Klf10 Kruppel-like transcription factor 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf10provided by MGI
Official Full Name: Kruppel-like transcription factor 10provided by MGI
Primary source: MGI:MGI:1101353
See related: Ensembl:ENSMUSG00000037465 AllianceGenome:MGI:1101353
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tieg; mGIF; Egral; Tieg1; EGR[a]; Gdnfif; TIEG-1
Summary: Enables core promoter sequence-specific DNA binding activity. Involved in cellular response to starvation and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including bone mineralization; positive regulation of osteoclast differentiation; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; humerus; and trunk unsegmented mesenchyme. Orthologous to human KLF10 (Kruppel like factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 10.6), mammary gland adult (RPKM 9.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 15.15 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (38291702..38300950, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (38291464..38300711, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLF10/CBS increases the sensitivity of gastric carcinoma cells to methionine restriction by promoting sulfur transfer pathway.
Title: KLF10/CBS increases the sensitivity of gastric carcinoma cells to methionine restriction by promoting sulfur transfer pathway.
Klf10 is involved in extracellular matrix calcification of chondrocytes alleviating chondrocyte senescence.
Title: Klf10 is involved in extracellular matrix calcification of chondrocytes alleviating chondrocyte senescence.
Multiscale analysis of Klf10's impact on the passive mechanical properties of murine skeletal muscle.
Title: Multiscale analysis of Klf10's impact on the passive mechanical properties of murine skeletal muscle.
Loss of Kruppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice.
Title: Loss of Krüppel-like factor-10 facilitates the development of chemical-induced liver cancer in mice.
KLF10 Inhibits TGF-beta-Mediated Activation of Hepatic Stellate Cells via Suppression of ATF3 Expression.
Title: KLF10 Inhibits TGF-β-Mediated Activation of Hepatic Stellate Cells via Suppression of ATF3 Expression.
A TGF-beta/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
Title: A TGF-β/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
Kruppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
Title: Krüppel-like factor 10 modulates stem cell phenotypes of pancreatic adenocarcinoma by transcriptionally regulating notch receptors.
KLF10 deficiency in CD4(+) T cells promotes atherosclerosis progression by altering macrophage dynamics.
Title: KLF10 deficiency in CD4(+) T cells promotes atherosclerosis progression by altering macrophage dynamics.
Klf10 favors Mycobacterium tuberculosis survival by impairing IFN-gamma production and preventing macrophages reprograming to macropinocytosis.
Title: Klf10 favors Mycobacterium tuberculosis survival by impairing IFN-γ production and preventing macrophages reprograming to macropinocytosis.
KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.
Title: KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7.

Submit: New GeneRIF Correction See all GeneRIFs (68)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI115143 (e-PCR)
- UniSTS:180749

NoName (e-PCR)
- UniSTS:224865

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Krueppel-like factor 10

Names: GDNF-inducible factor; Kruppel-like factor 10; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; transcription factor GIF; transforming growth factor-beta-inducible early growth response protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289471.2 → NP_001276400.1 Krueppel-like factor 10 isoform 2

See identical proteins and their annotated locations for NP_001276400.1

Status: VALIDATED

Source sequence(s)

AC122459

Consensus CDS

CCDS88752.1

UniProtKB/TrEMBL

Q3U3K0, Q8C900

Related

ENSMUSP00000154265.2, ENSMUST00000227920.2

Conserved Domains (4) summary

COG5048
Location:373 → 423

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:373 → 392

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:368 → 392

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:384 → 411

zf-H2C2_2; Zinc-finger double domain
NM_001357677.2 → NP_001344606.2 Krueppel-like factor 10 isoform 3

Status: VALIDATED

Source sequence(s)

AC122459
NM_013692.4 → NP_038720.1 Krueppel-like factor 10 isoform 1

See identical proteins and their annotated locations for NP_038720.1

Status: VALIDATED

Source sequence(s)

AC122459

Consensus CDS

CCDS27438.1

UniProtKB/Swiss-Prot

O89091

UniProtKB/TrEMBL

Q3U3K0

Related

ENSMUSP00000073690.6, ENSMUST00000074043.7

Conserved Domains (3) summary

sd00017
Location:373 → 392

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:428 → 450

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:414 → 437

zf-H2C2_2; Zinc-finger double domain