Sgtb small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sgtbprovided by MGI
Official Full Name: small glutamine-rich tetratricopeptide repeat (TPR)-containing, betaprovided by MGI
Primary source: MGI:MGI:2444615
See related: Ensembl:ENSMUSG00000042743 AllianceGenome:MGI:2444615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C630001O05Rik
Summary: Predicted to enable molecular adaptor activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in posttranslational protein targeting to endoplasmic reticulum membrane and ubiquitin-dependent ERAD pathway. Predicted to be part of TRC complex. Predicted to be active in membrane. Is expressed in nervous system and sensory organ. Orthologous to human SGTB (small glutamine rich tetratricopeptide repeat co-chaperone beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 25.8), frontal lobe adult (RPKM 19.3) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 56.23 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (104246233..104278369)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (104109723..104141861)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that SGTb interacts with BOC (brother of CDO protein) and regulates its surface level and consequent JNK activation, thereby promoting neuronal differentiation and neurite outgrowth.
Title: SGTb regulates a surface localization of a guidance receptor BOC to promote neurite outgrowth.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein heterooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TRC complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: small glutamine-rich tetratricopeptide repeat-containing protein beta

Names: beta-SGT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361054.1 → NP_001347983.1 small glutamine-rich tetratricopeptide repeat-containing protein beta

Status: VALIDATED

Source sequence(s)

AC154216

Consensus CDS

CCDS26746.1

UniProtKB/Swiss-Prot

Q8VD33

Conserved Domains (3) summary

sd00006
Location:85 → 113

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerisation domain of SGTA

cl26005
Location:85 → 237

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
NM_144838.2 → NP_659087.1 small glutamine-rich tetratricopeptide repeat-containing protein beta

See identical proteins and their annotated locations for NP_659087.1

Status: VALIDATED

Source sequence(s)

AC154216, BC017611

Consensus CDS

CCDS26746.1

UniProtKB/Swiss-Prot

Q8VD33

Related

ENSMUSP00000041307.8, ENSMUST00000044385.14

Conserved Domains (3) summary

sd00006
Location:85 → 113

TPR; TPR repeat [structural motif]

pfam16546
Location:5 → 64

SGTA_dimer; Homodimerisation domain of SGTA

cl26005
Location:85 → 237

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional