Thbd thrombomodulin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thbdprovided by MGI
Official Full Name: thrombomodulinprovided by MGI
Primary source: MGI:MGI:98736
See related: Ensembl:ENSMUSG00000074743 AllianceGenome:MGI:98736
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TM; CD141
Summary: Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 2 G3; 2 73.45 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (148246391..148250108, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (148404471..148408188, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis.
Title: Epigenetic repression of THBD transcription by BRG1 contributes to deep vein thrombosis.
Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses.
Title: Absence of the lectin-like domain of thrombomodulin reduces HSV-1 lethality of mice with increased microglia responses.
Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.
Title: Placental thromboinflammation impairs embryonic survival by reducing placental thrombomodulin expression.
Role of thrombomodulin expression on hematopoietic stem cells.
Title: Role of thrombomodulin expression on hematopoietic stem cells.
Reduced Glomerular Endothelial Thrombomodulin Is Associated with Glomerular Macrophage Infiltration in Diabetic Nephropathy.
Title: Reduced Glomerular Endothelial Thrombomodulin Is Associated with Glomerular Macrophage Infiltration in Diabetic Nephropathy.
Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report.
Title: Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain-Brief Report.
In Erg deletion(iEC-KO) mice, thrombomodulin (TM) expression is decreased in liver and lung microvasculature exposed to low shear stress (SS) but not in blood vessels exposed to high SS.
Title: The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature.
Plasminogen (Plg) binds to thrombomodulin (TM) in cutaneous wound healing. TM facilitates the activation of Plg to Plm in keratinocytes. Epithelial TM regulates Plg-enhanced wound healing through VEGF expression. Our findings suggest that activation of Plg/TM signaling may hold therapeutic potential for chronic wounds in diabetic or non-diabetic individuals.
Title: Plasminogen/thrombomodulin signaling enhances VEGF expression to promote cutaneous wound healing.
macrophage infiltration and neointima formation following arterial ligation-induced vascular injury were higher in wild-type than in myeloid-specific thrombomodulin-deficient mice
Title: Monocytic thrombomodulin promotes cell adhesion through interacting with its ligand, Lewis(y).
discovery of a novel physiological function of thrombomodulin-dependent activated protein C generation within the CNS
Title: Thrombomodulin-dependent protein C activation is required for mitochondrial function and myelination in the central nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (12) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI385582 (e-PCR)
- UniSTS:178728

Iap2-1 (e-PCR), detects polymorphism
- UniSTS:143438

Thbd (e-PCR), detects polymorphism
- UniSTS:498512

D19Mit15 (e-PCR), detects polymorphism
- UniSTS:128354

PMC209404P1 (e-PCR)
- UniSTS:271990

Thbd (e-PCR), detects polymorphism
- UniSTS:525950

X14432 (e-PCR)
- UniSTS:163298

Thbd (e-PCR), detects polymorphism
- UniSTS:144617

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood coagulation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within female pregnancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of coagulation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apicolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of serine-type endopeptidase complex	ISO Inferred from Sequence Orthology more info
located_in vacuolar membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thrombomodulin

Names: fetomodulin; snoRNA MBII-339

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009378.3 → NP_033404.1 thrombomodulin precursor

See identical proteins and their annotated locations for NP_033404.1

Status: VALIDATED

Source sequence(s)

AL935149

Consensus CDS

CCDS16838.1

UniProtKB/Swiss-Prot

P15306

UniProtKB/TrEMBL

Q543W3, Q8BJB5

Related

ENSMUSP00000096877.4, ENSMUST00000099270.5

Conserved Domains (5) summary

pfam06247
Location:346 → 467

Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28

pfam07645
Location:324 → 360

EGF_CA; Calcium-binding EGF domain

pfam09064
Location:405 → 438

Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like

pfam14670
Location:244 → 279

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl02432
Location:30 → 169

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain