Zfp595 zinc finger protein 595 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp595provided by MGI
Official Full Name: zinc finger protein 595provided by MGI
Primary source: MGI:MGI:3040707
See related: Ensembl:ENSMUSG00000057842 AllianceGenome:MGI:3040707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rslcan23; A230042K10Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in testis and thyroid gland. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF208 (zinc finger protein 208); and ZNF43 (zinc finger protein 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 1.3), limb E14.5 (RPKM 0.8) and 24 other tissues See more
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Genomic context

Location:: 13 B3; 13 34.54 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (67461049..67491018, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (67312985..67342954, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zin finger protein 595

Names: KRAB zinc finger protein; regulator of sex-limitation candidate 23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001374733.1 → NP_001361662.1 zin finger protein 595 isoform 2

Status: VALIDATED

Source sequence(s)

AC154510, AC164116

Consensus CDS

CCDS88476.1

UniProtKB/TrEMBL

B9EIT6

Related

ENSMUSP00000127010.2, ENSMUST00000171466.2

Conserved Domains (4) summary

smart00349
Location:2 → 60

KRAB; krueppel associated box

COG5048
Location:107 → 490

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:493 → 563

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:248 → 268

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_177622.3 → NP_808290.1 zin finger protein 595 isoform 1

See identical proteins and their annotated locations for NP_808290.1

Status: VALIDATED

Source sequence(s)

AK136304, BB632383, BK001632

Consensus CDS

CCDS36712.1

UniProtKB/TrEMBL

Q8BIN6

Related

ENSMUSP00000105357.3, ENSMUST00000109735.9

Conserved Domains (4) summary

smart00349
Location:5 → 63

KRAB; krueppel associated box

COG5048
Location:110 → 493

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:496 → 566

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:251 → 271

ZF_C2H2; C2H2 Zn finger [structural motif]