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    Zfyve1 zinc finger, FYVE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 217695, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zfyve1provided by MGI
    Official Full Name
    zinc finger, FYVE domain containing 1provided by MGI
    Primary source
    MGI:MGI:3026685
    See related
    Ensembl:ENSMUSG00000042628 AllianceGenome:MGI:3026685
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DFCP1; TAFF1; ZNFN2A1; mKIAA1589; G630053K23
    Summary
    Predicted to enable phosphatidylinositol binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in lipid droplet formation. Located in several cellular components, including Golgi apparatus; lipid droplet; and mitochondrion. Orthologous to human ZFYVE1 (zinc finger FYVE-type containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.4), liver adult (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 38.76 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (83593330..83679289, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (83546556..83597245, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene double PHD fingers 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:84716828-84716981 Neighboring gene STARR-positive B cell enhancer ABC_E3060 Neighboring gene STARR-positive B cell enhancer ABC_E9860 Neighboring gene STARR-seq mESC enhancer starr_32707 Neighboring gene STARR-seq mESC enhancer starr_32708 Neighboring gene DDB1 and CUL4 associated factor 4 Neighboring gene STARR-seq mESC enhancer starr_32712 Neighboring gene STARR-positive B cell enhancer ABC_E1444 Neighboring gene STARR-seq mESC enhancer starr_32714 Neighboring gene STARR-seq mESC enhancer starr_32715 Neighboring gene H2A histone family, member Z pseudogene Neighboring gene RNA binding motif protein 25 Neighboring gene STARR-positive B cell enhancer ABC_E7159 Neighboring gene STARR-positive B cell enhancer ABC_E3061 Neighboring gene presenilin 1 Neighboring gene farnesyl diphosphate synthetase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding. Zhong X, et al. Cell Mol Immunol, 2020 Jul. PMID 31388100, Free PMC Article
    2. ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response. Zhong X, et al. PLoS Pathog, 2020 Apr. PMID 32251420, Free PMC Article
    3. Cellular localization and tissue distribution of endogenous DFCP1 protein. Nanao T, et al. Biomed Res, 2015. PMID 25876663
    4. DFCP1 associates with lipid droplets. Gao G, et al. Cell Biol Int, 2019 Dec. PMID 31293035
    5. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Li D, et al. Cell Rep, 2019 Apr 9. PMID 30970241

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
      Title: The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding.
    2. ZFYVE1 acts as a specific negative regulator of MDA5-mediated innate immune responses by inhibiting its ligand binding and oligomerization.
      Title: ZFYVE1 negatively regulates MDA5- but not RIG-I-mediated innate antiviral response.
    3. Endogenous DFCP1 was preferentially associated with mitochondria rather than with the Golgi apparatus or the endoplasmic reticulum in Hela cells.
      Title: Cellular localization and tissue distribution of endogenous DFCP1 protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid droplet formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation by host of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extrinsic component of omegasome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in omegasome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagophore assembly site ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger FYVE domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359166.1 → NP_001346095.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA222714, AA422700, AC055772, AK139825, BB398888, BC050015, BY147113, BY256667, CF165708, CJ103131, CO043975
      Consensus CDS
      CCDS26028.1
      UniProtKB/Swiss-Prot
      Q3TC20, Q810J8
      UniProtKB/TrEMBL
      Q3UT32
      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 121
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    2. NM_001359167.1 → NP_001346096.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA422700, AC055772, AC139382, AK090334
      Consensus CDS
      CCDS26028.1
      UniProtKB/Swiss-Prot
      Q3TC20, Q810J8
      UniProtKB/TrEMBL
      Q3UT32
      Related
      ENSMUSP00000152501.2, ENSMUST00000221919.2
      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 121
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    3. NM_001359168.1 → NP_001346097.1  zinc finger FYVE domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AA422700, AC139382, AK139825
      Conserved Domains (2) summary
      cd15734
      Location:296 → 356
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:179 → 240
      FYVE_like_SF; FYVE domain like superfamily

    4. NM_001422984.1 → NP_001409913.1  zinc finger FYVE domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC055772, AC139382
      UniProtKB/Swiss-Prot
      Q3TC20, Q810J8

    5. NM_183154.4 → NP_898977.2  zinc finger FYVE domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_898977.2

      Status: VALIDATED

      Source sequence(s)
      AA422700, AC055772, AC139382, BC050015
      Consensus CDS
      CCDS26028.1
      UniProtKB/Swiss-Prot
      Q3TC20, Q810J8
      UniProtKB/TrEMBL
      Q3UT32
      Related
      ENSMUSP00000042224.5, ENSMUST00000048319.6
      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 121
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    RNA

    1. NR_186678.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC055772, AC139382

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      83593330..83679289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157320.1 → XP_036013213.1  zinc finger FYVE domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cd15734
      Location:296 → 356
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:179 → 240
      FYVE_like_SF; FYVE domain like superfamily

    2. XM_006515690.5 → XP_006515753.1  zinc finger FYVE domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006515753.1

      UniProtKB/Swiss-Prot
      Q3TC20, Q810J8
      UniProtKB/TrEMBL
      Q3UT32
      Conserved Domains (5) summary
      cd01851
      Location:174 → 410
      GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
      cd15734
      Location:711 → 771
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:594 → 655
      FYVE_like_SF; FYVE domain like superfamily
      cd19819
      Location:16 → 63
      Bbox1_ZFYVE1_rpt1; first B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins
      cd19820
      Location:69 → 121
      Bbox1_ZFYVE1_rpt2; second B-box-type 1 zinc finger found in zinc finger FYVE domain-containing protein 1 (ZFYVE1) and similar proteins

    3. XM_036157321.1 → XP_036013214.1  zinc finger FYVE domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cd15734
      Location:296 → 356
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:179 → 240
      FYVE_like_SF; FYVE domain like superfamily

    4. XM_030246658.2 → XP_030102518.1  zinc finger FYVE domain-containing protein 1 isoform X2

      Conserved Domains (2) summary
      cd15734
      Location:296 → 356
      FYVE_ZFYV1; FYVE domains found in zinc finger FYVE domain-containing protein 1 (ZFYV1) and similar proteins
      cl28890
      Location:179 → 240
      FYVE_like_SF; FYVE domain like superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810J8.2 GenPept UniProtKB/Swiss-Prot:Q810J8

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