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    Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [ Mus musculus (house mouse) ]

    Gene ID: 217944, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rapgef5provided by MGI
    Official Full Name
    Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
    Primary source
    MGI:MGI:2444365
    See related
    Ensembl:ENSMUSG00000041992 AllianceGenome:MGI:2444365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GFR; Mrgef; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
    Summary
    Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to be located in nuclear body. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart and pericardium; and sensory organ. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F2; 12 63.06 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (117480146..117723472)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (117516526..117759737)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:118623787-118624087 Neighboring gene predicted gene, 39559 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:118685906-118686089 Neighboring gene predicted gene, 31482 Neighboring gene STARR-positive B cell enhancer ABC_E4048 Neighboring gene STARR-seq mESC enhancer starr_33424 Neighboring gene STARR-seq mESC enhancer starr_33425 Neighboring gene predicted gene, 53774 Neighboring gene STARR-positive B cell enhancer mm9_chr12:119003289-119003590 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr12:119058566-119058867 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene dynein, axonemal, heavy chain 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the guanine nucleotide exchange factor, RAPGEF5, during mouse and human embryogenesis. Alharatani R, et al. Gene Expr Patterns, 2019 Dec. PMID 31163262
    2. Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder. Bithell A, et al. PLoS One, 2010 Apr 28. PMID 20436929, Free PMC Article
    3. Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants. Codner GF, et al. BMC Biol, 2018 Jun 21. PMID 29925374, Free PMC Article
    4. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Bithell A, et al. Brain Res Dev Brain Res, 2003 Dec 19. PMID 14643017
    5. Dlx transcription factors promote migration through repression of axon and dendrite growth. Cobos I, et al. Neuron, 2007 Jun 21. PMID 17582329, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rap guanine nucleotide exchange factor 5
    Names
    M-Ras-regulated Rap GEF
    MR-GEF
    Mras regulated guanine nucleotide exchange factor
    guanine nucleotide exchange factor for Rap1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001373989.1 → NP_001360918.1  rap guanine nucleotide exchange factor 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC139993, AC163283, AC163286
      Conserved Domains (3) summary
      smart00147
      Location:639 → 878
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:367 → 498
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:98 → 221
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    2. NM_175930.6 → NP_787126.3  rap guanine nucleotide exchange factor 5 isoform 2

      See identical proteins and their annotated locations for NP_787126.3

      Status: VALIDATED

      Source sequence(s)
      AC139993, AC163283, AC163286
      Consensus CDS
      CCDS36577.1
      UniProtKB/Swiss-Prot
      Q8BJJ9, Q8C0Q9, Q8C0R5
      Related
      ENSMUSP00000105313.3, ENSMUST00000109691.4
      Conserved Domains (3) summary
      smart00147
      Location:574 → 813
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:302 → 433
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:33 → 156
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      117480146..117723472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157373.1 → XP_036013266.1  rap guanine nucleotide exchange factor 5 isoform X2

      Conserved Domains (2) summary
      smart00229
      Location:410 → 514
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:141 → 264
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    2. XM_030246682.2 → XP_030102542.1  rap guanine nucleotide exchange factor 5 isoform X1

      Conserved Domains (3) summary
      smart00147
      Location:598 → 837
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:326 → 457
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:57 → 180
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0Q9.2 GenPept UniProtKB/Swiss-Prot:Q8C0Q9

    Gene LinkOut

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