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    Tfpi tissue factor pathway inhibitor [ Mus musculus (house mouse) ]

    Gene ID: 21788, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tfpiprovided by MGI
    Official Full Name
    tissue factor pathway inhibitorprovided by MGI
    Primary source
    MGI:MGI:1095418
    See related
    Ensembl:ENSMUSG00000027082 AllianceGenome:MGI:1095418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EPI; LACI; A630013F22Rik
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of blood coagulation. Predicted to act upstream of or within blood coagulation. Located in extracellular space. Is expressed in several structures, including central nervous system; hemolymphoid system; liver; lung; and retina. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in placenta adult (RPKM 120.5) and heart adult (RPKM 7.2) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 D; 2 49.41 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84263199..84307119, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84432855..84476775, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54167 Neighboring gene calcitonin receptor-like Neighboring gene STARR-positive B cell enhancer mm9_chr2:84263150-84263451 Neighboring gene STARR-positive B cell enhancer ABC_E3384 Neighboring gene STARR-positive B cell enhancer ABC_E5941 Neighboring gene STARR-positive B cell enhancer ABC_E7834 Neighboring gene STARR-positive B cell enhancer ABC_E2040 Neighboring gene STARR-positive B cell enhancer ABC_E4474 Neighboring gene STARR-seq mESC enhancer starr_04996 Neighboring gene VISTA enhancer mm1324 Neighboring gene predicted gene 13710 Neighboring gene STARR-seq mESC enhancer starr_04998 Neighboring gene STARR-seq mESC enhancer starr_04999 Neighboring gene catenin delta 1 Neighboring gene STARR-positive B cell enhancer ABC_E2627

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice. Maroney SA, et al. J Thromb Haemost, 2023 Mar. PMID 36696221, Free PMC Article
    2. The contribution of TFPIα to the hemostatic response to injury in mice. Marar TT, et al. J Thromb Haemost, 2021 Sep. PMID 34160126, Free PMC Article
    3. Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid- and late-gestation by platelet TFPIα overexpression. Siebert AE, et al. J Thromb Haemost, 2021 Jun. PMID 33728763, Free PMC Article
    4. Knockdown of TFPI-Anchored Endothelial Cells Exacerbates Lipopolysaccharide-Induced Acute Lung Injury Via NF-κB Signaling Pathway. Wang BQ, et al. Shock, 2019 Feb. PMID 29438223, Free PMC Article
    5. Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis. Yang J, et al. Front Med, 2017 Sep. PMID 28550640

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation.
      Title: Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation.
    2. Platelet tissue factor pathway inhibitor-alpha dampens cardiac thrombosis and associated fibrosis in mice.
      Title: Platelet tissue factor pathway inhibitor-α dampens cardiac thrombosis and associated fibrosis in mice.
    3. Promoting plaque stability by gene silencing of monocyte chemotactic protein-3 or overexpression of tissue factor pathway inhibitor in ApoE-/- mice.
      Title: Promoting plaque stability by gene silencing of monocyte chemotactic protein-3 or overexpression of tissue factor pathway inhibitor in ApoE-/- mice.
    4. The contribution of TFPIalpha to the hemostatic response to injury in mice.
      Title: The contribution of TFPIα to the hemostatic response to injury in mice.
    5. Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid- and late-gestation by platelet TFPIalpha overexpression.
      Title: Intrauterine lethality in Tfpi gene disrupted mice is differentially suppressed during mid- and late-gestation by platelet TFPIα overexpression.
    6. Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
      Title: Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality.
    7. Tissue factor pathway inhibitor is required for cerebrovascular development in mice.
      Title: Tissue factor pathway inhibitor is required for cerebrovascular development in mice.
    8. Endothelial-specific TFPI deficiency promoted LPS-induced pulmonary inflammation and endothelial barrier permeability possibly via toll-like receptor 4-mediated nuclear factor kappa-light-chain-enhancer of activated B cells signaling pathway activation.
      Title: Knockdown of TFPI-Anchored Endothelial Cells Exacerbates Lipopolysaccharide-Induced Acute Lung Injury Via NF-κB Signaling Pathway.
    9. endogenous TFPI from vascular smooth muscle cells inhibited ferric chloride-induced arterial thrombosis without causing hemostatic effects
      Title: Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis.
    10. TFPI-1 interacts with AMOT, which led to a decrease in the phosphorylation of YAP and further increased the genes expression of the proliferation and migration involved. Our results further confirmed that atherosclerosis was a localized disease.
      Title: Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (33)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hemostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tissue factor pathway inhibitor
    Names
    extrinsic pathway inhibitor
    lipoprotein-associated coagulation inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177319.1 → NP_001170790.1  tissue factor pathway inhibitor isoform b precursor

      See identical proteins and their annotated locations for NP_001170790.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AK034752, AL845305, BY307762
      Consensus CDS
      CCDS50620.1
      UniProtKB/TrEMBL
      Q8BSB7, Q8CI80
      Related
      ENSMUSP00000107343.2, ENSMUST00000111714.8
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:120 → 171
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. NM_001177320.1 → NP_001170791.1  tissue factor pathway inhibitor isoform b precursor

      See identical proteins and their annotated locations for NP_001170791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2 and 3 both encode isoform b.
      Source sequence(s)
      AK034752, AL845305
      Consensus CDS
      CCDS50620.1
      UniProtKB/TrEMBL
      Q8BSB7, Q8CI80
      Related
      ENSMUSP00000088235.4, ENSMUST00000090732.10
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:120 → 171
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    3. NM_001355271.1 → NP_001342200.1  tissue factor pathway inhibitor isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AL845305
      Consensus CDS
      CCDS16185.1
      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Related
      ENSMUSP00000107351.2, ENSMUST00000111722.8
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    4. NM_001355273.1 → NP_001342202.1  tissue factor pathway inhibitor isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AL845305
      Consensus CDS
      CCDS16185.1
      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    5. NM_011576.1 → NP_035706.1  tissue factor pathway inhibitor isoform a precursor

      See identical proteins and their annotated locations for NP_035706.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 4, and 5 all encode the same isoform (a).
      Source sequence(s)
      AK028356
      Consensus CDS
      CCDS16185.1
      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Related
      ENSMUSP00000028487.4, ENSMUST00000028487.10
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      84263199..84307119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160427.1 → XP_036016320.1  tissue factor pathway inhibitor isoform X1

      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    2. XM_030249392.2 → XP_030105252.1  tissue factor pathway inhibitor isoform X1

      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    3. XM_006499145.3 → XP_006499208.1  tissue factor pathway inhibitor isoform X1

      See identical proteins and their annotated locations for XP_006499208.1

      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Related
      ENSMUSP00000107347.2, ENSMUST00000111718.8
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    4. XM_030249395.1 → XP_030105255.1  tissue factor pathway inhibitor isoform X1

      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    5. XM_036160428.1 → XP_036016321.1  tissue factor pathway inhibitor isoform X1

      UniProtKB/Swiss-Prot
      O54819, Q9Z2U8
      UniProtKB/TrEMBL
      A2ARA0
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:224 → 276
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    6. XM_006499149.5 → XP_006499212.1  tissue factor pathway inhibitor isoform X2

      UniProtKB/TrEMBL
      A2ARA3
      Related
      ENSMUSP00000122776.2, ENSMUST00000150261.8
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:120 → 171
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

    7. XM_006499150.4 → XP_006499213.1  tissue factor pathway inhibitor isoform X3

      See identical proteins and their annotated locations for XP_006499213.1

      UniProtKB/TrEMBL
      Q8BSB7, Q8CI80
      Conserved Domains (2) summary
      cd00109
      Location:48 → 101
      KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
      pfam00014
      Location:120 → 171
      Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54819.1 GenPept UniProtKB/Swiss-Prot:O54819

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