Tgfb2 transforming growth factor, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 21808, updated on 22-Apr-2024

Summary

Official Symbol: Tgfb2provided by MGI
Official Full Name: transforming growth factor, beta 2provided by MGI
Primary source: MGI:MGI:98726
See related: Ensembl:ENSMUSG00000039239 AllianceGenome:MGI:98726
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tgfb-2; Tgf-beta2
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Mice lacking a functional copy of this gene display developmental defects in multiple organs and perinatal lethality. Heterozygous mutant mice exhibit aortic root aneurysm. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016]
Expression: Broad expression in limb E14.5 (RPKM 8.0), CNS E11.5 (RPKM 3.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1 89.95 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (186354984..186441504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (186622787..186709697, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.
Title: Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.
The Research Progress in Transforming Growth Factor-beta2.
Title: The Research Progress in Transforming Growth Factor-β2.
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFbeta2 signaling pathway.
Title: miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.
TGFbeta-2 haploinsufficiency causes early death in mice with Marfan syndrome.
Title: TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome.
TGF-beta2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.
Title: TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.
Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-beta1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice.
Title: Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice.
TGF-beta2 Regulates Transcription of the K[+]/Cl[-] Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons.
Title: TGF-β2 Regulates Transcription of the K(+)/Cl(-) Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons.
Oocyte-secreted factor TGFB2 enables mouse cumulus cell expansion in vitro.
Title: Oocyte-secreted factor TGFB2 enables mouse cumulus cell expansion in vitro.
TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
Title: TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
TGFbeta2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma.
Title: TGFβ2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tgfb2 (e-PCR), detects polymorphism
- UniSTS:496698

D1Mit461 (e-PCR), detects polymorphism
- UniSTS:128831

Tgfb2 (e-PCR), detects polymorphism
- UniSTS:547653

Tgfb2 (e-PCR), detects polymorphism
- UniSTS:480352

Tgfb2 (e-PCR), detects polymorphism
- UniSTS:474722

X57413 (e-PCR)
- UniSTS:125804

BB105277 (e-PCR)
- UniSTS:185461

UniSTS:224971 (e-PCR)
- UniSTS:224971

Tgfb2 (e-PCR), detects polymorphism
- UniSTS:144612

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info
enables type III transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of activation-induced cell death of T cells	IDA Inferred from Direct Assay more info	PubMed
involved_in ascending aorta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrial septum primum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac left ventricle morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac right ventricle morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in cardioblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell-cell junction organization	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in cranial skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic limb morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic neurocranium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endocardial cushion fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocardial cushion morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in face morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in glial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membranous septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of macrophage cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outflow tract morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in outflow tract septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pericyte cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pharyngeal arch artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTP binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activation-induced cell death of T cells	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardioblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extracellular matrix disassembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of integrin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of timing of catagen	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process involved in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of timing of catagen	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta2 production	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to progesterone	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in substantia propria of cornea development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in uterus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventricular septum morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in ventricular trabecula myocardium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming growth factor beta-2 proprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001329107.1 → NP_001316036.1 transforming growth factor beta-2 proprotein isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is longer than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.

Source sequence(s)

AC154879, AK029306, AK141552, AK159690, AK163286

Consensus CDS

CCDS83659.1

UniProtKB/TrEMBL

A0A0A6YXU9

Related

ENSMUSP00000142149.2, ENSMUST00000195201.2

Conserved Domains (2) summary

pfam00019
Location:344 → 441

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:21 → 256

TGFb_propeptide; TGF-beta propeptide
NM_009367.4 → NP_033393.2 transforming growth factor beta-2 proprotein isoform 1 preproprotein

See identical proteins and their annotated locations for NP_033393.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).

Source sequence(s)

AC154879, AK029306, AK159690, AK163286

Consensus CDS

CCDS15601.1

UniProtKB/Swiss-Prot

P27090, Q91VP5

UniProtKB/TrEMBL

Q3TWH5

Related

ENSMUSP00000043849.9, ENSMUST00000045288.14

Conserved Domains (2) summary

pfam00019
Location:316 → 413

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:21 → 228

TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

186354984..186441504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252968.2 → XP_030108828.1 transforming growth factor beta-2 proprotein isoform X2

Conserved Domains (1) summary

pfam00688
Location:21 → 228

TGFb_propeptide; TGF-beta propeptide
XM_006497136.5 → XP_006497199.1 transforming growth factor beta-2 proprotein isoform X1

Conserved Domains (1) summary

pfam00688
Location:21 → 256

TGFb_propeptide; TGF-beta propeptide