC1

      See identical proteins and their annotated locations for NP_001074716.1

      Status: VALIDATED

      Source sequence(s)
      AC154573
      Consensus CDS
      CCDS36828.1
      UniProtKB/TrEMBL
      B2RXC6
      Related
      ENSMUSP00000026322.8, ENSMUST00000026322.9
      Conserved Domains (4) summary
      cd02736
      Location:1021 → 1360
      RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
      PRK08566
      Location:7 → 932
      PRK08566; DNA-directed RNA polymerase subunit A'; Validated
      cd02583
      Location:24 → 891
      RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain
      pfam04998
      Location:841 → 1317
      RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      24498762..24537126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158553.1 → XP_036014446.1  DNA-directed RNA polymerase III subunit RPC1 isoform X1

      Conserved Domains (3) summary
      cd02736
      Location:376 → 715
      RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
      CHL00117
      Location:196 → 413
      rpoC2; RNA polymerase beta'' subunit; Reviewed
      cl19114
      Location:1 → 246
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_183157.1: Suppressed sequence

      Description
      NM_183157.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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