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    Ankmy2 ankyrin repeat and MYND domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 217473, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ankmy2provided by MGI
    Official Full Name
    ankyrin repeat and MYND domain containing 2provided by MGI
    Primary source
    MGI:MGI:2144755
    See related
    Ensembl:ENSMUSG00000036188 AllianceGenome:MGI:2144755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ZMYND20
    Summary
    Enables enzyme binding activity. Predicted to be located in cilium. Is expressed in brain; spinal cord; tail dorsal root ganglion; and trigeminal ganglion. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 13.0), bladder adult (RPKM 11.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A3; 12 16.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (36207123..36247290)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (36157124..36197291)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2F (putative), retrotransposed Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_31915 Neighboring gene STARR-positive B cell enhancer ABC_E1153 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene leucine rich repeat containing 72 Neighboring gene STARR-seq mESC enhancer starr_31916 Neighboring gene predicted gene, 40390 Neighboring gene STARR-seq mESC enhancer starr_31918 Neighboring gene predicted gene, 40392 Neighboring gene STARR-seq mESC enhancer starr_31919

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. Jensen VL, et al. PLoS Genet, 2010 Nov 24. PMID 21124868, Free PMC Article
    2. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling. Somatilaka BN, et al. Dev Cell, 2020 Sep 28. PMID 32702291, Free PMC Article
    3. Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway. Saita S, et al. J Biol Chem, 2014 Sep 12. PMID 25077969, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
      Title: Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.
    2. Our findings thus indicate that the FKBP38-ANKMY2 axis plays a key role in regulation of Shh signaling in vivo
      Title: Role of the ANKMY2-FKBP38 axis in regulation of the Sonic hedgehog (Shh) signaling pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18754

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and MYND domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146033.3 → NP_666145.3  ankyrin repeat and MYND domain-containing protein 2

      See identical proteins and their annotated locations for NP_666145.3

      Status: VALIDATED

      Source sequence(s)
      AK077556, AK164434, BF453918, BY069852
      Consensus CDS
      CCDS25885.1
      UniProtKB/Swiss-Prot
      Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1
      Related
      ENSMUSP00000039484.4, ENSMUST00000041640.5
      Conserved Domains (4) summary
      cd00204
      Location:30 → 132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01753
      Location:320 → 357
      zf-MYND; MYND finger
      pfam13857
      Location:31 → 87
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:45 → 77
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      36207123..36247290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157307.1 → XP_036013200.1  ankyrin repeat and MYND domain-containing protein 2 isoform X1

      Conserved Domains (3) summary
      sd00045
      Location:36 → 68
      ANK; ANK repeat [structural motif]
      pfam01753
      Location:311 → 348
      zf-MYND; MYND finger
      pfam12796
      Location:41 → 123
      Ank_2; Ankyrin repeats (3 copies)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178910.2: Suppressed sequence

      Description
      NM_178910.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TPE9.1 GenPept UniProtKB/Swiss-Prot:Q3TPE9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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