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    Eif5 eukaryotic translation initiation factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 217869, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Eif5provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 5provided by MGI
    Primary source
    MGI:MGI:95309
    See related
    Ensembl:ENSMUSG00000021282 AllianceGenome:MGI:95309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D12Ertd549e; 2810011H21Rik
    Summary
    Predicted to enable GDP-dissociation inhibitor activity; eukaryotic initiation factor eIF2 binding activity; and translation initiation factor activity. Predicted to be involved in activation of GTPase activity; cytoplasmic translational initiation; and regulation of translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; dorsal root ganglion; ear; genitourinary system; and retina nuclear layer. Orthologous to human EIF5 (eukaryotic translation initiation factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 62.4), CNS E11.5 (RPKM 53.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eif5 in Genome Data Viewer
    Location:
    12 F1; 12 61.03 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111504535..111513187)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111538101..111546753)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor, alpha-induced protein 2 Neighboring gene predicted gene, 40578 Neighboring gene predicted gene 266 Neighboring gene STARR-positive B cell enhancer ABC_E138 Neighboring gene small nucleolar RNA, H/ACA box 28 Neighboring gene RIKEN cDNA 2810029C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E7187 Neighboring gene MAP/microtubule affinity regulating kinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transient expression of a translation initiation factor is conservatively associated with embryonic gene activation in murine and bovine embryos. De Sousa PA, et al. Biol Reprod, 1998 Oct. PMID 9746750
    2. Genome-wide analysis of sex-specific differences in the mother-child PELAGIE cohort exposed to organophosphate metabolites. Capriati M, et al. Sci Rep, 2023 May 17. PMID 37198424, Free PMC Article
    3. Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Kraushar ML, et al. Proc Natl Acad Sci U S A, 2014 Sep 9. PMID 25157170, Free PMC Article
    4. In-depth protein profiling of the postsynaptic density from mouse hippocampus using data-independent acquisition proteomics. Distler U, et al. Proteomics, 2014 Nov. PMID 25211037
    5. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36374, MGC36509

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP-dissociation inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor eIF2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic initiation factor eIF2 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 5
    Names
    eIF-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173363.5 → NP_775539.1  eukaryotic translation initiation factor 5

      See identical proteins and their annotated locations for NP_775539.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represent the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI391022, AK160828, AK163368, AW547465
      Consensus CDS
      CCDS26180.1
      UniProtKB/Swiss-Prot
      P59325
      UniProtKB/TrEMBL
      Q3TKY2, Q3TQR3
      Related
      ENSMUSP00000126825.2, ENSMUST00000166123.9
      Conserved Domains (2) summary
      cd11561
      Location:231 → 383
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:9 → 128
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    2. NM_178041.2 → NP_829887.1  eukaryotic translation initiation factor 5

      See identical proteins and their annotated locations for NP_829887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI391022, AK159232, AK160828, AW547465
      Consensus CDS
      CCDS26180.1
      UniProtKB/Swiss-Prot
      P59325
      UniProtKB/TrEMBL
      Q3TKY2, Q3TQR3
      Related
      ENSMUSP00000152791.2, ENSMUST00000222375.2
      Conserved Domains (2) summary
      cd11561
      Location:231 → 383
      W2_eIF5; C-terminal W2 domain of eukaryotic translation initiation factor 5
      pfam01873
      Location:9 → 128
      eIF-5_eIF-2B; Domain found in IF2B/IF5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111504535..111513187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59325.1 GenPept UniProtKB/Swiss-Prot:P59325

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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