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    Thbs3 thrombospondin 3 [ Mus musculus (house mouse) ]

    Gene ID: 21827, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Thbs3provided by MGI
    Official Full Name
    thrombospondin 3provided by MGI
    Primary source
    MGI:MGI:98739
    See related
    Ensembl:ENSMUSG00000028047 AllianceGenome:MGI:98739
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TSP3; Thbs-3
    Summary
    Predicted to enable heparin binding activity. Acts upstream of or within bone trabecula formation; growth plate cartilage development; and ossification involved in bone maturation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in collagen-containing extracellular matrix. Is expressed in several structures, including brain; lung; musculoskeletal system; sensory organ; and urinary system. Orthologous to human THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 35.8), lung adult (RPKM 25.6) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 39.01 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89122470..89134148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89215180..89226841)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E11197 Neighboring gene STARR-seq mESC enhancer starr_08226 Neighboring gene predicted gene, 57704 Neighboring gene STARR-positive B cell enhancer ABC_E11198 Neighboring gene microRNA 92b Neighboring gene mucin 1, transmembrane

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling. Hankenson KD, et al. Curr Osteoporos Rep, 2010 Jun. PMID 20425613
    2. SP1-binding elements, within the common metaxin-thrombospondin 3 intergenic region, participate in the regulation of the metaxin gene. Collins M, et al. Nucleic Acids Res, 1996 Oct 1. PMID 8871542, Free PMC Article
    3. Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3. Chen H, et al. FEBS Lett, 1996 May 27. PMID 8654563
    4. Isolation and characterization of the mouse thrombospondin 3 (Thbs3) gene. Bornstein P, et al. Genomics, 1993 Mar. PMID 8468055
    5. Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Hankenson KD, et al. Mol Cell Biol, 2005 Jul. PMID 15964815, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone trabecula formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within growth plate cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within growth plate cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thrombospondin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013691.3 → NP_038719.2  thrombospondin-3 precursor

      See identical proteins and their annotated locations for NP_038719.2

      Status: VALIDATED

      Source sequence(s)
      AC161600, BC053023, BP754474, CJ064850
      Consensus CDS
      CCDS17495.1
      UniProtKB/Swiss-Prot
      Q05895, Q6LCE0, Q7TN15
      UniProtKB/TrEMBL
      E9PWF0
      Related
      ENSMUSP00000029682.5, ENSMUST00000029682.11
      Conserved Domains (9) summary
      cd00054
      Location:316 → 352
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:528 → 550
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:551 → 586
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:457 → 491
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:552 → 586
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:741 → 938
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:378 → 407
      EGF_3; EGF domain
      cd16079
      Location:227 → 269
      TSP-3cc; Coiled coil region of thrombospondin-3 (TSP-3)
      cl22861
      Location:21 → 193
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RNA

    1. NR_149740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132327, AC161600, BP754474
      Related
      ENSMUST00000126315.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89122470..89134148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501295.3 → XP_006501358.1  thrombospondin-3 isoform X1

      Conserved Domains (8) summary
      cd00054
      Location:111 → 147
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:323 → 345
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:346 → 381
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:252 → 286
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:346 → 381
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:536 → 733
      TSP_C; Thrombospondin C-terminal region
      pfam12947
      Location:173 → 202
      EGF_3; EGF domain
      NF000535
      Location:257 → 447
      MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05895.2 GenPept UniProtKB/Swiss-Prot:Q05895

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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