U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Rnf157 ring finger protein 157 [ Mus musculus (house mouse) ]

    Gene ID: 217340, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rnf157provided by MGI
    Official Full Name
    ring finger protein 157provided by MGI
    Primary source
    MGI:MGI:2442484
    See related
    Ensembl:ENSMUSG00000052949 AllianceGenome:MGI:2442484
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1917; 2610036E23Rik; A130073L17Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of signal transduction; positive regulation of dendrite extension; and protein autoubiquitination. Predicted to be located in cell body. Predicted to be active in early endosome; nucleus; and plasma membrane. Is expressed in future spinal cord. Orthologous to human RNF157 (ring finger protein 157). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 39.1), cortex adult (RPKM 38.6) and 14 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    11 E2; 11 81.17 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116227179..116303859, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116336345..116413391, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26730 Neighboring gene STARR-seq mESC enhancer starr_31197 Neighboring gene STARR-seq mESC enhancer starr_31198 Neighboring gene forkhead box J1 Neighboring gene STARR-positive B cell enhancer ABC_E5299 Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:116255636-116255937 Neighboring gene STARR-positive B cell enhancer ABC_E9382 Neighboring gene STARR-positive B cell enhancer ABC_E8472 Neighboring gene STARR-positive B cell enhancer ABC_E5300 Neighboring gene STARR-positive B cell enhancer ABC_E10733 Neighboring gene STARR-seq mESC enhancer starr_31202 Neighboring gene STARR-seq mESC enhancer starr_31205 Neighboring gene UBA-like domain containing 2 Neighboring gene glutamine rich 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development. Kong JH, et al. Dev Cell, 2020 Nov 23. PMID 32966817, Free PMC Article
    2. Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157. Matz A, et al. Cell Death Differ, 2015 Apr. PMID 25342469, Free PMC Article
    3. Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord. Masuda T, et al. Brain Res, 2009 Jan 16. PMID 19026994
    4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF157 attenuates CD4[+] T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
      Title: RNF157 attenuates CD4(+) T cell-mediated autoimmune response by promoting HDAC1 ubiquitination and degradation.
    2. RNF157 has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical.
      Title: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (2)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin ligase Rnf157
    Names
    RING-type E3 ubiquitin transferase Rnf157
    NP_001392066.1
    NP_001392067.1
    NP_001392068.1
    NP_001392069.1
    NP_001392070.1
    NP_001392071.1
    NP_001392072.1
    NP_001392073.1
    NP_001392074.1
    NP_081534.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405137.1 → NP_001392066.1  E3 ubiquitin ligase Rnf157 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645861

    2. NM_001405138.1 → NP_001392067.1  E3 ubiquitin ligase Rnf157 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL645861

    3. NM_001405139.1 → NP_001392068.1  E3 ubiquitin ligase Rnf157 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL645861

    4. NM_001405140.1 → NP_001392069.1  E3 ubiquitin ligase Rnf157 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL645861

    5. NM_001405141.1 → NP_001392070.1  E3 ubiquitin ligase Rnf157 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL645861

    6. NM_001405142.1 → NP_001392071.1  E3 ubiquitin ligase Rnf157 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL645861

    7. NM_001405143.1 → NP_001392072.1  E3 ubiquitin ligase Rnf157 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL645861

    8. NM_001405144.1 → NP_001392073.1  E3 ubiquitin ligase Rnf157 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL645861

    9. NM_001405145.1 → NP_001392074.1  E3 ubiquitin ligase Rnf157 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL645861

    10. NM_027258.2 → NP_081534.1  E3 ubiquitin ligase Rnf157 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL645861
      Consensus CDS
      CCDS48984.1
      UniProtKB/TrEMBL
      A2AAN9, A2AAP0
      Related
      ENSMUSP00000097776.4, ENSMUST00000100202.10
      Conserved Domains (1) summary
      pfam13920
      Location:276 → 318
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116227179..116303859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TEL6.2 GenPept UniProtKB/Swiss-Prot:Q3TEL6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous