Inmt indolethylamine N-methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Inmtprovided by MGI
Official Full Name: indolethylamine N-methyltransferaseprovided by MGI
Primary source: MGI:MGI:102963
See related: Ensembl:ENSMUSG00000003477 AllianceGenome:MGI:102963
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Temt
Summary: Enables thioether S-methyltransferase activity. Predicted to be involved in amine metabolic process and methylation. Predicted to act upstream of or within response to toxic substance. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; eye; heart; and skeleton. Orthologous to human INMT (indolethylamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in lung adult (RPKM 556.8), liver adult (RPKM 128.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.38 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (55147612..55151975, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (55170627..55174990, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We found that indole-N-methyl transferase is localized to postsynaptic sites of C-terminals in close proximity to the S1R
Title: Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N'-dimethyltryptamine forming enzyme, indole-N-methyl transferase.
IDO may suppress overactive immune response in the alpha-GalCer-induced hepatitis model.
Title: Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables amine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amine N-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables dimethyl selenide methyltransferase activity	TAS Traceable Author Statement more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables thioether S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioether S-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: indolethylamine N-methyltransferase

Names: amine N-methyltransferase; aromatic alkylamine N-methyltransferase; arylamine N-methyltransferase; indolamine N-methyltransferase; nicotine N-methyltransferase; thioether S-methyltransferase

NP_033375.1

EC 2.1.1.49

EC 2.1.1.96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.