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    Tsc22d1 TSC22 domain family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 21807, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tsc22d1provided by MGI
    Official Full Name
    TSC22 domain family, member 1provided by MGI
    Primary source
    MGI:MGI:109127
    See related
    Ensembl:ENSMUSG00000022010 AllianceGenome:MGI:109127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tsc; Egr5; Tsc22; TSC-22; Gm19597; Tgfb1i4
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of apoptotic process; positive regulation of apoptotic process; and positive regulation of cell population proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 53.8), CNS E14 (RPKM 43.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 D3; 14 40.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76652401..76745205)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76414961..76507765)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900040C04 gene Neighboring gene VISTA enhancer mm1502 Neighboring gene STARR-seq mESC enhancer starr_37174 Neighboring gene predicted gene, 41215 Neighboring gene STARR-seq mESC enhancer starr_37176 Neighboring gene STARR-seq mESC enhancer starr_37178 Neighboring gene STARR-seq mESC enhancer starr_37179 Neighboring gene STARR-positive B cell enhancer ABC_E2428 Neighboring gene STARR-seq mESC enhancer starr_37180 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene STARR-seq mESC enhancer starr_37182 Neighboring gene predicted gene, 36845 Neighboring gene stress-associated endoplasmic reticulum protein family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of TSC-22 (transforming growth factor- β-stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice. Uchida D, et al. Oncotarget, 2016 Mar 22. PMID 26872059, Free PMC Article
    2. TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Yu J, et al. Blood, 2009 May 28. PMID 19329776, Free PMC Article
    3. Profile of transforming growth factor-beta responses during the murine hair cycle. Soma T, et al. J Invest Dermatol, 2003 Nov. PMID 14708594
    4. Neurovascular Development in Pten and Tsc2 Mouse Mutants. Dusing M, et al. eNeuro, 2023 Feb. PMID 36759189, Free PMC Article
    5. TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes. Pépin A, et al. J Cell Biochem, 2016 Aug. PMID 26752201

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurovascular Development in Pten and Tsc2 Mouse Mutants.
      Title: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
    2. High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma.
      Title: Overexpression of TSC-22 (transforming growth factor- β-stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice.
    3. These results suggested that TSC-22 could counteract the protective effect of GILZ on IL-2-deprivation-induced apoptosis.
      Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.
    4. Fat4 and Tsc22d1 are likely candidate genes to influence formation of spontaneous pulmonary adenoma in aging male and female mice, respectively.
      Title: Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.
    5. post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-beta-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy
      Title: Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.
    6. novel opposing functions of the two mammalian TSC-22D1 isoforms in cell survival and proliferation, and establish the TSC-22D1 isoform 2 as a potential regulator of cell death during mammary gland involution
      Title: TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.
    7. TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.
      Title: TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia.
    8. Analysis of the regulation of Tgf beta1i4 by Foxc1 in mesenchymal cells isolated from the periocular region revealed that Foxc1 negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1.
      Title: Identification of Tgf beta1i4 as a downstream target of Foxc1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TSC22 domain family protein 1
    Names
    Tgfb-stimulated clone 22 homolog
    Tsc22-related inducible leucine zipper 1b
    regulatory protein Tsc22
    transforming growth factor beta 1 induced transcript 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177751.2 → NP_001171222.1  TSC22 domain family protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC142266, AI841546, AK147039, BY720238
      Consensus CDS
      CCDS49545.1
      UniProtKB/TrEMBL
      D3YW86
      Related
      ENSMUSP00000099140.3, ENSMUST00000101618.9
      Conserved Domains (1) summary
      pfam01166
      Location:22 → 68
      TSC22; TSC-22/dip/bun family

    2. NM_001310646.1 → NP_001297575.1  TSC22 domain family protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001297575.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate splice structure in its 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AC134842, AI841546, AW546174, CX220910
      Consensus CDS
      CCDS79344.1
      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      UniProtKB/TrEMBL
      D3Z0V7
      Related
      ENSMUSP00000106513.2, ENSMUST00000110888.8
      Conserved Domains (2) summary
      PHA03247
      Location:486 → 796
      PHA03247; large tegument protein UL36; Provisional
      pfam01166
      Location:910 → 956
      TSC22; TSC-22/dip/bun family

    3. NM_001310647.1 → NP_001297576.1  TSC22 domain family protein 1 isoform 5

      See identical proteins and their annotated locations for NP_001297576.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks the 5' and central coding regions, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (5) is significantly shorter than isoform 1.
      Source sequence(s)
      AI841546, AW546174, CX220910
      Consensus CDS
      CCDS79345.1
      UniProtKB/TrEMBL
      H3BLI9
      Related
      ENSMUSP00000135296.2, ENSMUST00000177207.2
      Conserved Domains (1) summary
      cl40461
      Location:1 → 74
      ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

    4. NM_009366.4 → NP_033392.1  TSC22 domain family protein 1 isoform 2

      See identical proteins and their annotated locations for NP_033392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AI841546, AK147039
      Consensus CDS
      CCDS27286.1
      UniProtKB/TrEMBL
      Q3UXU0
      Related
      ENSMUSP00000022587.10, ENSMUST00000022587.10
      Conserved Domains (1) summary
      cd21938
      Location:53 → 131
      ZIP_TSC22D1; leucine zipper domain found in TSC22 domain family protein 1

    5. NM_207652.3 → NP_997535.2  TSC22 domain family protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI841546, AK147039, BC058660
      Consensus CDS
      CCDS27285.2
      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      UniProtKB/TrEMBL
      E9QLZ1
      Related
      ENSMUSP00000044517.9, ENSMUST00000048371.15
      Conserved Domains (2) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam01166
      Location:992 → 1038
      TSC22; TSC-22/dip/bun family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      76652401..76745205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017315943.2 → XP_017171432.1  TSC22 domain family protein 1 isoform X2

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      UniProtKB/TrEMBL
      E9QLZ1
      Conserved Domains (2) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam01166
      Location:992 → 1038
      TSC22; TSC-22/dip/bun family

    2. XM_017315942.2 → XP_017171431.1  TSC22 domain family protein 1 isoform X2

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      UniProtKB/TrEMBL
      E9QLZ1
      Conserved Domains (2) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional
      pfam01166
      Location:992 → 1038
      TSC22; TSC-22/dip/bun family

    3. XM_006518803.4 → XP_006518866.1  TSC22 domain family protein 1 isoform X6

      See identical proteins and their annotated locations for XP_006518866.1

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      UniProtKB/TrEMBL
      D3Z0V7
      Conserved Domains (2) summary
      PHA03247
      Location:486 → 796
      PHA03247; large tegument protein UL36; Provisional
      pfam01166
      Location:910 → 956
      TSC22; TSC-22/dip/bun family

    4. XM_017315945.2 → XP_017171434.1  TSC22 domain family protein 1 isoform X5

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      Conserved Domains (1) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional

    5. XM_006518799.3 → XP_006518862.1  TSC22 domain family protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      Conserved Domains (1) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional

    6. XM_006518801.3 → XP_006518864.1  TSC22 domain family protein 1 isoform X4

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      Conserved Domains (1) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional

    7. XM_006518800.3 → XP_006518863.1  TSC22 domain family protein 1 isoform X3

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      Conserved Domains (1) summary
      PHA03247
      Location:568 → 878
      PHA03247; large tegument protein UL36; Provisional

    8. XM_036158535.1 → XP_036014428.1  TSC22 domain family protein 1 isoform X7

      UniProtKB/Swiss-Prot
      P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4
      Conserved Domains (1) summary
      PHA03247
      Location:486 → 796
      PHA03247; large tegument protein UL36; Provisional

    RNA

    1. XR_004938376.1 RNA Sequence

    2. XR_003950835.1 RNA Sequence

    3. XR_001781104.2 RNA Sequence

    4. XR_001781105.2 RNA Sequence

    5. XR_383154.3 RNA Sequence

    6. XR_003950836.1 RNA Sequence

    7. XR_004938375.1 RNA Sequence

    8. XR_383156.3 RNA Sequence

    9. XR_003950837.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62500.2 GenPept UniProtKB/Swiss-Prot:P62500

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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