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    Ankrd34b ankyrin repeat domain 34B [ Mus musculus (house mouse) ]

    Gene ID: 218440, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ankrd34bprovided by MGI
    Official Full Name
    ankyrin repeat domain 34Bprovided by MGI
    Primary source
    MGI:MGI:2443245
    See related
    Ensembl:ENSMUSG00000045034 AllianceGenome:MGI:2443245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DP58; 6430502M16Rik
    Summary
    Predicted to be located in cytoplasm and nucleus. Orthologous to human ANKRD34B (ankyrin repeat domain 34B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 4.7), frontal lobe adult (RPKM 1.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    13 C3; 13 47.68 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (92562413..92578166)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (92425905..92441658)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene mutS homolog 3 Neighboring gene STARR-positive B cell enhancer mm9_chr13:93090941-93091242 Neighboring gene predicted gene, 20379 Neighboring gene STARR-positive B cell enhancer ABC_E8539 Neighboring gene STARR-positive B cell enhancer ABC_E2416 Neighboring gene 60S ribosomal protein L32 pseudogene Neighboring gene dihydrofolate reductase Neighboring gene family with sequence similarity 151, member B Neighboring gene STARR-seq mESC enhancer starr_35266 Neighboring gene predicted gene, 52060 Neighboring gene zinc finger, FYVE domain containing 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel cell-surface protein CSP82 on bone marrow stem cells and a cytosolic phosphoprotein DP58 (ankyrinRD 34B) are involved in promyeloid progenitor induction. Al-Shaibi N, et al. Cell Immunol, 2009. PMID 19524877
    2. A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. Al-Shaibi N, et al. Biochem Biophys Res Commun, 2004 Aug 13. PMID 15358210
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cytosolic phosphoprotein DP58 is involved in promyeloid progenitor induction.
      Title: A novel cell-surface protein CSP82 on bone marrow stem cells and a cytosolic phosphoprotein DP58 (ankyrinRD 34B) are involved in promyeloid progenitor induction.
    2. Because of its restricted expression in bone-marrow-drived progenitors as a phophorylated protein, it is likely that DP58 may be involved in a signaling pathway for cellular differentiation.
      Title: A novel phosphoprotein is induced during bone marrow commitment to dendritic cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 34B
    Names
    cytosolic phosphoprotein DP58
    dendritic cell progenitor protein of 58 kDa
    dendritic phosphoprotein 58 kDa
    dendritic protein of 58 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175455.4 → NP_780664.2  ankyrin repeat domain-containing protein 34B

      See identical proteins and their annotated locations for NP_780664.2

      Status: VALIDATED

      Source sequence(s)
      AK078203, AK138465, AW489260, BC119314, BE649643
      Consensus CDS
      CCDS26681.1
      UniProtKB/Swiss-Prot
      Q3UUF8, Q4VA01, Q8BVH7
      Related
      ENSMUSP00000054330.7, ENSMUST00000061594.13
      Conserved Domains (2) summary
      sd00045
      Location:42 → 81
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:31 → 115
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      92562413..92578166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244638.3 → XP_011242940.1  ankyrin repeat domain-containing protein 34B isoform X1

      See identical proteins and their annotated locations for XP_011242940.1

      UniProtKB/Swiss-Prot
      Q3UUF8, Q4VA01, Q8BVH7
      Conserved Domains (2) summary
      sd00045
      Location:42 → 81
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:31 → 115
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_036158011.1 → XP_036013904.1  ankyrin repeat domain-containing protein 34B isoform X1

      UniProtKB/Swiss-Prot
      Q3UUF8, Q4VA01, Q8BVH7
      Related
      ENSMUSP00000126289.2, ENSMUST00000168871.2
      Conserved Domains (2) summary
      sd00045
      Location:42 → 81
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:31 → 115
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UUF8.1 GenPept UniProtKB/Swiss-Prot:Q3UUF8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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