Rfesd Rieske (Fe-S) domain containing [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rfesdprovided by MGI
Official Full Name: Rieske (Fe-S) domain containingprovided by MGI
Primary source: MGI:MGI:2145198
See related: Ensembl:ENSMUSG00000043190 AllianceGenome:MGI:2145198
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D030068K09
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity and metal ion binding activity. Is expressed in several structures, including heart; liver; placenta; spinal cord floor plate; and trunk somite. Orthologous to human RFESD (Rieske Fe-S domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14 (RPKM 11.2), liver E14.5 (RPKM 7.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C1; 13 40.95 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (76149654..76166831, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (76001535..76018712, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings together provide novel evidence that mitochondria are the direct hypoxic targets in PASMCs, in which Rieske iron-sulfur protein in complex III may serve as an essential, primary molecule that mediates the hypoxic ROS generation
Title: Primary role of mitochondrial Rieske iron-sulfur protein in hypoxic ROS production in pulmonary artery myocytes.
mouse Rieske-type ferredoxin was shown to be capable of accepting electrons from both eukaryotic and prokaryotic oxidoreductases, although it was unable to serve as an electron donor for a bacterial monooxygenase complex.
Title: X-ray structure of a soluble Rieske-type ferredoxin from Mus musculus.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: Rieske domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131068.1 → NP_001124540.1 Rieske domain-containing protein

See identical proteins and their annotated locations for NP_001124540.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AK040255, AK083705, CO796218

Consensus CDS

CCDS26654.1

UniProtKB/Swiss-Prot

Q3TQH9, Q8K2P6

Related

ENSMUSP00000136314.2, ENSMUST00000179078.9

Conserved Domains (1) summary

cd03467
Location:18 → 96

Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
NM_001131069.1 → NP_001124541.1 Rieske domain-containing protein

See identical proteins and their annotated locations for NP_001124541.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1.

Source sequence(s)

AK083705, CD769672, CN839985

Consensus CDS

CCDS26654.1

UniProtKB/Swiss-Prot

Q3TQH9, Q8K2P6

Related

ENSMUSP00000130366.2, ENSMUST00000167271.9

Conserved Domains (1) summary

cd03467
Location:18 → 96

Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...
NM_178916.5 → NP_849247.3 Rieske domain-containing protein

See identical proteins and their annotated locations for NP_849247.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AK040255, AK083705

Consensus CDS

CCDS26654.1

UniProtKB/Swiss-Prot

Q3TQH9, Q8K2P6

Related

ENSMUSP00000055763.2, ENSMUST00000050997.2

Conserved Domains (1) summary

cd03467
Location:18 → 96

Rieske; Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes. ...