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    Cdc42bpb CDC42 binding protein kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 217866, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Cdc42bpbprovided by MGI
    Official Full Name
    CDC42 binding protein kinase betaprovided by MGI
    Primary source
    MGI:MGI:2136459
    See related
    Ensembl:ENSMUSG00000021279 AllianceGenome:MGI:2136459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MRCKb
    Summary
    Predicted to enable protein serine/threonine kinase activity and small GTPase binding activity. Predicted to be involved in actomyosin structure organization; cell migration; and peptidyl-threonine phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cell junction; cell projection; and plasma membrane. Predicted to be active in actomyosin and cytoplasm. Orthologous to human CDC42BPB (CDC42 binding protein kinase beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 48.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 60.94 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111259406..111347985, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111292972..111379313, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930595D18 gene Neighboring gene TNF receptor-associated factor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:112477093-112477276 Neighboring gene RIKEN cDNA A230087F16 gene Neighboring gene predicted gene, 51960 Neighboring gene amnionless Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3-like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MRCKβ links Dasm1 to actin rearrangements to promote dendrite development. Wang XX, et al. J Biol Chem, 2021 Jan-Jun. PMID 33933448, Free PMC Article
    2. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain. Kalantry S, et al. Nat Genet, 2001 Apr. PMID 11279523
    3. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
    4. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
    5. An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Witherden AS, et al. Gene, 2002 Jan 23. PMID 11867214

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MRCKbeta links Dasm1 to actin rearrangements to promote dendrite development.
      Title: MRCKβ links Dasm1 to actin rearrangements to promote dendrite development.
    2. First identified and named MRCKb based on sequence similarity to MRCKa (CDC42bpa) and orthology to human MRCKb/CDC42bpb
      Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK beta
    Names
    DMPK-like beta
    MRCK beta
    myotonic dystrophy kinase related CDC42 binding kinase beta
    myotonic dystrophy protein kinase like beta
    NP_898837.2
    XP_006515826.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183016.2 → NP_898837.2  serine/threonine-protein kinase MRCK beta

      See identical proteins and their annotated locations for NP_898837.2

      Status: VALIDATED

      Source sequence(s)
      AC127580
      Consensus CDS
      CCDS26176.1
      UniProtKB/Swiss-Prot
      E9QK15, Q69ZR5, Q7TT50, Q80W33
      UniProtKB/TrEMBL
      B2RQQ7
      Related
      ENSMUSP00000042565.4, ENSMUST00000041965.5
      Conserved Domains (8) summary
      pfam08826
      Location:878 → 939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1027 → 1076
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1086 → 1220
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1246 → 1512
      CNH; CNH domain
      pfam13868
      Location:426 → 786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      111259406..111347985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515763.4 → XP_006515826.1  serine/threonine-protein kinase MRCK beta isoform X1

      UniProtKB/TrEMBL
      B2RQQ7
      Conserved Domains (6) summary
      COG0419
      Location:429 → 933
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1044 → 1093
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1103 → 1237
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1263 → 1529
      CNH; CNH domain
      pfam15796
      Location:527 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. XR_004937489.1 RNA Sequence

    2. XR_001780447.3 RNA Sequence

    3. XR_004937490.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TT50.2 GenPept UniProtKB/Swiss-Prot:Q7TT50

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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