Sec24c SEC24 homolog C, COPII coat complex component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec24cprovided by MGI
Official Full Name: SEC24 homolog C, COPII coat complex componentprovided by MGI
Primary source: MGI:MGI:1919746
See related: Ensembl:ENSMUSG00000039367 AllianceGenome:MGI:1919746
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0079; 2610204K03Rik
Summary: Predicted to enable SNARE binding activity and zinc ion binding activity. Acts upstream of or within in utero embryonic development. Predicted to be located in cytosol. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Is expressed in embryo and future spinal cord. Orthologous to human SEC24C (SEC24 homolog C, COPII coat complex component). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 52.7), large intestine adult (RPKM 44.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 11.53 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20722709..20744920)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20674285..20694852)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Murine SEC24D can substitute functionally for SEC24C during embryonic development.
Title: Murine SEC24D can substitute functionally for SEC24C during embryonic development.
These data suggest that SEC24C is a major cargo adapter for COPII-dependent transport in postmitotic neurons in developing and adult brains and that its functions overlap at least partially with those of SEC24D in mammals.
Title: The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
Thus, SEC24C is required in early mammalian development but is dispensable in a number of tissues, likely as a result of compensation by other Sec24 paralogs.
Title: Mammalian COPII coat component SEC24C is required for embryonic development in mice.
The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C
Title: The serotonin transporter is an exclusive client of the coat protein complex II (COPII) component SEC24C.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII-coated vesicle cargo loading	IBA Inferred from Biological aspect of Ancestor more info
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of COPII vesicle coat	IBA Inferred from Biological aspect of Ancestor more info
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein transport protein Sec24C

Names: Sec24 related gene family, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168273.1 → NP_001161745.1 protein transport protein Sec24C isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment and contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK036519, AK122199

Consensus CDS

CCDS88586.1

UniProtKB/TrEMBL

A0A286YDI8, Q80U83

Related

ENSMUSP00000153434.2, ENSMUST00000223751.2

Conserved Domains (7) summary

COG5028
Location:80 → 1016

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

cd01479
Location:425 → 684

Sec24-like; Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...

pfam00626
Location:890 → 962

Gelsolin; Gelsolin repeat

pfam04810
Location:348 → 385

zf-Sec23_Sec24; Sec23/Sec24 zinc finger

pfam04815
Location:773 → 869

Sec23_helical; Sec23/Sec24 helical domain

pfam08033
Location:674 → 757

Sec23_BS; Sec23/Sec24 beta-sandwich domain

pfam12764
Location:11 → 105

Gly-rich_Ago1; Glycine-rich region of argonaut
NM_172596.2 → NP_766184.2 protein transport protein Sec24C isoform 1

See identical proteins and their annotated locations for NP_766184.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK036519, AK122199

Consensus CDS

CCDS26850.1

UniProtKB/TrEMBL

G3X972, Q8CGF4

Related

ENSMUSP00000045955.9, ENSMUST00000048657.10

Conserved Domains (2) summary

PHA03377
Location:21 → 224

PHA03377; EBNA-3C; Provisional

COG5028
Location:181 → 1092

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

20722709..20744920

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518813.2 → XP_006518876.1 protein transport protein Sec24C isoform X1

See identical proteins and their annotated locations for XP_006518876.1

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1117

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_006518817.2 → XP_006518880.1 protein transport protein Sec24C isoform X2

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1115

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_036158551.1 → XP_036014444.1 protein transport protein Sec24C isoform X2

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1115

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_030247745.2 → XP_030103605.1 protein transport protein Sec24C isoform X4

UniProtKB/TrEMBL

G3X972, Q8CGF4

Conserved Domains (2) summary

PHA03377
Location:21 → 224

PHA03377; EBNA-3C; Provisional

COG5028
Location:181 → 1092

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]
XM_006518816.3 → XP_006518879.1 protein transport protein Sec24C isoform X1

See identical proteins and their annotated locations for XP_006518879.1

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1117

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_006518815.3 → XP_006518878.1 protein transport protein Sec24C isoform X1

See identical proteins and their annotated locations for XP_006518878.1

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1117

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_030247743.2 → XP_030103603.1 protein transport protein Sec24C isoform X3

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1094

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_036158550.1 → XP_036014443.1 protein transport protein Sec24C isoform X1

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1117

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_036158552.1 → XP_036014445.1 protein transport protein Sec24C isoform X3

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1094

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_006518818.3 → XP_006518881.1 protein transport protein Sec24C isoform X3

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1094

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein
XM_030247744.2 → XP_030103604.1 protein transport protein Sec24C isoform X3

UniProtKB/TrEMBL

Q8CGF4

Conserved Domains (2) summary

COG5028
Location:181 → 1094

COG5028; Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]

pfam15449
Location:12 → 235

Retinal; Retinal protein