Tff3 trefoil factor 3, intestinal [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tff3provided by MGI
Official Full Name: trefoil factor 3, intestinalprovided by MGI
Primary source: MGI:MGI:104638
See related: Ensembl:ENSMUSG00000024029 AllianceGenome:MGI:104638
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ITF; mITF
Summary: Predicted to enable identical protein binding activity. Involved in regulation of glucose metabolic process. Located in secretory granule. Is expressed in several structures, including alimentary system; ear; liver and biliary system; musculoskeletal system; and nervous system. Orthologous to human TFF3 (trefoil factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 4647.7), duodenum adult (RPKM 2260.8) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.8 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (31344280..31348585, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (31125306..31129611, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tff3 Deficiency Differentially Affects the Morphology of Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model.
Title: Tff3 Deficiency Differentially Affects the Morphology of Male and Female Intestines in a Long-Term High-Fat-Diet-Fed Mouse Model.
Tff3[-/-] Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week.
Title: Tff3(-/-) Knock-Out Mice with Altered Lipid Metabolism Exhibit a Lower Level of Inflammation following the Dietary Intake of Sodium Chloride for One Week.
Augmented leptin-induced trefoil factor 3 expression and epidermal growth factor receptor transactivation differentially influences neoplasia progression in the stomach and colorectum of dietary fat-induced obese mice.
Title: Augmented leptin-induced trefoil factor 3 expression and epidermal growth factor receptor transactivation differentially influences neoplasia progression in the stomach and colorectum of dietary fat-induced obese mice.
Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Title: Liver-specific decrease in Tff3 gene expression in infant mice perinatally exposed to 2,3,7,8-tetrabromodibenzofuran or 2,3,7,8-tetrachlorodibenzo-p-dioxin.
TFF3 mediates the NF-kappaB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis.
Title: TFF3 mediates the NF-κB/COX2 pathway to regulate PMN-MDSCs activation and protect against necrotizing enterocolitis.
our results suggested that hepatic Tff3 could be effectively used as a potential therapy target for the treatment of nonalcoholic fatty liver disease
Title: Mouse trefoil factor 3 ameliorated high-fat-diet-induced hepatic steatosis via increasing peroxisome proliferator-activated receptor-α-mediated fatty acid oxidation.
Our results indicate that Tff3 depletion led to diminished ER stress response, specifically the PERK pathway.
Title: Impact of High Salt Diet on Cerebral Vascular Function and Stroke in Tff3(-/-)/C57BL/6N Knockout and WT (C57BL/6N) Control Mice.
Elevated expression of TFF3 was shown after skeletal trauma. The stimulatory effects on cell motility and migration of MPCs suggest a role of TFF3 in skeletal repair.
Title: Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair.
Data show that trefoil factor 3 (TFF3) - leucine rich repeat receptor and nogo-interacting protein 2 (LINGO2) interactions disrupt EGFR-LINGO2 complexes resulting in enhanced epidermal growth factor receptor (EGFR) signaling.
Title: TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths.
Tff3 deficiency affects the profile and accumulation of fatty acids in the liver, with no obvious oxidative stress increase, although expression/activity of monitored enzymes is changed as well as the level of SIRT1 and PPARgamma protein.
Title: Trefoil Factor 3 Deficiency Affects Liver Lipid Metabolism.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

D38410 (e-PCR)
- UniSTS:180992

Tff3 (e-PCR), detects polymorphism
- UniSTS:259663

Tff3 (e-PCR), detects polymorphism
- UniSTS:259156

566K2-T7 (e-PCR), detects polymorphism
- UniSTS:140971

Tff3 (e-PCR), detects polymorphism
- UniSTS:144606

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: trefoil factor 3

Names: intestinal trefoil factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.