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    Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 [ Mus musculus (house mouse) ]

    Gene ID: 217378, updated on 12-May-2024

    Summary

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    Official Symbol
    Dnajc27provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C27provided by MGI
    Primary source
    MGI:MGI:2443036
    See related
    Ensembl:ENSMUSG00000020657 AllianceGenome:MGI:2443036
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rbj; Rabj; C330021A05Rik
    Summary
    Enables GTPase activity. Involved in positive regulation of ERK1 and ERK2 cascade and regulation of MAPK export from nucleus. Located in nucleus. Orthologous to human DNAJC27 (DnaJ heat shock protein family (Hsp40) member C27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis adult (RPKM 12.8), cerebellum adult (RPKM 9.3) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 A1.1; 12 1.99 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (4132569..4174140)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (4082569..4124140)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene Pomc promoter region Neighboring gene STARR-positive B cell enhancer mm9_chr12:3959806-3960107 Neighboring gene STARR-positive B cell enhancer mm9_chr12:3981365-3981666 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:3982390-3982573 Neighboring gene pro-opiomelanocortin-alpha Neighboring gene EFR3 homolog B Neighboring gene STARR-seq mESC enhancer starr_31433 Neighboring gene STARR-positive B cell enhancer mm9_chr12:4082834-4083134 Neighboring gene adenylate cyclase 3 Neighboring gene predicted gene, 53749 Neighboring gene STARR-seq mESC enhancer starr_31436 Neighboring gene centromere protein O Neighboring gene ubiquitin associated protein 2-like pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression. Chen T, et al. Cancer Cell, 2014 May 12. PMID 24746703
    2. RJLs: a new family of Ras-related GTP-binding proteins. Nepomuceno-Silva JL, et al. Gene, 2004 Mar 3. PMID 14980719
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 27
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 27
    Rab-related GTP-binding protein
    rab and DnaJ domain containing
    rab and DnaJ domain-containing protein
    NP_694722.2
    XP_006515115.1
    XP_006515116.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153082.4 → NP_694722.2  dnaJ homolog subfamily C member 27

      See identical proteins and their annotated locations for NP_694722.2

      Status: VALIDATED

      Source sequence(s)
      CB247441, CT572999
      Consensus CDS
      CCDS25786.1
      UniProtKB/Swiss-Prot
      Q8BX00, Q8CFP6, Q923I0
      Related
      ENSMUSP00000020986.8, ENSMUST00000020986.15
      Conserved Domains (2) summary
      cd06257
      Location:217 → 264
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      cd04119
      Location:17 → 184
      RJL; Rab GTPase family J-like (RabJ-like)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      4132569..4174140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515053.5 → XP_006515116.1  dnaJ homolog subfamily C member 27 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:17 → 99
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_006515052.3 → XP_006515115.1  dnaJ homolog subfamily C member 27 isoform X1

      Conserved Domains (2) summary
      cd06257
      Location:242 → 289
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      cd04119
      Location:17 → 209
      RJL; Rab GTPase family J-like (RabJ-like)

    RNA

    1. XR_004937483.1 RNA Sequence

    2. XR_004937484.1 RNA Sequence

    3. XR_872399.3 RNA Sequence

    4. XR_381181.3 RNA Sequence

    5. XR_381182.3 RNA Sequence

    6. XR_381183.4 RNA Sequence

    7. XR_381184.3 RNA Sequence

    8. XR_003950028.2 RNA Sequence

    9. XR_003950031.2 RNA Sequence

    10. XR_003950029.2 RNA Sequence

    11. XR_003950030.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFP6.1 GenPept UniProtKB/Swiss-Prot:Q8CFP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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