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    Susd6 sushi domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 217684, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Susd6provided by MGI
    Official Full Name
    sushi domain containing 6provided by MGI
    Primary source
    MGI:MGI:2444661
    See related
    Ensembl:ENSMUSG00000021133 AllianceGenome:MGI:2444661
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0247; 4933426M11Rik
    Summary
    Predicted to be involved in cell death and cellular response to DNA damage stimulus. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in genitourinary system; heart; integumental system; lung; and stomach. Orthologous to human SUSD6 (sushi domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 33.0), colon adult (RPKM 26.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Susd6 in Genome Data Viewer
    Location:
    12 C3; 12 37.05 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80837306..80927607)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80790532..80880833)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 Neighboring gene predicted gene, 51986 Neighboring gene STARR-seq mESC enhancer starr_32646 Neighboring gene coiled-coil domain containing 177 Neighboring gene STARR-seq mESC enhancer starr_32647 Neighboring gene STARR-seq mESC enhancer starr_32648 Neighboring gene STARR-seq mESC enhancer starr_32649 Neighboring gene STARR-positive B cell enhancer ABC_E5337 Neighboring gene STARR-seq mESC enhancer starr_32653 Neighboring gene STARR-seq mESC enhancer starr_32654 Neighboring gene RIKEN cDNA 1700052I22 gene Neighboring gene predicted gene, 23298

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]. Polato F, et al. J Natl Cancer Inst, 2014 Apr. PMID 24652652, Free PMC Article
    2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sushi domain-containing protein 6
    Names
    drago

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242419.1 → NP_001229348.1  sushi domain-containing protein 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001229348.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK030233, AK152500, AK161132, BP762731
      Consensus CDS
      CCDS88361.1
      UniProtKB/TrEMBL
      Q6ZQF4, Q8C0M5
      Related
      ENSMUSP00000151831.2, ENSMUST00000220238.2
      Conserved Domains (2) summary
      cd00033
      Location:63 → 119
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam08333
      Location:41 → 55
      DUF1725; Protein of unknown function (DUF1725)

    2. NM_178682.4 → NP_848797.1  sushi domain-containing protein 6 isoform 2 precursor

      See identical proteins and their annotated locations for NP_848797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK152500, AK161132, BP762731
      Consensus CDS
      CCDS26016.1
      UniProtKB/Swiss-Prot
      Q8BGE4
      UniProtKB/TrEMBL
      Q3TP03, Q3U749
      Related
      ENSMUSP00000064961.6, ENSMUST00000068519.7
      Conserved Domains (1) summary
      cd00033
      Location:42 → 98
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80837306..80927607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157311.1 → XP_036013204.1  sushi domain-containing protein 6 isoform X1

      UniProtKB/TrEMBL
      Q6ZQF4, Q8C0M5
      Conserved Domains (2) summary
      cd00033
      Location:63 → 119
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam08333
      Location:41 → 55
      DUF1725; Protein of unknown function (DUF1725)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGE4.1 GenPept UniProtKB/Swiss-Prot:Q8BGE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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